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Current knowledge of the molecular changes induced by dopamine denervation and subsequent treatment with L-DOPA is based on studies performed on relatively acute and young animal models of parkinsonism. It is highly warranted to ask how well these models simulate the state of chronic denervation and sustained L-DOPA pharmacotherapy which are typical of advanced Parkinson's disease. This study inve

We present a Bayesian approach to particle identification (PID) within the ALICE experiment. The aim is to more effectively combine the particle identification capabilities of its various detectors. After a brief explanation of the adopted methodology and formalism, the performance of the Bayesian PID approach for charged pions, kaons and protons in the central barrel of ALICE is studied. PID is p

In order to reinstate interest and motivation for learning foreign languages (FLs) other than English, the Swedish government has recently reformed the admissions system to higher education. Upper secondary students who continue with the FL learnt in secondary school are rewarded with extra credits that considerably enhance their grade point average (GPA). The purpose of this interview-based study

Traditionally, design analysts are solely responsible for all computerbased design analysis (CBDA). CBDA refers to quantitative design analyses utilising computational tools in the engineering design and development of technical solutions. There are currently limited insights into and knowledge of tools and methods needed to facilitate the use of CBDA by engineering designers. In order to gather i

Background: Long waiting times have been a significant problem in theSwedish health care system. A lack of matching of pathways of care has ledto long waiting times for patients, increasing medical risk and contributingtowards less effective capacity utilisation. There are different pathways into theelective healthcare system in Sweden, some via referral from a physician andothers via referral wri

The heterogeneity of common variable immunodeficiency (CVID) calls for a classification addressing pathogenic mechanisms as well as clinical relevance. This European multicenter trial was initiated to develop a consensus of 2 existing classification schemes based on flowcytometric B-cell phenotyping and the clinical course. The clinical evaluation of 303 patients with the established diagnosis of

Popular Abstract in SwedishMed utgångspunkt i två forskningsfält – strategisk kommunikation och urbanforskning – analyseras och problematiseras Malmös omvandling från arbetarstad till kunskapsstad. Hur har Malmös förändring genomdrivits? Vilka resonemang och föreställningsramar har styrt omvandlingen? Vilka kommunikativa strategier har använts för att projicera den önskvärda (själv)bilden av en ku

Popular Abstract in Swedish Västeuropeiska stater har blivit alltmer mångkulturella. Migrationsflöden från fattigare delar av välden har bidragit till att länder som tidigare uppfattade sig själva som homogena, uppvisar en allt högre grad av kulturella, etniska och religiösa olikheter. Förespråkare för mångkulturalism har argumenterat att ett sätt att hantera gruppers olikheter är att tolerera der

This study explored how final-year psychology students experienced their initial exposure to virtual reality (VR) relaxation using a scientifically developed application designed to promote emotional well-being and stress reduction. The aim was to understand how VR is perceived as a space for emotional regulation, embodiment, and reflection within psychological education. A qualitative exploratory

The Quercetum Chorus Workshop introduced students in the Cal Poly Pomona Interdisciplinary Paris Study Abroad Program (CPP IPSAP) to methods of deepening human-tree relations through sound, drawing and movement. Students applied a multi-sensory approach to knowing trees by attuning to their frequencies, textures, shapes, and movements. They were invited to reimagine trees as more-than-human bodies

Currently, many research studies are exploring opportunities for the use of novel fuels and of their blends with conventional, i.e. petroleum-based fuels. To pave the way for their acceptance and implementation in the existing energy market, a comprehensive knowledge about their combustion properties is inevitable, among others. Within this context, alcohols, with butanol in particular, are consid

Carriers of the hydroxysteroid 17-β dehydrogenase 13 (HSD17B13) gene variant (rs72613567:TA) have a reduced risk of NASH and cirrhosis but not steatosis. We determined its effect on liver histology, lipidome, and transcriptome using ultra performance liquid chromatography-mass spectrometry and RNA-seq. In carriers and noncarriers of the gene variant, we also measured pathways of hepatic fatty acid

Resum:The role of the family in both individual social status attainment and labor careers during industrialization was questioned by the Modernization theory. Accordingly, familial nuclearization was argued to be one of the causes. However, little has been said on this topic regarding societies in which stem or joint families were important as in the case of Southern Europe. This article studies

OBJECTIVES: To report the long-term safety and efficacy of BAY 81-8973 in the LEOPOLD Kids extension phase.METHODS: Patients received BAY 81-8973 (25-50 IU/kg) at least twice weekly. The primary endpoint was safety, assessed in all patients who entered the extension phase (n = 82). Efficacy endpoints were assessed in patients without high-titre inhibitors/immune tolerance induction (n = 67).RESULT

Feedback loops are among the core notions in systems thinking – and the various fields of theory and practice that draw on it, including systemic design. We use these notions to develop methodological approaches, conceptualise processes, assess the adequacy of solutions, and anticipate how the design object may interact with its immediate surroundings and beyond. In my presentation, I discuss the

Directed evolution has revolutionized protein engineering. Still, enzyme optimization by random library screening remains sluggish, in large part due to futile probing of mutations that are catalytically neutral and/or impair stability and folding. FuncLib is a novel approach which uses phylogenetic analysis and Rosetta design to rank enzyme variants with multiple mutations, on the basis of predic

Med utgångspunkt i repertoar med rötter i folkmusik från Iberiska halvön fortsätter Groupa sitt arbete med att skapa helt nya musikaliska uttryck baserade på traditionsmusik. Detta är det fjärde albumet i serien Kind of Folk, här i samarbete med spanska och portugisiska musiker. Medverkar gör slagverksduon Ttukunak Txalaparta, bestående av Maika Gomez och Sara Gomez, sångerskan och slagverkaren Va