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Role of Wnt-5a in breast cancer

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen hos västerländska kvinnor. I Sverige kommer var tionde kvinna att drabbas av bröstcancer, vilket motsvarar drygt 5000 kvinnor om året. Dödligheten i bröstcancer är 30%. Detta innebär att en tredjedel av de som drabbas kommer att dö av sin sjukdom. Det är dock inte själva tumören i bröstet som dödar eftersom denna i princip alltBreast cancer is one of the most common cancer forms in the industrialized world. Only in Sweden, nearly 6000 women are diagnosed with breast cancer each year and 1/3 of them eventually succumb to the disease. Wnts are a family of genes that have been implicated in many human tumours, so far mainly studied in colorectal cancer where activated Wnt signalling occurs in a vast majority of tumours. Wh

Automatic segmentation in CMR - Development and validation of algorithms for left ventricular function, myocardium at risk and myocardial infarction

Popular Abstract in Swedish I denna avhandling presenteras fyra nya metoder för att automatiskt mäta hjärtats förmåga att pumpa ut blod i kroppen, mäta storleken på en hjärtinfarkt samt mäta hur stor del av hjärtmuskeln som riskerade att dö vid hjärtinfarkten. Dessa nya metoder kan användas för att minska skillnader mellan mätningar gjorda av olika läkare, på olika sjukhus och i olika forskargruppIn this thesis four new algorithms are presented for automatic segmentation in cardiovascular magnetic resonance (CMR); automatic segmentation of the left ventricle, myocardial infarction, and myocardium at risk in two different image types. All four algorithms were implemented in freely available software for image analysis and were validated against reference delineations with a low bias and hig

Functional, structural and evolutionary studies on a family of bacterial surface proteins

Popular Abstract in Swedish Hos människan lever en rad mikroorganismer som tillsammans utgör normalfloran. Normalfloran återfinns på alla kroppsytor, det vill säga huden och slemhinnorna i munnen, svalget, magsäcken, tunn- och tjocktarmen, vagina och urinrörsmynningen. Samspelet mellan människokroppen och mikroorganismerna utsätts dagligen för påfrestningar. En sådan naturlig påfrestning är de sjuThis thesis is concerned with a family of bacterial surface proteins expressed by different strains of the anaerobic Gram-positive, commensal and human pathogen Peptostreptococcus magnus. These proteins have been studied with respect to their role in virulence, function, structure, and evolution. Strains isolated from patients with vaginosis have previously been shown to be associated with express

Water-swelling tablets based on hydrophobically modified poly(acrylic acid) - Effects of amphiphiles on swelling and drug release

Popular Abstract in Swedish Vi kommer dagligen i kontakt med läkemedel i olika former, antingen som den kräm som vi smörjer in vårt onda knä eller Treon somliga tar på söndagsmorgon. Många av dessa produkter kan se enkla ut men är ofta resultatet av mycket forskning och för att förstå hur arbetet som utgör den här avhandlingen är kopplat till en Treo, så tänkte jag att vi ska börja med att förklarAn important issue within the pharmaceutical world today is the increasing number of poorly soluble drugs. These often show a low bioavailability and a susceptibility to varying conditions in the intestine. Hydrophobically modified poly (acrylic acid) (HMPAA), commercially available as Pemulen TR2, has shown promising abilities to control the release of especially poorly soluble substances. In thi

Genetic analyses of multiple myeloma and related plasma cell dyscrasias

Popular Abstract in Swedish Elakartade (maligna) blodsjukdomar uppstår i den blodbildande benmärgen, vilken är innesluten i hålrummen i de skelettdelar som kan sägas täckas av en badmössa och en gammaldags baddräkt. En av de celltyper som bildas i benmärgen är plasmacellen, en vit blodkropp som utgör mindre än 2% av benmärgscellerna och som tillverkar specifika antikroppar vid infektioner. Vid monAcquired genetic changes have proved to be of diagnostic and prognostic importance in different hematologic malignancies as well as in some solid tumor types. However, although multiple myeloma (MM), an incurable disease, and its proceeding stage monoclonal gammopathy of undetermined significance (MGUS) are quite common, little is known about the karyotypic features of these plasma cell dyscrasias

A comparison of different orthogonal techniques for the investigation of the conformational stability of NIST mAb in liquid formulations

