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Popular Abstract in English Atherosclerosis is a disease of medium and large sized vessels of our bodies that is mainly characterized by the deposition of lipids in the vessel walls. Increased lipid levels in the blood of an individual, because of lifestyle habits but also because of genetics, can lead to the formation of an “atherosclerotic plaque”. Thus, although lipids are important for the norAtherosclerosis is a chronic inflammatory disease of medium and large vessels of the body which is mainly characterized by the formation of lipid rich plaques within the arterial tissue. It is the most common cause of cardiovascular disease leading to clinical manifestations of coronary artery and cerebrovascular disease. Immune responses targeting modified low density lipoprotein (LDL) play an im

Objective To assess mortality related to exposure to tuberculosis (TB) at home among children in urban areas of Guinea-Bissau. Methods In four suburban areas included in the demographic surveillance system of the Bandim Health Project in Bissau, the mortality of children aged <5 years living with an adult with TB was compared with the mortality of children in the general population. Results Childr

As a country with a high proportion of population and land area in the world, China is in a stage of changing its economic development direction, from the previous extensive economic growth to the intensive economic growth. At the same time, due to the limited total amount of resources and limited environmental bearing capacity on the earth, certain constraints are found in terms of amount and str

Proteinase 3 (PR3) is a neutrophil serine protease stored in the azurophil granules of the promyelocyte and its successors. The protease has been identified as an autoantigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) occurring in patients with Wegener's granulomatosis. To characterize the biosynthesis and processing of human PR3 in a transgenic cellular model, cDNA encoding human pre-p

Most, but not all, studies have found that women with a high urinary 2-hydroxyestrogen (2OHE) to 16 alpha-hydroxyestrone (16 alpha OHE1) ratio are at reduced risk for breast cancer and have a better prognosis. The aim was to identify factors associated with the pre-operative 2OHE to 16 alpha OHE1 ratio and factors that predicted the change in the ratio between the pre-operative visit and first fol

Nearly all mammalian cells express a set of genes known as clock genes. These regulate the circadian rhythm of cellular processes by means of negative and positive autoregulatory feedback loops of transcription and translation. Recent genomewide association studies have demonstrated an association between a polymorphism near the circadian clock gene CRY2 and elevated fasting glucose. To determine

Background: The need for anticoagulation therapy (AC) in patients with subsegmental pulmonary embolism (SSPE) diagnosed by computed tomography of the pulmonary arteries (CTPA) has been questioned, as these patients run low risk for recurrent venous thromboembolism (VTE) during 3 months of follow-up. Whether this applies also to patients with small PE diagnosed with pulmonary scintigraphy has not y

A simple method is tested for scaling climate-extreme results from high resolution regional climate models (RCMs) to time-periods and emission scenarios for which the RCMs have not been run. The 30 yr mean relationships between indicators of extremes (IoEs) and annual mean daily maximum temperature (T-xa) are investigated. Such relationships from the UK Met Office Hadley Centre RCM HadRM3P, along

Screening women for lower genital tract infection with Chlamydia trachomatis is important in the prevention of pelvic inflammatory disease, ectopic pregnancy and infertility. This systematic review aims to state clearly which of the available diagnostic tests for the detection of C. trachomatis would be most effective in terms of clinical effectiveness. The review included all studies published fr

Objective. A low tidal volume can induce alveolar derecruitment in patients with acute lung injury. This study was undertaken to evaluate whether this resulted mainly from the decrease in tidal volume per se or from the reduction in end-inspiratory plateau pressure and whether there is any benefit in raising the level of positive end-expiratory pressure (PEEP) while plateau pressure is kept consta

Background Combined oral contraceptives are classified by the International Agency for Research on Cancer as a cause of cervical cancer. As the incidence of cervical cancer increases with age, the public-health implications of this association depend largely on the persistence of effects long after use of oral contraceptives has ceased. Information from 24 studies worldwide is pooled here to inves

AIMS: To determine the basal pharmacokinetics, lung uptake and plasma cortisol suppression for two commonly prescribed inhaled corticosteroids. METHODS: Twenty-one subjects (13 healthy and 8 mild asthmatic patients) received fluticasone propionate via a chlorofluorocarbon-propelled pressurized metered-dose inhaler (pMDI) (healthy subjects only) and Diskus and budesonide via Turbuhaler, 1000 microg

The people bordering the Arabian Gulf, the Mediterranean Sea and the Red Sea rely more and more on seawater desalination for safe water supply. Desalination has advantages and disadvantages which to a large extent depend on the region, location, technology, impact and amount of fresh water production. In this region, some 60% of all desalination capacity is installed. The three regions areas repre

Background: Different kinds of chronic diseases might imply different dimensions of caregiver burden, not previously described among the caregivers to recipients from the general elder population. Aim: The main objective was to examine differences in burden between the 343 caregivers to persons with different diagnoses. Methods: A group of elderly recipients of informal care (n = 343) from the gen

Förmågan att uppfatta ljus och vilken riktning det kommer från är utomordentligt användbart för djur. Därför är det inte förvånande att denna förmåga återfinns hos i stort sett varje större djurgrupp, även bland de som anses enkla, såsom koraller och spolmaskar. Endast några få djurgrupper har dock, under evolutionens gång, utvecklat verkligt bra ögon som snabbt kan identifiera objekt av djurens eLight-detection provides incomparabaly rapid information at a range of time scales and, consequently, directional photoreception is found in almost every major metazoan clade. Conversely, a much smaller cohort have evolved sophisticated high resolution vision, which facillitates complex tasks via the detection of fast or small objects,. such as courtship and high-speed pursuit of prey. A few such

Traffic engineers around the country often use pre-programmed path plans. However, there is often an uncertainty in how much margin there is in the path plan and if they are trustworthy. The goal of this report is to determine the margin in pre-programmed path plans, using the program AutoTurn, for trucks with a length of 10 meters. This report discusses drive and rest times how both the drive and

Zwitterionic or polar lipids that form lamellar phases swell in the presence of water to take up between 10 and 30 water molecules per lipid. The degree of the water uptake depends both on the state of the alkyl chains, liquid or solid, and on the nature of the polar Group. The swelling behavior has been extensively characterized on the free-energy level through measuring the relation between the

A 30-m-thick sedimentary succession at Leinstranda on the southwestern coast of Br circle divide ggerhalv circle divide ya, northwestern Svalbard, spans the two last glacial-interglacial cycles and reveals information on glacial dynamics, sea-level changes and the timing of these events. We investigated the deposits using standard stratigraphical and sedimentological techniques, together with grou

Background: Global stroke epidemiology is changing rapidly. Although age-standardized rates of stroke mortality have decreased worldwide in the past 2 decades, the absolute numbers of people who have a stroke every year, and live with the consequences of stroke or die from their stroke, are increasing. Regular updates on the current level of stroke burden are important for advancing our knowledge