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Organiserande av stöd och service till barn med funktionhinder: Om projektnät, språkliga förpackningar och institutionella paradoxer

Avhandlingen är en studie av hur stöd och service organiseras kring fyra barn med funktionshinder och deras familjer. I denna service är normalt flera olika formella organisationer involverade, som barnhabilitering, förskola/skola/särskola, hjälpmedelscentral, assistentorganisationer, sjukvård m fl. Dessutom kan barnets och familjens situation vara komplicerad på många sätt. Själva funktionshindreThis study explores the organising of services for disabled children and their families in Sweden. It is based on 83 interviews with parents and involved staff surrounding four disabled children, with both physical and intellectual disabilities, and between two and nine years old. Further, 15 meetings between parents and staff were observed, primarily serving as background material. The service pr

A cryptic EWSR1::DDIT3 fusion in myxoid liposarcoma: Potential pitfalls with FISH and cytogenetics

Myxoid liposarcoma (MLS) is molecularly characterized by fusions involving the DDIT3 gene in chromosome band 12q13; the fusion partner is FUS in band 16p11 in 90–95% of the cases and EWSR1 in band 22q12 in the remaining 5–10%. Hence, molecular studies, often fluorescence in situ hybridization (FISH) for DDIT3 rearrangement, are useful for establishing a correct diagnosis. Although all MLS tumors s

Vertical transmission of a nematode from female lizards to the brains of their offspring

Parasites have evolved a diversity of lifestyles that exploit the biology of their hosts. Some nematodes that parasitize mammals pass via the placenta or milk from one host to another. Similar cases of vertical transmission have never been reported in avian and nonavian reptiles, suggesting that egg laying may constrain the means of parasite transmission. However, here we report the first incidenc

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In this clinical case, the importance of early detection of Hurler syndrome for outcomes of stem cell transplantation in this patient population is illustrated. Nowadays, children with Hurler syndrome can be treated with stem cell transplantation, but the results largely depend on the moment of treatment. If the procedure is initiated in an early stage of disease, better results can be obtained. T

Evidence against atomiclike resonant auger decay in N2 doubly excited core states by high-resolution experiments

The resonant Auger decay spectra associated with doubly excited core-hole states near the N 1s threshold in the nitrogen molecule was measured. Electron-yield spectrum was obtained by setting a kinetic-energy window at 384 eV and scanning across the threshold region. At ground 410, 414, and 416 eV, photon energy, three dominant structures were observed. The increased signal-to-background ratio, in

Nuclear motion driven by the Renner-Teller effect as observed in the resonant Auger decay to the X̃2Π electronic ground state of N2O+

The nuclear dynamics in the Nt 1s→π* in nitrous oxide was studied using the high resolution resonant Auger spectroscopy and ab initio quantum chemical calculations. For probing the nuclear motion of the system in the core-excited state, the frequency detuning technique was used. The results showed changes in vibrational structure for the Auger decay spectra and a strong influence of nuclear motion

Spherical Wave Array Based Positioning for Vehicular Scenarios

Smart vehicles are emerging as a possible solution for multiple concerns in road traffic, such as mobility and safety. This work presents radio localization methods based on simultaneous direction of arrival (DOA), time-delay, and range estimation using the SAGE algorithm. The proposed methods do not rely on external sources of information, such as global navigation satellite systems (GNSS). The p

Optimized vs. Standard Automated Peritoneal Dialysis Regimens (OptiStAR) : Study protocol for a randomized controlled crossover trial

Background: It has been estimated that automated peritoneal dialysis (APD) is currently the fastest growing renal replacement therapy in the world. However, in light of the growing number of diabetic patients on peritoneal dialysis (PD), the unwanted glucose absorption during APD remains problematic. Recent results, using an extended 3-pore model of APD, indicated that large reductions in glucose

Ecological traits interact with landscape context to determine bees' pesticide risk

Widespread contamination of ecosystems with pesticides threatens non-target organisms. However, the extent to which life-history traits affect pesticide exposure and resulting risk in different landscape contexts remains poorly understood. We address this for bees across an agricultural land-use gradient based on pesticide assays of pollen and nectar collected by Apis mellifera, Bombus terrestris

Senescence-associated β-galactosidase activity in the developing avian retina

BACKGROUND: Senescence-associated β-galactosidase (SA-β-GAL) histochemistry is the most commonly used biomarker of cellular senescence. These SA-β-GAL-positive cells are senescent embryonic cells that are usually removed by apoptosis from the embryo, followed by macrophage-mediated clearance.RESULTS: Some authors have proposed that SA-β-GAL activity in differentiated neurons from young and adult m

