Researchers from diverse disciplines, including organismal and cellular physiology, sports science, human nutrition, evolution and ecology, have sought to understand the causes and consequences of the surprising variation in metabolic rate found among and within individual animals of the same species. Research in this area has been hampered by differences in approach, terminology and methodology,

AIMS: Cellular communication network factor 2 (CCN2) is a matricellular protein implicated in fibrotic diseases, with ongoing clinical trials evaluating anti-CCN2-based therapies. By uncovering CCN2 as abundantly expressed in non-diseased artery tissue, this study aimed to investigate the hypothesis that CCN2 plays a pivotal role in maintaining smooth muscle cell (SMC) phenotype and protection aga

INTRODUCTION: The Alzheimer's Association and the Society of Nuclear Medicine and Molecular Imaging convened a multidisciplinary workgroup to update appropriate use criteria (AUC) for amyloid positron emission tomography (PET) and to develop AUC for tau PET. METHODS: The workgroup identified key research questions that guided a systematic literature review on clinical amyloid/tau PET. Building on

Background. Primary glomerular disease (PGD) is a major cause of end-stage kidney disease (ESKD) leading to kidney replacement therapy (KRT). We aimed to describe incidence (trends) in individuals starting KRT for ESKD due to PGD and to examine their survival and causes of death. Methods. We used data from the European Renal Association (ERA) Registry on 69 854 patients who started KRT for ESKD du

– 254 – Utbildningsplan 1 Identifikation • Programmets namn och inriktning: kyrkomusikerutbildning. • Omfattning i högskolepoäng: 180 hp. • Nivå: G. • Programkod: KGKYM. • Utbildningsplanen är beslutad i Konstnärliga fakultetsstyrelsen den 12 juni 2013. Utbild­ ningsplanen träder i kraft den 2 september 2013. 2 Programbeskrivning Högre kyrkomusikerutbildning syftar till att utbilda musiker med god

https://www.mhm.lu.se/en/sites/mhm.lu.se.en/files/utbildnings_utbpl_kandidat_ky1.pdf - 2025-08-08

Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery.

BACKGROUND: Circulating adiponectin and leptin have been associated with risk of pancreatic cancer. However, the relationship between long-term exposure to these adipokines in the prediagnostic period with patient survival has not been investigated.METHODS: Adipokine levels were measured in prospectively collected samples from 472 patients with pancreatic cancer. Because of sex-specific difference

The Alzheimer's Association's Research Roundtable met in November 2017 to explore the new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease. The meeting allowed experts in the field from academia, industry, and government to provide perspectives on the new National Institute on Aging and the Alzheimer's Association Research Framework. This revie

Recombinant adeno-associated viruses (AAVs) are popular in vivo gene transfer vehicles. However, vector doses needed to achieve therapeutic effect are high and some target tissues in the central nervous system remain difficult to transduce. Gene therapy trials using AAV for the treatment of neurological disorders have seldom led to demonstrated clinical efficacy. Important contributing factors are

Genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of childhood acute lymphoblastic leukemia (ALL). To identify new susceptibility loci for the largest subtype of ALL, B-cell precursor ALL (BCP-ALL), we conducted a meta-analysis of two GWASs with imputation using 1000 Genomes and UK10K Project data as reference (totaling 1658 cases an

We conducted pooled and meta-analyses of the association of the calpain-10 gene (CAPN10) polymorphisms SNP-43, Indel-19 and SNP-63 individually and as haplotypes with type 2 diabetes (T2D) in 3237 patients and 2935 controls of European ancestry. In the pooled analyses, the common SNP-43*G allele was associated with modest but statistically significant increased risk of T2D (odds ratio (OR) = 1.11

We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells (Fh1βKO mice) appear normal for 6–8 weeks but then develop progressive glucose intolerance and diabetes. Glucose tolerance is rescued by expression of mitochondrial or cytosolic FH but not by deletion of Hif1α or Nrf2. Progressive hyperglycem

We assessed the association between 1,414 single nucleotide polymorphisms (SNPs) in genes involved in synthesis and metabolism of steroid hormones and insulin-like growth factor 1, and risk of breast cancer in situ (BCIS), with the aim of determining whether any of these were disease specific. This was carried out using 1,062 BCIS cases and 10,126 controls as well as 6,113 invasive breast cancer c

The activated B cell (ABC-like) subtype of diffuse large B cell lymphoma (DLBCL) is characterized by chronic activation of signaling initiated by immunoglobulin m (IgM). By analyzing the DNA copy number profiles of 1000 DLBCL tumors, we identified gains of 18q21.2 as the most frequent genetic alteration in ABC-like DLBCL. Using integrative analysis of matched gene expression profiling data, we fou

Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels by stimulation of hepatic glucose production. This counterregulatory mechanism is impaired in diabetes. Here we show in mice that therapeutic concentrations of insulin inhibit g

Incidence of differentiated thyroid carcinoma (DTC) varies considerably between ethnic groups, with particularly high incidence rates in Pacific Islanders. Here, we conducted a genome-wide association study (GWAS) involving 1,554 cases/1,973 controls of European ancestry and 301 cases/348 controls of Oceanian ancestry from the EPITHYR consortium. Our results confirmed the association with the know

Lunds universitets anmälningsanvisningar 2023-09-05 Dnr STYR 2023/1470 Antagningsnämnden Lunds universitets anmälningsanvisningar Innehåll Lunds universitets anmälningsanvisningar ......................................................................... 1 Så här anmäler du dig .......................................................................................................... 3 När du anmäle

https://www.staff.lu.se/sites/staff.lu.se/files/2023-09/Anm%C3%A4lningsanvisningar%20f%C3%B6r%20l%C3%A4s%C3%A5ret%202024-2025%5B1%5D.pdf - 2025-08-08

Universitetslektor Kontaktinformation E-post: thomas [dot] pugh [at] nateko [dot] lu [dot] se Mobil: +46 46 222 86 97Organisation Institutionen för naturgeografi och ekosystemvetenskap Rumsnummer: 363 Hämtställe: 16 WebbplatsThomas Pughs profil i Lunds universitets forskningsportalAndra roller Forskare MERGE: ModElling the Regional and Global Earth system Profilområdesmedlem LU profilområde: Natur

https://www.nateko.lu.se/sv/thomas-pugh - 2025-08-07

Rapport till UMAS ledning tisdag 14/11 2006 kl 13 TEDDY årsrapport 1 2010-04-23 TEDDY-studien (The Environmental Determinants of Diabetes in the Young) Årsrapport 2009 TEDDY årsrapport 2 2010-04-23 Bakgrund Vi kan inte leva utan insulin. Ett barn som har fått typ 1 diabetes saknar insulin och tvingas således ta dagliga insulininjektioner och göra ständiga blodsockerkontroller under resten av livet

https://www.teddy.lu.se/sites/teddy.lu.se/files/2009_teddy_arsrapport.pdf - 2025-08-08