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Role of Wnt-5a in breast cancer

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen hos västerländska kvinnor. I Sverige kommer var tionde kvinna att drabbas av bröstcancer, vilket motsvarar drygt 5000 kvinnor om året. Dödligheten i bröstcancer är 30%. Detta innebär att en tredjedel av de som drabbas kommer att dö av sin sjukdom. Det är dock inte själva tumören i bröstet som dödar eftersom denna i princip alltBreast cancer is one of the most common cancer forms in the industrialized world. Only in Sweden, nearly 6000 women are diagnosed with breast cancer each year and 1/3 of them eventually succumb to the disease. Wnts are a family of genes that have been implicated in many human tumours, so far mainly studied in colorectal cancer where activated Wnt signalling occurs in a vast majority of tumours. Wh

Binding of plasma proteins by Staphylococcus epidermidis: characterisation of protein-protein interactions

Popular Abstract in Swedish Sammanfattning på svenska Stafylokocker ingår i vår normala bakterieflora på hud och slemhinnor, men kan också ge upphov till infektioner. Staphylococcus aureus, den gula stafylokocken, är den vanligaste orsaken till sårinfektioner och "sjukhussjuka", och orsakar allvarliga djupa infektioner i ben, hjärta och andra inre organ, samt blodförgiftning. S. epidermidis, den vCoagulase-negative staphylococci (CoNS), in particular, Staphylococcus epidermidis, have emerged as major nosocomial pathogens associated with infections of implanted medical devices. These organisms, which are among the most prevalent bacteria of the human skin and mucous membrane microflora, gain access to the surface of the implant at the insertion. However, the subsequent infection may erupt u

The transitional landscape of urbanity - territorial and visual challenges in the urban periphery of Malmö

The greater cities’ outer transitional zones are ephemeral and dynamic. With Malmö (Sweden) as an example this paper discusses how coastal and agricultural landscapes in the urban fringe can develop into something new and closer to actual needs of the inhabitants. This is done by opening up for a use of new concepts when describing these areas, for example among planners/designers and exploiters.

Constructing sustainability: consumer Roles and Contributions in Shaping Ethical Consumption within Online Communities

This study aims to explore the complexities of ethical consumption and identify the factors shaping consumers’ sustainability decisions through online discussions. It seeks to understand how consumers articulate concerns, analyzing topics like the ethical consumption gap, governmentality, responsibilization etc. The research aims to drive positive change in both individual behaviors and societal

Dataportabilitet och företagshemligheter - Balansgången mellan dataportabilitet och företagshemligheter

Uppsatsen analyserar samspelet mellan rätten till dataportabilitet enligt EU:s dataskyddsförordning (GDPR) med skyddet för företagshemligheter enligt företagshemlighetsdirektivet. Syftet är att undersöka hur dess två regelverk påverkar varandra och hur en balans kan uppnås mellan individens rätt till sin data och företagens behov av att skydda känslig information. Uppsatsen klargör vad rätten tillThe thesis analyzes the interplay between the right to data portability under the EU General Data Protection Regulation (GDPR) and the protection of trade secrets under the Trade Secrets Directive. The aim is to examine how these two frameworks interact with each other and how a balance can be achieved between an individual's right to their data and the need for businesses to protect sensitive

Impact of probiotic dairy- and plant-based yogurt on gut health in healthy individuals

Kan växtbaserad yoghurt med tillsatta probiotiska bakterier gynna tarmfloran? Tarmfloran har kopplats till både hälsa och sjukdom, och genom att äta probiotiska bakterier hoppas man kunna gynna de goda bakterierna i tarmen, som får oss att må bättre. I den här undersökningen har en växtbaserad och en mjölkbaserad yoghurt med tillsatta probiotiska bakterier ätits i 4 veckor och deras effekt på taIn recent years, the development of meat-and dairy analogues has increased to meet demands from consumers, as well as serving as environmentally beneficial alternatives to meat and dairy. While traditional plant-based diets based on whole-foods have been shown to lead to beneficial health effects, the new analogues differ vastly from the ingredients of a whole foods, plant-based diet and the effec

Lojalitet och utveckling - en studie kring organisationers utvecklingsmöjligheter genom förståelse för lojalitet och dess manifestationer