Arsenic exposure and biomarkers for oxidative stress and telomere length in indigenous populations in Bolivia

BACKGROUND: Women living in the Bolivian Andes are environmentally exposed to arsenic, yet there is scarce information about arsenic-related effects in this region. Several biomarkers for telomere length and oxidative stress (mitochondrial DNA copy number, mtDNAcn; 8-Oxo-2'-deoxyguanosine, 8-oxo-dG; and 4-hydroxy nonenal mercapturic acid, 4-HNE-MA) have been previously linked to arsenic, and some

Lexical transfer in second- and third language early vocabulary acquisition

Comparing lexical transfer in second- and third language early vocabulary acquisition The present study compared 30 functional English monolinguals and 30 highly proficient (CEFR C1+) Swedish–English bilinguals. They acquired vocabulary in a pseudo-language derived from typologically unrelated Finnish. None of the participants had productive proficiency in Finnish although for societal reasons the

Real-Time Personalized Atrial Fibrillation Prediction on Multi-Core Wearable Sensors

In the recent Internet-of-Things (IoT) era where biomedical applications require continuous monitoring of relevant data, edge computing keeps gaining more and more importance. These new architectures for edge computing include multi-core and parallel computing capabilities that can enable prevention diagnosis and treatment of diseases in ambulatory or home-based setups. In this article, we explore

Assembling large genomes : Analysis of the stick insect (Clitarchus hookeri) genome reveals a high repeat content and sex-biased genes associated with reproduction

Background: Stick insects (Phasmatodea) have a high incidence of parthenogenesis and other alternative reproductive strategies, yet the genetic basis of reproduction is poorly understood. Phasmatodea includes nearly 3000 species, yet only the genome of Timema cristinae has been published to date. Clitarchus hookeri is a geographical parthenogenetic stick insect distributed across New Zealand. Sexu

Global proteomic characterization of microdissected estrogen receptor positive breast tumors

We here describe two proteomic datasets deposited in ProteomeXchange via PRIDE partner repository [1] with dataset identifiers PXD000484 (defined as "training") and PXD000485 (defined as "test") that have been used for the development of a tamoxifen outcome predictive signature [2]. Both datasets comprised 56 fresh frozen estrogen receptor (ER) positive primary breast tumor specimens derived from

Validating the existence of the supercraton Vaalbara in the Mesoarchaean to Palaeoproterozoic

Det är allmänt känt att kontinenter under Jordens historia har separerat och kolliderat i ett cykliskt förlopp vilket har lett till existensen av större landmassor, superkontinenter eller superkratoner under vissa tidsperioder. En av de tidigaste föreslagna superkratonerna är Vaalbara, som sedan 1960-talet har ansetts bestå av Kaapvaalkratonen i södra Afrika och Pilbarakratonen i västra AustralienIn this thesis, the longevity and continuity of the Vaalbara supercraton is addressed in six papers aimed at placing new temporal and spatial constraints onthe supercraton in the Mesoarchean to Paleoproterozoic. It has been speculated since the 1960’s that the Kaapvaal Craton in southern Africa, together withthe Pilbara Craton in Western Australia existed as a single landmass during the Precambria

Tools for protective lung ventilation. The elastic pressure-volume curve and aspiration of dead space

Popular Abstract in Swedish Mekanisk ventilation kan medföra "ventilationsinducerad lungskada" (VILI), som kan öka sjuklighet och dödlighet i samband med akut lungskada (ALI). Flera ventilationssätt har föreslagits för att undvika VILI, men inte slutgiltigt utvärderats. En princip är att öka alveolär ventilation och CO2-elimination genom att minska ventilationen av de skadliga rummet, dead space. Ventilator-induced lung injury (VILI) may contribute to morbidity and mortality of acute lung injury (ALI). Lung protective ventilation (LPV), that reduces VILI, may involve low tidal volume (Vt). Particularly low Vt is possible if dead space ventilation is reduced e.g. by aspiration of dead space gas (ASPIDS). ASPIDS implies that gas rich in CO2 during expiration is aspirated through a separate c

Present limitations of models for predicting chloride ingress into reinforced concrete structures

Models to predict chloride ingress are numerous but all of them have serious limitations that restrict the present use for long term predictions. An overview is given of the fundamental differences between various models, from those based on Fick's 2nd with constant or time-dependent diffusion coefficients and surface chloride contents, to those based on chloride transport equations with or withou