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Immunoglobulin G (IgG) is the main isotype of antibody in human blood. IgG consists of four subclasses (IgG1 to IgG4), encoded by separate constant region genes within the Ig heavy chain locus (IGH). Here, we report a genome-wide association study on blood IgG subclass levels. Across 4334 adults and 4571 individuals under 18 years, we discover ten new and identify four known variants at five loci
Background: Platelet transfusions are given to preterm infants with severe thrombocytopenia aiming to prevent haemorrhage. The PlaNeT2/MATISSE trial revealed higher rates of mortality and/or major bleeding in preterm infants receiving prophylactic platelet transfusions at a platelet count threshold of 50 × 109/L compared to 25 × 109/L. The extent to which this evidence has been incorporated into c
This paper presents the results of the 2022 Groundwater Time Series Modelling Challenge, where 15 teams from different institutes applied various data-driven models to simulate hydraulic-head time series at four monitoring wells. Three of the wells were located in Europe and one was located in the USA in different hydrogeological settings in temperate, continental, or subarctic climates. Participa
In clinical practice, the glomerular filtration rate (GFR), a measurement of kidney functioning, is normally calculated using equations, such as the European Kidney Function Consortium (EKFC) equation. Despite being the most general equation, EKFC, just like previously proposed approaches, can still struggle to achieve satisfactory performance, limiting its clinical applicability. As a possible so
BACKGROUND: Lymphatic disorders such as protein-losing enteropathy, plastic bronchitis, and chylothorax are important complications of the Fontan circulation and ultimately result in an increased risk of early death. Several European centers are now performing lymphatic procedures. The aim of this study is to map the extent of these lymphatic disorders and treatments provided across European pedia
Importance: Despite increased use of antibiotic-loaded bone cement (ALBC) in joint arthroplasty over recent decades, current evidence for prophylactic use of ALBC to reduce risk of periprosthetic joint infection (PJI) is insufficient. Objective: To compare the rate of revision attributed to PJI following primary total knee arthroplasty (TKA) using ALBC vs plain bone cement. Design, Setting, and Pa
Objectives: The objective of this study is to develop classification criteria for overall hand osteoarthritis (OA), interphalangeal OA and thumb base OA based on self-reported data and radiographic features. Methods: The classification criteria sets were developed in three phases. In phase 1, we identified criteria that discriminated hand OA from controls. In phase 2, we used a consensus-based dec
The increasing threat of soil degradation presents significant challenges to soil health, especially within agroecosystems that are vital for food security, climate regulation, and economic stability. This growing concern arises from intricate interactions between land use practices and climatic conditions, which, if not addressed, could jeopardize sustainable development and environmental resilie
Although biologics have revolutionized psoriasis treatment, they pose a significant burden on the healthcare budget. With the wide range of biologics available and the increasing number of biosimilars, insights into the real-world cost per responder (CPR) are required. Therefore, this study aims to evaluate the real-world CPR of adalimumab, ustekinumab, IL17-and IL23-inhibitors, incorporating both
Background: – The use of antibiotic-loaded bone cement (ALBC) in primary total knee arthroplasty (TKA) is debated. Some argue that ALBC might only be justified in high-risk patients. This study assessed the effectiveness of ALBC vs. plain bone cement (PBC) in reducing risk of revision for periprosthetic joint infection (PJI) in TKA patients considered to have a high risk of infection.Methods: – Co
Sveriges totalförsvar står inför ett behov av snabb återuppbyggnad. Det försämrade säkerhetspolitiska läget i Europa, i kombination med ökade och mer komplexa risker för störningar i samhällskritiska funktioner, har gjort detta arbete allt viktigare. Behovet av att säkra tillgången på varor och tjänster som är avgörande för befolkningens överlevnad och samhällets funktionalitet vid kriser och krig
Popular Abstract in Swedish Yttre faktorerna i omgivningen som UV-strålning från solen, rökning, läkemedel, maten och påfrestande livssituationer kan leda till att kroppens celler börjar överproducera molekyler som kallas syrefria radikaler. Dessa molekyler reagerar kemist mycket lätt med omgivande ämnen. När syrefria radikaler bildas i kroppen i normala mängder ingår de som en del av immunförsvarOxidative stress can cause damage to DNA, proteins and lipids and is associated with inflammation and various human diseases as cancer, atherosclerosis, and autoimmune diseases. Polyphenol-rich diet, such as fruits and berries, may act as antioxidants and prevent oxidative stress and, thereby, associated diseases. Administration of lactic acid bacteria (LAB) can affect the microflora in the gastro
Popular Abstract in Swedish Istiden har påverkat utbredning och variation hos många växter i Europa, framförallt arter i tempererade områden (dvs. norra Europa). Under den sista istiden (som slutade för mindre än 15 000 år sedan) täcktes stora delar av norra Europa, bl.a. hela Skandinavien och norra England, av ismassor. Bergskedjor som finns i södra Europa, t.ex. Karpaterna, Pyrenéerna och AlpernThe Helianthemum oelandicum complex shows considerable morphological variation across its geographic distribution in Europe and western Asia. By combining four primer pairs and four restriction enzymes I identified nine cpDNA haplotypes with distinct geographical distributions. Two haplotypes were most frequent over most of the range; one in western Europe and one in eastern Europe. Moreover, diff
AIM: Subclasses of different glycaemic disturbances could explain the variation in characteristics of individuals with type 2 diabetes (T2D). We aimed to examine the association between subgroups based on their glucose curves during a five-point mixed-meal tolerance test (MMT) and metabolic traits at baseline and glycaemic deterioration in individuals with T2D. METHODS: The study included 787 indi
The neutron-deficient 115Cs was produced at ISOLDE, CERN by spallation reaction using 1.4 GeV proton on LaC2 target. The exotic decay modes were studied by using a charged particle array (DSSD and pad detectors) and a γ-detector array (four Clovers) at the ISOLDE decay station (IDS). In this report, results on observed β-delayed particle emission from 115Cs, a nucleus close to proton drip line, is
Objective: To define the role of ultrasound (US) for the assessment of patients with rheumatoid arthritis (RA) in clinical remission, including joint and tendon evaluation. Methods: A multicentre longitudinal study has been promoted by the US Study Group of the Italian Society for Rheumatology. 25 Italian centres participated, enrolling consecutive patients with RA in clinical remission. All patie
The European Spallation Source is designed to deliver 5 MW proton beam power on the target while keeping the beam induced losses below 1 W/m throughout the LINAC. This implies the need of accurate models to correctly describethe longitudinal beam dynamics within the multi-cell cavities. In all the previous error studies the cells of a multicell cavity were modelled as a sequence of independent gap
Polyploidization is an important process in the evolution of eukaryotic genomes, but ensuing molecular mechanisms remain to be clarified. Autopolyploidization or whole-genome duplication events frequently are resolved in resulting lineages by the loss of single genes from most duplicated pairs, causing transient gene dosage imbalance and accelerating speciation through meiotic infertility. Allopol
