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Antigenic peptide delivery to antigen-presenting cells using a CD40-coiled coil affinity-based platform

Delivery of antigenic peptides to antigen presenting cells (APCs) such as dendritic cells (DCs) using monoclonal antibodies (mAbs) is an attractive approach to evoke antigen-specific T cell activation and improve drug efficacy. Peptide linkage to mAbs has previously been achieved through genetic fusion, chemical conjugation, nano-engineered platforms and high affinity peptides. In this study, we h

Group A streptococci induce stronger M protein-fibronectin interaction when specific human antibodies are bound

Group A streptococcus (GAS) is a highly adapted, human-specific pathogen that is known to manipulate the immune system through various mechanisms. GAS’ M protein constitutes a primary target of the immune system due to its spatial configuration and dominance on the bacterial surface. Antibody responses targeting the M protein have been shown to favor the conserved C region. Such antibodies (Abs) c

Mode of Coreceptor Use by R5 HIV Type 1 Correlates with Disease Stage: A Study of Paired Plasma and Cerebrospinal Fluid Isolates.

Abstract Through the use of chimeric CXCR4/CCR5 receptors we have previously shown that CCR5-tropic (R5) HIV-1 isolates acquire a more flexible receptor use over time, and that this links to a reduced viral susceptibility to inhibition by the CCR5 ligand RANTES. These findings may have relevance with regards to the efficacy of antiretroviral compounds that target CCR5/virus interactions. Compartme

Antibodies Against Deamidated Gliadin Peptides and Tissue Transglutaminase for Diagnosis of Pediatric Celiac Disease - Diagnostic Performance and Cost in Clinical Practice.

OBJECTIVES: To evaluate diagnostic performance and actual costs in clinical practice of IgG/IgA deamidated gliadin peptide antibodies (DGP) as a complement to IgA antibodies against tissue transglutaminase (tTG) for the diagnosis of pediatric celiac disease (CD). PATIENTS AND METHODS: All consecutive patients <18 years tested for tTG and/or DGP and who underwent duodenal biopsy because of suspec

IgG Binds Escherichia coli Serine Protease EspP and Protects Mice From E. coli O157:H7 Infection

Shiga toxin-producing Escherichia coli O157:H7 is a virulent strain causing severe gastrointestinal infection, hemolytic uremic syndrome and death. To date there are no specific therapies to reduce progression of disease. Here we investigated the effect of pooled immunoglobulins (IgG) on the course of disease in a mouse model of intragastric E. coli O157:H7 inoculation. Intraperitoneal administrat

Development and validation of a machine learning-based model to predict isolated post-challenge hyperglycemia in middle-aged and elder adults : Analysis from a multicentric study

Introduction: Due to the high cost and complexity, the oral glucose tolerance test is not adopted as the screening method for identifying diabetes patients, which leads to the misdiagnosis of patients with isolated post-challenge hyperglycemia (IPH), that is., patients with normal fasting plasma glucose (<7.0 mmoL/L) and abnormal 2-h postprandial blood glucose (≥11.1 mmoL/L). We aimed to develop a

How Can We Persuade Consumers to Purchase More Sustainable Products? A Review of European Legal Developments

A key strategy to support the vision of a circular economy is to promote the consumption of more sustainable products. Both the EU and its Member States have therefore adopted several policies to support this objective. We review these policies and discuss their potential to trigger changes in consumer behaviour. The discussion is focused on five ‘points of intervention’: (1) regulatory choice edi

PROFILING EXTRACELLULAR MATRIX REMODELING IN AN IN VITRO FIBROBLAST AND EPITHELIAL CELL CO-CULTURE MODEL

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease driven by persistent fibroblast activation, abnormal epithelial to mesenchymal signaling and excessive extracellular matrix (ECM) remodeling. Better pre-clinical models are needed to reproduce these processes and to support antifibrotic drug development. This thesis tested whether an in vitro co-culture model

Ovningsprov fvm 1 musiklara

Antagningsprov i teori Folk - och VÈirldsmusikutbildningen Musikhö gskolan i Malmri 1A Skriv ut melodien i A:Stora samt B: tvåstrukna oktaven l.A. Write down the melody inA: the great octave (C) and B: two-line octave (c"). Provexempel A B Antagningsprov i teori Folk - och Våirldsmusikutbildningen Musikhögskalan i Malmö IB Fyll i pauserna samt notv?irden som fattas 1.8. Fill in the pauses and note

https://www.mhm.lu.se/sites/mhm.lu.se/files/ovningsprov_fvm_1_musiklara.pdf - 2026-06-22