Antikroppar har ett brett användningsområde med stor potential men det är svårt att skapa stabila lösningar. Den strukturella stabiliteten är en viktig faktor när man väljer läkemedelskandidater, och i de tidiga utvecklingsstadierna görs prediktiva undersökningar för att ta reda på varje kandidats stabilitet och utvecklings-potential. Därmed är det av största intresse att utvärdera hur antikropparA great challenge during early development of medicinal antibodies is to determine the stability of the candidates. This is required to be able to select the candidates with the greatest developability. The stability of the candidates can be estimated using different orthogonal techniques and the aim of this investigation was thus to use orthogonal techniques for the investigation of conformationa

Pancreatic Cancer - Early Detection, Prognostic Factors, and Treatment

Popular Abstract in Swedish Pankreascancer, cancer i bukspottkörteln, är den fjärde vanligaste orsaken till död i cancer och årligen insjuknar cirka 1000 patienter i Sverige. Överlevnaden är kort med en 5-årsöverlevnad på endast 6 procent. Pankreascancer orsakar, förutom lidande, också betydande kostnader för såväl den medicinska vården, som förluster för samhället, exempelvis i form av förtida döBackground: Pancreatic cancer is the fourth leading cause of cancer-related death. Only about 6% of patients are alive 5 years after diagnosis. One reason for this low survival rate is that most patients are diagnosed at a late stage, when the tumor has spread to surrounding tissues or distant organs. Less than 20% of cases are diagnosed at an early stage that allows them to undergo potentially cu

Vindkraft på skogsmark: Privata skogsägares syn på bevarande av biologisk mångfald vid vindkraftsetablering

Privata skogsägares syn på att bevara natur vid installation av vind-kraft i skog De svenska skogarna är stora, nästan 80 procent av Sveriges yta är täckt av skog. Det låter mycket, men skogen har många användningsområden. Den ger oss virke och papper, möj-ligheter till vandring och turism, plats för vindkraft och är hem åt djur och växter. Samtidigt minskar antalet arter på vår planet, och både kThis study aimed to gain a deeper understanding of Swedish small forest owners’ perspectives on ecological compensation on their land in relation to wind farm construction, specifically how their sense of ownership influences their willingness to engage in such activities. To fulfil this aim, semi-structured interviews were conducted with ten private forest owners who had signed agreements for win

Evaluation of Tomodirect for treatment of thoracic and abdominal cases

Sedan 1970-talet har antalet rapporterade cancerfall dubblerats, dels på grund av förändrade levnadsvanor och dels på grund av bättre screeningmetoder som upptäcker cancern i tidigt skede. Tidig upptäckt av cancern i kombination med utvecklad cancerbehandling har bidragit till att risken för att avlida av cancer har minskat. Cancerbehandling sker huvudsakligen genom operation, strålbehandling elleAim: The tomotherapy system offers two radiation techniques, TomoHelical (TH) and TomoDirect (TD). The aim of this master thesis was to evaluate TD as a treatment alternative mainly by comparing TD treatment plans with 3DCRT plans and comparing TD plans with TH plans, separately, in the thoracic and abdominal regions. An additional aim was to examine if the current patient specific quality control

The Recipe for Engagement in a Direct-Action Climate Movement for the Future of Humanity

Vad är det som gör att vissa blir klimataktivister, medan de flesta inte blir det? I studien undersöks vad som ligger bakom motivation till klimataktivism i den radikala klimat- och miljörörelsen Extinction Rebellion (XR), samt klimataktivisters syn på civil olydnad som förändringsmetod. Genom en analys av inhämtat intervjumaterial framträdde ett antal olika motivationsfaktorer som presenteras ocClimate scientists have sounded the alarm for decades, making increasingly frightening predictions about the coming effects of climate change, yet world leaders have largely failed to address the climate change crisis. As the real time effects of climate change are starting to be felt around the world, citizen activists are increasingly taking matters into their own hands, adding pressure on gover

Låna En Forskare 2022

Johan Nordstrand, KTH: A million? More! Two billion? Yes! A proud smile emerges on the face of the student who got the right answer. Then, a heavy atmosphere rapidly descends on the group as they intuitively be- gin to realize what it means. That day, the students gained deeper fundamental insights into the importance of water. That day, I visited as part of an event called ForskarFredag. Läs mer

https://www.hallbarhet.lu.se/sites/hallbarhet.lu.se/files/2022-05/La%CC%8Ana%20en%20forskare%202022.pdf - 2026-06-05

Events & dates

July-August. The Journey Summer SchoolLearn all about climate change science and start-ups over the summer! Join top-graduates on a journey across Europeand some of its best universities and businesses. Get the tools to make an impact on the global effort to find solutions to climate change and become an entrepreneur – in only three, or five weeks. You will undergo a vast development, create busin

https://www.climate-kic.lu.se/events-dates - 2026-06-03

The Sustainable Future of Music Festivals: How can new policy instruments and voluntary guidance tools help music festivals become more sustainable?

