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BACKGROUND: Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZNF365 (10q21.2) as risk factors for breast cancer among BRCA1 and BRCA2 mutation carriers, respectively. We explored associations with ovarian cancer and with breast cancer by tumor histopathology for these variants in mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). METHO
BACKGROUND: Patients who misuse alcohol are at increased risk for surgical complications. Four weeks of preoperative abstinence decreases the risk of complications, but practical approaches for early preoperative identification of alcohol misuse are needed. OBJECTIVE: To evaluate whether results of alcohol screening with the Alcohol Use Disorders Identification Test - Consumption (AUDIT-C) questi
The aim of the present study was to examine parity and age at first childbirth, in relation to the risk of specific breast cancer subgroups. A prospective cohort, The Malmö Diet and Cancer Study, including 17,035 women were followed with linkage to Swedish Cancer Registry until December 31, 2004. A total of 622 incident breast cancers were diagnosed during follow-up and were evaluated regarding in
Syftet med uppsatsen är att undersöka hur familjevåld påverkar bedömningen av barnets bästa i frågor om vårdnad, boende och umgänge. Med våld avses våld riktat mot någon annan i familjen än barnet. Jag har använt mig av tre frågeställningar för att lyfta fram vilken betydelse våldet har för barnet. Den första frågeställningen är mer övergripande och handlar om hur våldet påverkar barnets bästa. DeThe aim of this thesis is to examine how domestic violence affects the decision of what is in the best interest of the child with regards to parental authority judgments. In this thesis the term domestic violence refers to all violence towards another family member except the child himself. The thesis is built upon three questions in order to highlight the impact domestic violence has upon the dec
Den tilltalades tidigare brottslighet kan i svensk rätt påverka påföljdsbestämningen för ny brottslighet, dvs. straffmätning och påföljdsval, på främst tre sätt. I första hand kan den tidigare brottsligheten beaktas genom ett skärpt påföljdsval. I andra hand har rätten möjlighet att förklara villkorligt medgiven frihet förverkad. I sista hand finns det genom straffskärpning möjlighet att förlänga
Objective : To determine the association between health-risk behaviors and a history of sexual coercion among urban Chinese high school students. Design : A cross-sectional study was performed among 109,754 high school students who participated in the 2005 Chinese Youth Risk Behavior Survey. Data were analyzed for 5,215 students who had experienced sexual intercourse (1,483 girls, 3,732 boys). Mul
Objective. Several classification systems have been launched to characterize Barrett's esophagus (BE) mucosa using magnification endoscopy with narrow band imaging (ME-NBI). The good accuracy and interobserver agreement described in the early reports were not reproduced subsequently. Recently, we reported somewhat higher accuracy of the classification developed by the Amsterdam group. The critical
Traditional measures for improved traffic safety need to be complemented by modern technologies in the struggle to reduce the consequences of traffic accidents all over the world. This thesis introduces the Loyal Speed Adaptation (LSA) function based on recent developments in the area of Intelligent Transport Sys-tems to support the vehicle drivers in not using inappropriate or excessive speeds, w
Sammanfattning Sedan den första november 2008 har metoden för framställning av muntlig bevisning i hovrätt ändrats. Med anledning av reformen ”En modernare rättegång” moderniserades rättegången i hovrätten. Moderniseringen innebar bland annat att ljud- och bildupptagning som gjorts i tingsrätten, i regel spelas upp som muntlig bevisning i hovrätten. Nu finns förslag på att den delen av hovrättsförSummary Since November 1st 2008, the method of presenting oral testimonies in the Swedish Court of Appeal has changed. Since the reform “More modern court proceedings” the trials in Court of Appeal have become modernized. The modernization meant, inter alia, that audiovisual recording that have been conducted at the Swedish District Courts are, as a rule, played at the Court of Appeal. The recordi
Objective. To analyze the experience of a single centre using stent-grafts for treatment of complicated acute aortic type B-dissections (EVR-ABD). Design. Retrospective analysis of prospectively collected data from patients undergoing EVR-ABD between January 1997 and December 2004. Methods. EVR-ABD was performed in 31 patients (20 males, median age 74. years (IQR: 64-79)). Indications for treatmen
Background Preventive programs for individuals who have high lifetime risks of colorectal cancer may reduce disease morbidity and mortality. Thus, it is important to identify the factors that are associated with hereditary colorectal cancer and to monitor the effects of tailored surveillance. In particular, patients with Lynch syndrome, hereditary nonpolyposis colorectal cancer (HNPCC), have an in
Abstract Determination of the respiratory tract deposition of airborne particles is critical for risk assessment of air pollution, inhaled drug delivery, and understanding of respiratory disease. With the advent of nanotechnology, there has been an increasing interest in the measurement of pulmonary deposition of nanoparticles because of their unique properties in inhalation toxicology and medicin
We present an evaluation of a nested high-resolution Goddard Earth Observing System (GEOS)-Chem chemistry transport model simulation of tropospheric chemistry over tropical South America. The model has been constrained with two isoprene emission inventories: (1) the canopy-scale Model of Emissions of Gases and Aerosols from Nature (MEGAN) and (2) a leaf-scale algorithm coupled to the Lund-Potsdam-
Background., Hypertrophic cardiomyopathy is a common cause of sudden death in children. In this study, we aimed to identify clinical measures for stratification of this risk in childhood. Patients and methods: By means of a retrospective cohort study from six regional centres of paediatric cardiology, we identified 128 patients with hypertrophic cardiomyopathy presenting below 19 years of age, wit
Denna uppsats har via en rättsdogmatisk metod undersökt gällande rätt avseende nödvärn och nödvärnsexcess vid överfall. Den faktiska rättstillämpningen i underrätterna har inte berörts. Rätten till försvarsvåld gentemot brottsliga angrepp tillkommer dels den angripne, dels envar som befinner sig på platsen för angreppet. Denna rätt regleras i nödvärnsstadgandet i 24 kap. 1 § BrB. Skulle omfattninThis paper is, using a legal dogmatic method, analyzing established law regarding self-defence and excessive self-defence. The actual application of the laws in this field is not analyzed. The right of defence against violent criminal attacks is granted to the person being attacked, as well as anyone else nearby. This right is prescribed by 24 chapter 1 § Brottsbalken (the Swedish criminal code)
Title: The discount rate used in the impairment testing of goodwill – A comparison of market-based assessments Seminar date: 2014-05-23 Course: FEKN90, Business Administration: Master Thesis in Corporate Finance, 30 HP Authors: Victor Håkansson and Anton Persson Advisor: Erling Green Key words: Goodwill, impairment testing, discount rate, market-based assessments and IAS 36. Purpose: The pur
Target-specific molecular imaging with radiolabeled antibodies has experienced a rapid growth over the past 20 years, and is now an essential tool to provide information on disease presence and extent. Despite all efforts to detect and control prostate cancer at an early stage, a number of men are still progressing to develop incurable metastatic disease. Because of this, development of new method
The purpose of this paper is to measure living standards for the population of Chocó, Colombia, using four waves of the DHSurveys between 1990 and 2005. Recent maternal history allowed the construction of a pooled dataset of 3.055 children and 779 mothers. The concept of living standards is measured as the ability to ensure child and marriage survival subject to short term economic stress, which i
