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C4b-binding protein (C4BP) is a well-known regulator of the complement system that holds additional and important activities unrelated to complement inhibition. Recently, we have described a novel immunomodulatory activity in the minor C4BP(β-) isoform directly acting over inflammatory phagocytes. Here we show that incorporation of the β-chain to the C4BP α-chain oligomer interferes with this immu
Surface guidance systems enable patient positioning and motion monitoring without using ionising radiation. Surface Guided Radiation Therapy (SGRT) has therefore been widely adopted in radiation therapy in recent years, but guidelines on workflows and specific quality assurance (QA) are lacking. This ESTRO-ACROP guideline aims to give recommendations concerning SGRT roles and responsibilities and
Pulmonary arterial hypertension (PAH) is a condition that leads to lethal right heart failure. Available treatments provide relief but are far from curative and the vascular remodeling in PAH has been difficult to decipher. Although pathognomonic to PAH, the plexiform lesions are difficult to define, and there is no consensus regarding their potential hemodynamic impact. Versican is an extracellul
Urbana översvämningar orsakar stora samhällsskador och skyfallens snabba och lokala karaktär gör dem svåra att observera, förutsäga och varna för. Det finns också brist på data om översvämningsskador, främst på grund av knapp och icke-systematisk datainsamling och -hantering. I denna artikel presenterar vi ett nytt forskningsprojekt: SPARC. Det övergripande syftet med projektet är att förbättra säUrban flooding causes large societal damages and increased climate adaptation measures is needed. Therapid and local character of extreme rain events make them difficult to observe and predict, and to issuewarnings for. There is also a lack of data on urban flood damages, mainly because of scarce and nonsystematic data collection and management. In this paper, we present the approaches behind the
Coastal aeolian sediment transport is influenced by supply-limiting factors caused by sediment sorting by grain size. Sorting processes can lead to coarsening of the bed surface and influence the formation of aeolian ripples. However, the influence sorting processes and bedforms might have on the magnitude of the transport is not fully understood. This study explores sorting processes and their in
The distortion of a sound wave during propagation results in progressive transfer of the energy from fundamental to higher harmonics, and is dependent on the nonlinearity of the medium. We studied if relative changes in acoustical nonlinearity occur in healthy myocardium during the cardiac cycle. Radiofrequency data were acquired from transthoracic echocardiography (2.5 and 3.5 MHz), parasternal l
Background: With advances in clinical genetic testing, associations between genetic neurodevelopmental disorders and parkinsonism are increasingly recognized. In this review, we aimed to provide a comprehensive overview of reports on parkinsonism in genetic neurodevelopmental disorders and summarize findings related to genetic diagnosis, clinical features and proposed disease mechanisms. Methods:
Background: The use of disease-modifying therapies (DMTs) in multiple sclerosis (MS) has been associated with reduced relapse rates and accumulation of disability. However, studies examining impact of DMT on risk of transition to secondary progressive MS (SPMS) leveraging population-based nationwide data are still rare. Here, we determine the population incidence of conversion to SPMS using two co
Dystonia is a movement disorder in which patients have involuntary abnormal movements or postures. Non-motor symptoms, such as psychiatric symptoms, sleep problems and fatigue, are common. We hypothesise that the gut microbiome might play a role in the pathophysiology of the (non-)motor symptoms in dystonia via the gut-brain axis. This exploratory study investigates the composition of the gut micr
Cultural elaboration and differentiation flourished-witness the extraordinary wealth and variety of social and cultural forms across Africa today. Political experiments included the construction of polyethnic polities, the emergence of cities and empires, the elaboration of priestly and royal power. In the context of a Church in construction, it is not surprising that the first phase of Christian
Renal cell carcinomas (RCCs) are a group of tumours that arise from the nephron within the kidney. They are characterised by an indolent growth pattern and do not display overt clinical symptoms in patients with early to locally advanced tumours. Furthermore, the global average age of a RCC patient at diagnosis is 75 and they usually present with co-morbidities that may render invasive surgical/bi
Samtidigt som bilen är själva grunden för det sätt vi förflyttar oss i samhället, utgör bilismen den främsta orsaken till transportsektorns negativa miljö- och hälsoeffekter. Denna avhandling handlar om politiska försök att gå bortom bilen, mot en mer hållbar form av mobilitet. Hållbar mobilitet eller hållbara transporter, som är den mer använda termen i Sverige, har de senaste decennierna kommitTransport policies in Western Europe are increasingly framed in terms of sustainable mobility. This is a response to an urgent need to tackle adverse consequences of the transport system and implies changes in discourses related to transport. Exploring sustainable mobility is a fruitful way of studying discursive development in a policy field historically connected to priorities radically differen
AIMS: The CHA2DS2VASc score is used to evaluate the risk of thromboembolic events in patients with non-valvular atrial fibrillation. We assessed the prognostic yield of CHA2DS2VASc for new-onset atrial fibrillation, cardiovascular morbidity and mortality in a non-atrial fibrillation population.METHODS: We analysed a population-based cohort of 22,179 middle-aged individuals with (n = 3542) and with
In this work, we present measurements of the intensity-dependent photoelectron spectrum of Kr irradiated by the FLASH FEL tuned to a photon energy of 25.8 eV. Intensity dependent photoelectron spectra were obtained with the aid of a Velocity Map Imaging (VMI) spectrometer. As the FEL photon energy is close to threshold, two photon sequential double ionization is favoured. The number of open channe
The class of [NiFe]-hydrogenases comprises oxygen-sensitive periplasmic (PH) and oxygen-tolerant membrane-bound (MBH) enzymes. For three PHs and four MBHs from six bacterial species, structural features of the nickel-iron active site of hydrogen turnover and of the iron-sulfur clusters functioning in electron transfer were determined using X-ray absorption spectroscopy (XAS). Fe-XAS indicated surp
We present the results of dynamic in-situ 3D X-ray imaging of methane hydrates microstructure during methane hydrate formation and dissociation in sand samples. Short scanning times and high resolution provided by synchrotron X-rays allowed for better understanding of water movement and different types of gas-hydrate formation. Complementing previous observations, we conclude that the process of g
The role of natural marine aerosols in the global climate system remains understudied and uncertain. This is true for the emissions of natural volatile compounds over the ocean, the oxidation of said compounds and their impact on particle formation and particle growth. In this thesis, the emission, chemistry and aerosol particle processes relating to these compounds were studied using different pr
Energy conservation measures (ECMs) are often chosen for their immediate benefits, such as suitability to past/current climate conditions and rapid economic returns. However, the longevity of these ECMs poses a risk of becoming outdated or ineffective as climate change alters the very climatic parameters they were designed for. This paper provides insight into the foresight required when selecting