Over the last decade the music festival sector grew enormously: in 2008 over a million festivalgoers gathered in the UK to share music and companionship. However in doing so musicfestivals generate large volumes of waste streams and consume large quantities of resources. Amusic festival of more than 40 000 people will produce in the order of 2000 tons of CO2e –with audience transportation and on s

Ecology of parasitoids and their hosts in oilseed rape fields

Oilseed rape fields are a very common crop in the agricultural landscape of southern Sweden, and they can harbour surprisingly many insect species. Some of them are herbivores that feed on various parts of the oilseed rape plant, others are natural enemies of the herbivores, and even more species are tourists from the surrounding landscape. In my thesis I have studied these insects and how their pOilseed rape fields are a very common crop in the agricultural landscape of southern Sweden, and they can harbour surprisingly many insect species. Some of them are herbivores that feed on various parts of the oilseed rape plant, others are natural enemies of the herbivores, and even more species are tourists from the surrounding landscape. In my thesis I have studied these insects and how their p

Winter wheat yield prediction using UAV imagery and machine learning: case studies in Sweden and Morocco

To address global food security challenges caused by population growth and climate change, accurate prediction of crop yield is essential for sustainable agriculture. Winter wheat, a key global crop, faces production instability in regions like Sweden and Morocco due to extreme weather conditions. This study employed unmanned aerial vehicle (UAV)-based multispectral imagery and digital surface mod

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PLUGGJOBB Kvalificerat arbete för akademiker under studietiden Studenter behöver relevanta extrajobb på schyssta villkor under studietiden Kommuner och landsting behöver rekrytera en halv miljon medarbetare inom 10 år SATSA PÅ ETT UTBYTE MED MÅNGA VINNARE Sveriges Kommuner och Landsting / Pacta /AkademikerAlliansen / Vision Akademikerförbundet SSR / Ledarna / Teaterförbundet Sveriges Kommuner och

https://www.saco.se/globalassets/lokala-akademikerforeningar/kommun-och-region/akademikeralliansen/dokument/broschyrer/pluggjobb_kit_fortroendevalda.pdf - 2026-06-05

Grasslands ancient and modern : Soil nutrients, habitat age and their relation to Ellenberg N

Questions: To what extent does the long-term process of grassland succession reflect changes in nutrient availability or other effects of grassland history? Plant communities in ancient, semi-natural pastures include many species associated with nutrient-poor soils. However, semi-natural pasture communities can also develop on previously arable sites — as nutrient levels decline over time. In Euro

Studies of Novel Nanostructures by Cross- sectional Scanning Tunneling Microscopy

This thesis presents structural and morphological studies of semiconductor nanostructures, namely quantum dots, nanowires and a dilute ferromagnetic semiconductor. These nanostructures are investigated on the atomic scale using cross-sectional scanning tunneling microscopy (XSTM). Indium arsenide (InAs) quantum dots in both an indium phosphide (InP) and GaAs matrix are studied. The InAs/InP quantu

Quantitative vegetation reconstruction from pollen analysis and historical inventory data around a Danish small forest hollow

Questions Can the model performance of the landscape reconstruction algorithm (LRA) for small forest hollows be validated through comparison to inventory-based vegetation reconstructions from the last 150yrs? Does the application of LRA and the comparison to historical data enhance interpretation of the pollen record? Location Denmark. The Gribskov-Ostrup small forest hollow (56 degrees N, 12 degr

A2030 monthly Update 250210

Agenda 2030 Graduate School monthly newsletter #2 2025-02-10 Ylva van Meeningen Hi! I know there are a bunch of you who feel quite sick of winter right about now. It is still dark, it is still cold, all the additional lights in people’s windows are gone and it is a loooong way to summer. I am one of those persons who have kind of always liked February in the sense that the small differences actual

https://www.agenda2030graduateschool.lu.se/sites/agenda2030graduateschool.lu.se/files/2025-02/A2030_monthly%20update_250210.pdf - 2026-06-05