Kretzler m cv revised 2021 1 10

CURRICULUM VITAE Matthias Kretzler, M.D. 1 10/09/2020 Matthias Kretzler, M.D. Warner-Lambert/Parke-Davis Professor of Medicine Research Professor, Computational Medicine and Bioinformatics, Medical School University of Michigan Health System 1560 MSRB II, SPC 5676 1150 W. Medical Center Drive Ann Arbor, MI 48109-5676 Tel: (734) 763-6847 kretzler@med.umich.edu https://kretzlerlab.org/ Education and

https://www.ludc.lu.se/sites/ludc.lu.se/files/kretzler_m_cv_revised_2021_1_10.pdf - 2026-06-22

Gender conflict en

Gender and Conflict THEME 2019-2020 The primary objective is to analyze how gender influences the experience of sexual violence by women, men, and other vulnerable populations, including children and gender/sexual minorities among the positions; victims, perpetrators, and bystanders/witnesses, in the aftermath of armed conflict (while these categories are conceptually distinct, any one individual

https://www.pi.lu.se/en/sites/pi.lu.se.en/files/2021-01/gender_conflict_en.pdf - 2026-06-22

A15

Microsoft Word - Tanzania micro final.doc AFRICA IN TRANSITION MICRO STUDY TANZANIA Research Report Prepared by: Gasper C. Ashimogo Aida C. Isinika James E.D. Mlangwa July 2003 2 Table of contents 1. METHODOLOGY ..................................................................................................... 5 1.1 Introduction....................................................................

https://www.keg.lu.se/en/sites/keg.lu.se.en/files/a15.pdf - 2026-06-22

Khm2 info samlad sv dec18

Konsthögskolans galleri, KHM2, Bergsgatan 29, 3 våning Kontakta Sophie eller respektive tekniker om utrustning du vill låna. Kontakta Kristian i god tid för att planera transporten till lokalen. Samtransport från Khm till Galleriet och lastning av föregående utställningar för tillbakatransport till Khm, på måndag f.m. För att få tillträde till byggnaden, hissen och gallerirummet måste du ha ett LU

https://www.khm.lu.se/en/sites/khm.lu.se.en/files/khm2_info_samlad_sv_dec18.pdf - 2026-06-22

BILDGUIDE 1.0

Bildguide för Drupal

 Rekommendationer Janni Lundqvist Vedam
 Användarstöd & suppport Webbavdelningen, sektionen Kommunikation
 2025 Allmänna tips Använd liggande bilde Ha inte förstora bilde Försök att använda originalbilden och dens forma Alla bilder passar inte överall Bör bild finnas på sidan? Tänk på att storlekarna är endast rekommendationer för de element/funktioner som finns i Drupal. En

https://www.webbpublicering.lu.se/sites/webbpublicering.lu.se/files/2025-03/BILDGUIDE%201.0.pdf - 2026-06-22

Insider trading and abnormal return on the Swedish stock market

Title: Insider trading and abnormal return on the Swedish stock market Seminar Date: 2015-05-25 Course: FEKN90 Examensarbete på civilekonomprogrammet (30hp) Authors: Philip Ek and Karin Erlinder Advisor: Rikard Larsson Purpose: By using classifications of different kinds of insiders we wish to en-lighten this area of study with empirical evidence of how insiders on the Swedish Stock Exchange

7 October 2021

Management information The government eased the Covid-19 restrictions last week, but some of them still apply. This means that we continue to stay home when we feel sick, wash our hands often and keep distance. Also, the vice-chancellor’s decision of a plan for a gradual and adapted return to campus still applies until 1 November.Specifically, the following applies during the gradual return at CEC

https://www.cec.lu.se/staff-pages/staff-newsletters/7-october-2021 - 2026-06-21

Häng med på institutionsutflykt! - Cloned

Torsdagen den 30 mars arrangerar fysiska institutionen en gemensam utflykt för alla medarbetare. Vi åker till Utmaningarnas Hus i Malmö för en dag fylld av glädje, inspiration och gemensamma aktiviteter. Program 08.30 Avresa med buss från Sölvegatan utanför Fysicum/ parkeringsplatsen. 09.30 Välkommen och presentation av dagens program med kaffe. 12.00 Gemensam lätt lunch 13.00 Fortsatta gemensamma

https://www.fysik.lu.se/formular/hang-med-pa-institutionsutflykt-cloned - 2026-06-21