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. The aim of this article is to provide an up-to-date overview on paediatric haemophilia care in the world, with emphasis on medical treatment, rehabilitation, and orthopaedic surgery. The reason these specific professions caregivers are included is that over 90% of bleeding episodes in people with haemophilia (PWH) occur within the musculoskeletal system; and of these 80% of bleedings occur in jo
The popliteal artery (PA) is, after aorta, the most common site for aneurysm formation. Why the PA is more susceptible than other peripheral muscular arteries is unknown. We hypothesized that the wall composition, which in turn affects wall properties, as well as the circumferential wall stress (WS) imposed on the arterial wall, might differ compared to other muscular arteries. The aim was to stud
It is recommended that intervention thresholds should be based on absolute fracture risk, but there is a large variation in hip fracture incidence from different regions of the world. The aim of this study was to examine heterogeneity of hip fracture probability in different regions from recent estimates of hip fracture incidence and mortality to adjust intervention thresholds. Ten-year probabilit
The apparent permeability index is widely used as part of a general screening process to study drug absorption, and is routinely obtained from in vitro or ex vivo experiments. A classical example, widely used in the pharmaceutical industry, is the in vitro Caco-2 cell culture model. The index is defined as the initial flux of compound through the membrane (normalized by membrane surface area and d
The decay of core-excited electronic states in free 1,3 trans butadiene molecules has been studied using high-resolution synchrotron radiation and electron spectrometry. The core-level energy shift between the terminal and central carbon atoms is 0.64 eV making selective excitation of core electrons from these atoms possible. Resonant excitation to the au(*) valence state leads to autoionizing dec
The Integral Dictionary is a comprehensive lexical network for French, English, German, Italian, and Spanish. It is based on componential semantics and lexical functions. The network structure superimposes two graphs. A first graph consists of a hierarchy of concepts divided into classes and themes where the words form the terminal nodes of the graph. A second graph links the words together using
The aim of this study was to determine the threshold of fracture probability at which interventions became cost-effective in men and women, based on data from Sweden. We modeled the effects of a treatment costing $500 per year given for 5 years that decreased the risk of all osteoporotic fractures by 35% followed by a waning of effect for a further 5 years. Sensitivity analyses included a range of
The solution properties of two water-soluble polymers, poly(acrylic acid) (PAA), covalently labeled with the fluorescent hydrophobic dye naphthalene (Np), have been investigated in water:organic solvent mixtures. The naphthalene chromophores have been randomly attached, onto the polymer, with two different degrees of labeling. Fluorescence measurements (steady-state and time-resolved) have been us
Aquaporins of the TIP subfamily (Tonoplast Intrinsic Proteins) have been suggested to facilitate permeation of water and ammonia across the vacuolar membrane of plants, allowing the vacuole to efficiently sequester ammonium ions and counteract cytosolic fluctuations of ammonia. Here, we report the structure determined at 1.18 Å resolution from twinned crystals of Arabidopsis thaliana aquaporin AtT
Background. HIV-infected mothers can transmit their infection to their children in utero or at delivery (vertical transmission). There have been cases of children who were reported as acquiring infection vertically and later clearing the infection. We report the frequency of this phenomenon in a European cohort study. Methods. In four centres of the European Collaborative Study of children born to
This report identifies fundamental problems to be addressed in order to build relevant clinical tests of human balance while standing. The stated purpose of these tests is identification of lesion site and/or definition of functional balance deficits in a specific patient. During a recent consensus meeting (ESCEBD), 60 researchers and experienced clinical users of posturography (14 European countr
OBJECTIVE—The purpose of this study was to evaluate the metabolic effectiveness, safety, and tolerability of nateglinide in subjects with impaired glucose tolerance (IGT) and to identify a dose appropriate for use in a diabetes prevention study. RESEARCH DESIGN AND METHODS—This multicenter, double-blind, randomized, parallel-group, fixed-dose study of 8 weeks’ duration was performed in a total of
The cone snail is the only invertebrate system in which the vitamin K-dependent carboxylase (or gamma-carboxylase) and its product gamma-carboxyglutamic acid (Gla) have been identified. It remains the sole source of structural information of invertebrate gamma-carboxylase substrates. Four novel Gla-containing peptides were purified from the venom of Conus textile and characterized using biochemica
Att ha en religion, tro eller övertygelse är en absolut mänsklig rättighet och får inte begränsas på något vis. Friheten att utöva sin religion eller övertygelse är också en skyddad rättighet, dock behöver den begränsas för att inte kränka andra individers friheter och rättigheter. I vilken utsträckning en arbetsgivare kan begränsa en arbetstagares religiösa uttryck på arbetsplatsen är ett omdebat
The implementation of iris scan technology in the context of humanitarian financial assistance in UNHCR-run refugee camps raises an array of legal questions. While the collection and storage of biometrical data in other contexts is often accompanied by a critical discussion about data protection and privacy concerns, the use of such data in humanitarian settings is often left uncontested. The in-d
Geokronologi och paleomagnetiska studier är de viktigaste verktygen för paleogeografiska rekonstruktioner kring hur kontinenter fårhållit sig relativt till varandra under geologisk tid. Genom att jämföra s.k. polvandringskurvor och tidpunkter för storskaliga magmatiska händelser mellan olika krustala block (kontienter/kratoner) kan vi få en bättre förståelse av hur dessa block förhöll sig relativtRobust geochronology and well-constrained paleopoles are the main tools for paleogeographic reconstructions. Through the completion of so called barcode diagrams (matching of coeval events of mafic magmatism between blocks) and determination of the apparent polar wander paths, these studies provide a better understanding of the position of continents and supercontinents in the past. The robust U–P
Organometallic analogs of chloroquine (CQ) are of interest as drug candidates that may be able to overcome the widespread chloroquine resistance developed by malaria parasites. Two new chromium arene CQ-analogs: [η(6)-N-(7-chloroquinolin-4-yl)-N'-(2-dimethylamino-methylbenzyl)-ethane-1,2-diamine]tricarbonylchromium 4 and [η(6)-N-(7-chloroquinolin-4-yl)-N'-(2-dimethylaminobenzyl)-ethane-1,2-diamine
The focus of this study is on the privatisation process in a state of transition. This study set out to distinguish the essential factors which explain and promote the emergence of a dominant private sector. From that, two different approaches to privatisation are examined and analysed; the Washington consensus and the Evolutionary approach. The Washington consensus emphasises on the speed of the
