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Chronic pelvic pain (CPP) is chronic or persistent pain perceived in structures related to the pelvis of men and women. Patients with CPP may have pain refractory to conventional management strategies. Botulinum toxin A (BTX-A) injection is a potential therapeutic option in patients with CPP. Beneficial effects of BTX-A on pain, quality of life, and functional symptoms were seen in patients with c

This thesis investigates how suicide is portrayed in japanese films and if it is glorified or not. Two films have been chosen for analysis, Seppuku (Harakiri, Masaki Kobayashi, 1962) and Jisatsu saakuru (Suicide Club/Circle, Shion Sono, 2001). The purpose of the thesis is to find out if suicide is glorified in these two films and to examine the historical and reality connections of the timeperiods

Den svenska sjukvården står inför en utmanande framtid. De dystra prognoserna om en åldrande befolkning och en mindre skattebas får orosmolnen att samla sig. Kostnaden för vården var 229,5 miljarder kronor under 2007 vilket motsvarar ca 9.2 % av BNP. Dessa utgifter förutspås öka. Detta visar sig bland annat i Region Skånes grunddokument för förnyelsearbete där det konstateras att ”Kostnaden per in

The latest Gaia data release enables us to accurately identify stars that are more luminous than would be expected on the basis of their spectral type and distance. During an investigation of the 329 best solar twin candidates uncovered among the spectra acquired by the GALAH survey, we identified 64 such overluminous stars. In order to investigate their exact composition, we developed a data-driv

AIMS: Neutrophils have both detrimental and beneficial effects in myocardial infarction (MI), but little is known about the underlying pathways. S100A8/A9 is a pro-inflammatory alarmin abundantly expressed in neutrophils that is rapidly released in the myocardium and circulation after myocardial ischaemia. We investigated the role of S100A8/A9 in the innate immune response to MI. METHODS AND RESUL

Background: In the phase 3 TITAN study, the addition of apalutamide to androgen deprivation therapy (ADT) significantly improved the primary endpoints of overall survival and radiographic progression-free survival in patients with metastatic castration-sensitive prostate cancer. We aimed to assess health-related quality of life (HRQOL) in TITAN, including pain and fatigue. Methods: In this randomi

Objective: To describe the clinical and ultrasound characteristics of serous cystadenofibromas in the adnexa. Methods: This was a retrospective study of patients identified in the International Ovarian Tumor Analysis (IOTA) database, who had a histological diagnosis of serous cystadenofibroma and had undergone preoperative ultrasound examination by an experienced ultrasound examiner, between 1999

Background: Genetic disorders causing dystonia show great heterogeneity. Recent studies have suggested that next-generation sequencing techniques such as gene panel analysis can be effective in diagnosing heterogeneous conditions. The objective of this study was to investigate whether dystonia patients with a suspected genetic cause could benefit from the use of gene panel analysis. Methods: In th

The N-methyl-d-aspartate receptor (NMDAR) coagonists glycine, d-serine and l-proline play crucial roles in NMDAR-dependent neurotransmission and are associated with a range of neuropsychiatric disorders. We conducted the first genome-wide association study of concentrations of these coagonists and their enantiomers in plasma and cerebrospinal fluid (CSF) of human subjects from the general populati

Popular Abstract in Swedish Cancer är ett laddat ord, och för de flesta av oss är cancern inte längre bort än hos en nära släkting eller vän. Trots den gemensamma benämningen, är cancer är inte bara en sjukdom, utan ca 200 olika som alla har gemensamt att cellerna börjar dela sig okontrollerat. Cancer är väldigt vanligt och uppskattningsvis kommer var tredje person att drabbas av cancer under sin Early diagnosis and reliable prognosis and treatment prediction of breast cancer will ultimately lead to a decreased mortality rate. This can be achieved by identification of prognostic and treatment predictive biomarkers, and by understanding the mechanisms behind early changes in the breast. The cell cycle is a closely controlled process, involving multiple components with regulation on several

Popular Abstract in Swedish Skador på skelettet kan uppstå efter bl.a. olyckor, tumörkirurgi eller strålning. Ofta är sådana skador mycket handikappande då de påverkar kroppens funktion, stabilitet och utseende. Om benvävnad saknas eller måste bytas ut använder man sig idag av mikrokirurgiska metoder, där man flyttar kroppseget ben från ett ställe till ett annat. Tyvärr innebär detta att man skapaBone deficiencies, caused by malformations, trauma or adverse effects from medical treatments, are a clinical challenge and often associated with reduced physical function and quality of life. Autologeous bone grafts can be used to reconstruct skeletal defects, but the right size and quality of bone might not always be available and even so, donor-site morbidity might follow. A pre-fabricated or t