Lojalitet är ett ämne som är aktuellt idag och har även varit så tidigare. Definitionerna av lojalitet är många och i Sverige har vi lagstiftat om arbetstagarens lojalitetsplikt mot arbetsgivaren. Lojalitet beskrivs som en känsla som kan anta genuin eller formell form och kan manifesteras på många olika sätt. Individen, organisationen och samhället runt individen dikterar hur denne manifesterar si

God's own country in trouble a comparitive content analysis of health and disaster management policies on the 2018 floods in Kerala, India

In 2018, the Indian state of Kerala experienced devastating floods that killed 433 people and displaced 1.4 million. The floods are becoming more frequent since then due to climate change. In this research, we compared international frameworks on health and disaster with national and state documents. We used content analysis and applied Walt and Gilson's framework of health policy analysis to

Artificial Intelligence and Gender Equality: A Study on Legal Scholars’ Understanding of Gender Discrimination and Suggested Solutions

Syftet med denna uppsats är att identifiera den rådande diskursen inom juridisk forskning på området artificiell intelligens (AI) och genus, och att diskutera för- och nackdelar med de lösningar forskare presenterat i relation till substantiell jämställdhet. De rekommenderade lösningarna identifieras genom en systematisk juridisk litteraturgenomgång av AI och genus. Genom att tillämpa teorin om soThe thesis aims to identify the dominant narrative within the legal research field of Artificial Intelligence (AI) and discuss the merit of the prevalent solutions offered by scholars in relation to substantive gender equality. The thesis finds the solutions from a systematic legal literature review covering AI and gender. It develops an analytical framework by applying the theory of social change

Anorectal malformations and perineal hemangiomas : The Arm-Net Consortium experience

Aim: Perineal hemangiomas rarely occur in patients with anorectal malformations (ARMs), but they can pose a significant challenge and warrant special attention. Surgical incision of posterior sagittal anorectoplasty (PSARP) may involve the hemangioma site resulting in hemorrhage, damage to blood supply, leading to complications and adversely affecting outcome. The aim of this study was to review t

Characterisation of non-coagulating milk and effects of milk composition and physical properties on rennet-induced coagulation in Swedish Red Dairy Cattle

Non-coagulating milk is a serious problem in the cheese industry, since it decreases cheese yield, resulting in decreased economic output. This study evaluated rennet-induced coagulation properties and composition of milk from individual Swedish Red Dairy Cattle. Milk samples from 679 individual cows were rheologically evaluated, of which 18.1% of the cows produced non-coagulating milk and 18.9%

A novel diagnostic approach to patients with myoclonus

Myoclonus is a hyperkinetic movement disorder characterized by brief, involuntary muscular jerks. Recognition of myoclonus and determination of the underlying aetiology remains challenging given that both acquired and genetically determined disorders have varied manifestations. The diagnostic work-up in myoclonus is often time-consuming and costly, and a definitive diagnosis is reached in only a m

D-serine influences synaptogenesis in a P19 cell model

Recently, d-serine has been identified as an important NMDA-receptor co-agonist, which might play a role in central nervous system development. We investigated this by studying rat P19 cells, an established model for neuronal and glial differentiation. Our results show that (1) the d-serine synthesizing enzyme serine racemase was expressed upon differentiation, (2) extracellular d-serine concentra

Eye movement disorders and neurological symptoms in late-onset inborn errors of metabolism

Inborn errors of metabolism in adults are still largely unexplored. Despite the fact that adult-onset phenotypes have been known for many years, little attention is given to these disorders in neurological practice. The adult-onset presentation differs from childhood-onset phenotypes, often leading to considerable diagnostic delay. The identification of these patients at the earliest stage of dise

Expanding the ADCY5 phenotype toward spastic paraparesis : Amutation in the M2 domain

Patients with an ADCY5 gene mutation reveal a heterogenous clinical presentation including axial hypotonia, motor milestone delay, fluctuating dyskinesias, dystonia, and/or myoclonus with episodic exacerbations during drowsiness and sleep.1,2 Phenotype-genotype correlations and somatic mosaicism are suggested to explain the wide phenotypic spectrum.1 The ADCY5 gene encodes 1 of 9 membrane-bound ad