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The aim of the project has been to elucidate molecular events leading to amyloidosis in Hereditary Cystatin C Amyloid Angiopathy (HCCAA) patients, to enable simple diagnosis of the disease and with the ultimate goal to understand the amyloid formation process in detail, in order to develop inhibitors to the process. At the DNA level, a point mutation segregating with HCCAA was identified in the cy
Context. On the order of 20% of the very metal-poor stars in the Galaxy exhibit large carbon enhancements. It is important to establish which astrophysical sites and processes are responsible for the elemental abundance patterns of this early Galactic population. Aims. We seek to understand the nature of the progenitors of three main-sequence turnoff Carbon-Enhanced Metal-Poor (CEMP) stars, CS 310
BACKGROUND: Triticum aestivum (wheat) is one of the world's oldest crops and has been used for >8000 years as a food crop in North Africa, West Asia and Europe. Today, wheat is one of the most important sources of grain for humans, and is cultivated on greater areas of land than any other crop. As the human population increases and soil salinity becomes more prevalent, there is increased pressure
This presentation discusses an ongoing research project that aims to collect data about the practice of information search. It seeks to learn more about different ways in which tourist information is collected at different stages of a journey. Speaking to tourism planners and reading tourism research, it seems as if the digitalization of information has completely changed tourists’ information sea
Aims/hypothesis: P-element induced Wimpy testis (PIWI)-interacting RNAs (piRNAs) are small non-coding RNAs that interact with PIWI proteins and guide them to silence transposable elements. They are abundantly expressed in germline cells and play key roles in spermatogenesis. There is mounting evidence that piRNAs are also present in somatic cells, where they may accomplish additional regulatory ta
Aims and objectives: To describe ways in which children's best interests were observed to be expressed in paediatric settings during their hospital visit.Background: The best interests of the child are embodied in national and international legal systems, although the definition remains problematic. The child's limited autonomy mandates duty bearers to have both a child perspective and the child's
Numbers are used for exact and approximative estimations. The numbers used in approximative expressions are typically so-called round numbers, such as 10, 20, 25, 30, 40, 50, 100, 1,000, and such numbers are also very frequent in texts. This article presents evidence that some numbers are rounder than others and discusses how the roundness of a number can be derived from its contents of the base n
In the summer of 2013, millions of Egyptians returned to Tahrir square in Cairo to demand the resignation of the country’s first democratically elected president. This article examines the two key terms mainly used to describe the ousting of President Mohamed Morsy, ‘coup’ and ‘revolution’, and how these terms can be understood as arguments for two different interpretations of the event. Particula
Promoting or upscaling governance and business innovations requires an understanding about the conditions and contexts that support a particular innovation. Indeed, context can importantly condition the emergence of new ideas as well as their stabilization and system-level uptake. Ecosystems and the services they provide can be considered this kind of context for innovations because they vary acro
Solid materials doped with rare-earth ions are considered an attractive platform for quantum information applications. One of the main reasons for this is the exceptionally long optical and hyperfine coherence times of the 4fn states, due to the shielding provided by the outer lying 5s and 5p electrons. This enables a large number of quantum operations before the system loses its coherence. Anothe
This article examines the interpretation of biosignatures, the signs of life that could bedetected in outer space. In astrobiology biosignatures could be of various kinds, fossils, molecules, traces, artefacts, structures, electromagnetic waves, etc. The purpose of this article is to bring some semiotic order in this seemingly chaotic variation of signs. It turns out that the semiotic function of
In agro-ecosystems, environmental monitoring is fundamental to detect and survey changes related to land use change and management practices. Butterflies and moths have often been suggested as suitable indicators for monitoring environmental effects on biodiversity in farmlands. Here, we estimated the required sample size and monitoring effort necessary to run a Lepidoptera survey in European farm
In 1988 Hills proposed that stars can gain velocities above 500 km s−1 if they are in a stellar binary which gets disrupted by a super massive black hole (SMBH). One of the stars would get trapped in an elliptical orbit around the SMBH while the other gets ejected and obtains a relatively high velocity. Normally stars within galaxies have low peculiar velocities but stars ejected with velocities o
Travel on railway in Sweden has increased steadily over the past three decades and there are today twice as many passengers travelling by train as there were 30 years ago. The increasing awareness of environmental issues with other methods of transportation is likely to favour railway travel, and so the number of passengers is expected to continue to rise. As the number of passengers increase, so
Uppsatsens syfte är att fördjupa insikten i hur verksamheter som traditionellt inte ses som kunskapsintensiv hanterar tvetydighet. För att nå syftet med uppsatsen har en kvalitativ studie genomförts. Uppsatsen har en utgångpunkt från en tolkande kunskapssyn på studieobjekten och har en induktiv ansats. Den teoretiska referensramen består inledningsvis av kunskapsintensiva verksamheters karaktärist
17 kap. 3§ andra meningen rättegångsbalken (RB) anses innefatta en så kallad åberopsbörda. Beroende på ett rättsfaktums art står en viss part risken för att en omständighet inte åberopats, med följden att omständigheten faller utanför domstolens prövningsram. Rättsfakta kan beskrivas som sakomständigheter vilka påstås uppfylla rekvisit i en materiell rättsregel. Käranden anses som utgångspunkt behChapter 17, section 3, second sentence of the Swedish Code of Judicial Pro-cedure (SCJP) is considered to include a so-called burden of pleading. Depending on the nature of a material fact, if not pleaded, one of the parties stands the risk of that fact falling outside the scope of the court’s review. Material facts can be described as material circumstances which are claimed to fulfil the prerequ