Background: Novel peritoneal dialysis solutions are characterized by a minimal content of glucose degradation products and a neutral pH. Many studies have shown the biocompatibility of neutral lactate-buffered solutions; however, until now, the effect of purely bicarbonate-buffered solutions has not been intensively studied in vivo. Methods: This study was an open label, prospective, crossover mul

Background: Colon capsule endoscopy (CCE) represents a noninvasive technology that allows visualization of the colon without requiring sedation and air insufflation. A second-generation colon capsule endoscopy system (PillCam Colon 2) (CCE-2) was developed to increase sensitivity for colorectal polyp detection compared with the first-generation system. Objective: To assess the feasibility, accurac

Internet har bara de senaste årtiondena intagit en självklar roll i västvärldens vardag; genom denna kanal sker såväl social kommunikation och marknadsföring som affärstransaktioner och myndighetsutövning. Internets framväxt – och dess stigande antal användare – har givit upphov till nya behov av lagstiftning och normering; när den nya tekniken, vilken utvecklas och breddas för var dag som går, möFor the last decades, the Internet has become a natural factor in the every day life of citizens of the West; through this channel of communication, social media and advertising, as well as business transactions and exercising of authority is carried out on a daily basis. The development of the Internet – and its many users – have given rise to new needs for legislation and standards; when technol

En högriskobligation, eller företagsobligation med hög risk, är ett sätt för ett litet- eller medelstort företag med låg kreditvärdighet att anskaffa pengar på kapitalmarknaden. I takt med att hårdare krav ställs på seniora långivare så växer betydelsen av en välutvecklad marknad för högriskobligationer i Sverige. Detta är nödvändigt för att bibehålla en global konkurrenskraft hos svenska små- ochA high-yield bond is a financing option for a non-investment grade corporation, enabling it to raise funds on the capital market. In light of harsher conditions for senior financing, the development of a liquid high-yield market for bonds may prove a necessary way forward to ensure global competitiveness for Swedish small and medium-sized enterprises (“SMEs”) that typically relies heavily on bilat

Till följd av den digitala ekonomins framfart de senaste decennierna står det internationella skattesystemet inför flertalet stora utmaningar. De gällande principerna inom den internationella skatterätten har ställts på sin spets då nutidens företag i allt större utsträckning är digitala. Enligt principer inom den internationella skatterätten måste ett företag i dagsläget ha en grad av fysisk närvDue to the progress of the digital economy over the last decades, the international tax system is now facing several substantial challenges. The current principles within international taxation law have consequently been pushed to their edge as a result of the digitalization of present-day companies. According to current principles within international tax law, enterprises must have a degree of ph

Att E-handeln ökat stort de senaste åren har inte gått ouppmärksammat och dess inslag har märkts både privat och inom näringslivet. Den fysiska handeln har ändrats handel via internet vilket är en utveckling från byteshandel som var en av de tidigaste handelsformerna. Sedan internet, och E-handelns, lansering i början av 1990-talet har utvecklingen gått snabbt och de senaste tjugo åren har omsättnThe fact that e-commerce has increased significantly in recent years has not gone unnoticed, and its features have been marked in both private life as well as in business. The physical commerce has changed to an increased shopping through the internet, which is a development of the trade of goods that was one of the earliest commercial forms. Since the internet, and thereby the E-commerce, was lau

Grass (Poaceae) pollen is the most important outdoor aeroallergen,1 exacerbating a range of respiratory conditions, including allergic asthma and rhinitis ("hay fever").2-5 Understanding the relationships between respiratory diseases and airborne grass pollen with a view to improving forecasting has broad public health and socioeconomic relevance. It is estimated that there are over 400 million pe

We have identified a first group of 33 new candidates for symbiotic stars (SySt) of the accreting-only variety among the 600 255 stars so far observed by the GALactic Archaeology with HERMES (GALAH) high-resolution spectroscopic survey of the Southern hemisphere, more than doubling the number of those previously known. GALAH aims to high latitudes and this offers the possibility to sound the Galax