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Science Journals — AAAS REVIEW SUMMARY ◥ OXYGEN SENSING Oxygen-sensing mechanisms across eukaryotic kingdoms and their roles in complex multicellularity Emma U. Hammarlund*†, Emily Flashman, Sofie Mohlin, Francesco Licausi*† BACKGROUND:Animals and land plants are the most diverse complex multicellular life-forms on Earth, and their success intricately links a capacity for adhering cells to perform

https://www.tcr.lu.se/sites/tcr.lu.se/files/2020-11-16_hammarlund_et_al_2020.pdf - 2026-07-22

Objectives To describe clinical history and ultrasound findings in patients with tubal carcinoma. Methods Patients with a histological diagnosis of tubal cancer who had undergone preoperative ultrasound examination were identified from the databases of 13 ultrasound centers. The tumors were described by the principal investigator at each contributing center on the basis of ultrasound images, ultra

Objectives To perform fine mapping of the autoimmunity susceptibility gene BLK and identify functional variants involved in systemic lupus erythematosus (SLE). Methods Genotyping of 1163 European SLE patients and 1482 controls and imputation were performed covering the BLK gene with 158 single-nucleotide polymorphisms. Logistic regression analysis was done using PLINK and conditional analyses usin

Here for the first time, we detail self-contained (wireless and self-powered) biodevices with wireless signal transmission. Specifically, we demonstrate the operation of self-sustained carbohydrate and oxygen sensitive biodevices, consisting of a wireless electronic unit, radio transmitter and separate sensing bioelectrodes, supplied with electrical energy from a combined multi-enzyme fuel cell ge

Previously, a healthy Nordic diet (ND) has been shown to have beneficial health effects close to those of Mediterranean diets.

To analyse the differences between patients with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) entered into randomised clinical trials (RCTs) and those followed in large observational cohorts.

We report here on the discovery of laser action in the range 0.9-2 μm in several spectral lines of Fe II, which are associated with transitions from "pseudo-metastable" states populated by spontaneous transitions from Lyα pumped Fe II levels. The intense Lyα radiation is formed in the HII region of gas condensations close to the star η Car. The laser transitions form together with spontaneous tran

Calcium phosphate materials (CaPs) have proven biocompatible and useful in clinical situations. One CaP showing promise in the clinic is alpha phase tricalcium phosphate ([alpha]-TCP). [alpha]-TCP in powder form can be hydrated and undergoes a reaction resulting in calcium deficient hydroxyapatite (CDHA). The similarity of CDHA and human bone makes [alpha]-TCP a very viable material for applicatio

This thesis investigates how suicide is portrayed in japanese films and if it is glorified or not. Two films have been chosen for analysis, Seppuku (Harakiri, Masaki Kobayashi, 1962) and Jisatsu saakuru (Suicide Club/Circle, Shion Sono, 2001). The purpose of the thesis is to find out if suicide is glorified in these two films and to examine the historical and reality connections of the timeperiods

We have identified a first group of 33 new candidates for symbiotic stars (SySt) of the accreting-only variety among the 600 255 stars so far observed by the GALactic Archaeology with HERMES (GALAH) high-resolution spectroscopic survey of the Southern hemisphere, more than doubling the number of those previously known. GALAH aims to high latitudes and this offers the possibility to sound the Galax

PURPOSE: We performed an exploratory analysis of prostate cancer-related pain and fatigue on health-related quality of life in patients with metastatic castration-sensitive prostate cancer receiving apalutamide (240 mg/day) or placebo, with continuous androgen deprivation therapy (ADT), in the phase 3, randomized, double-blind, placebo controlled TITAN trial (NCT02489318). MATERIALS AND METHODS: P

In the last ten years, x-ray free-electron lasers (XFELs) have been successfully employed to characterize metalloproteins at room temperature using various techniques including x-ray diffraction, scattering, and spectroscopy. The approach has been to outrun the radiation damage by using femtosecond (fs) x-ray pulses. An example of an important and damage sensitive active metal center is the Mn4CaO

Health system resilience, known as the ability for health systems to absorb, adapt or transform to maintain essential functions when stressed or shocked, has quickly gained popularity following shocks like COVID-19. The concept is relatively new in health policy and systems research and the existing research remains mostly theoretical. Research to date has viewed resilience as an outcome that can

BACKGROUND: 4-hydroxychlorothalonil (HCT, R182281), a transformation product of the fungicide chlorothalonil, was recently identified in human serum and breast milk. There are indications that HCT may be more toxic and environmentally persistent than chlorothalonil.OBJECTIVE: Our aim was to investigate serum concentrations of HCT in pregnant women in Sweden and Costa Rica.METHODS: We developed a q

In mitosis, most transcription factors detach from chromatin, but some are retained and bookmark genomic sites. Mitotic bookmarking has been implicated in lineage inheritance, pluripotency and reprogramming. However, the biological significance of this mechanism in vivo remains unclear. Here, we address mitotic retention of the hemogenic factors GATA2, GFI1B and FOS during haematopoietic specifica

Although sex and gender are recognized as major determinants of health and immunity, their role is rarely considered in clinical practice and public health. We identified six bottlenecks preventing the inclusion of sex and gender considerations from basic science to clinical practice, precision medicine and public health policies. (i) A terminology-related bottleneck, linked to the definitions of

Manganese (Mn), an essential nutrient, is a neurotoxicant at high concentrations. We measured Mn concentrations in repeated blood and hair samples collected from 449 pregnant women living near banana plantations with extensive aerial spraying of Mn-containing fungicide mancozeb in Costa Rica, and examined environmental and lifestyle factors associated with these biomarkers. Mean blood Mn and geome