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Background Postoperative pancreatic fistula (POPF) is a major complication after left pancreatectomy. The current International Study Group of Pancreatic Surgery classification has limitations, including heterogeneity in morbidity and high interobserver variability. This study aimed to assess POPF-related morbidity after left pancreatectomy and propose a refined classification system. Methods Pati

Following regulatory approval of anti-amyloid beta (Aβ) therapies, a better characterization of patients receiving these treatments is needed to guide clinical management and inclusion in future trials. This Alzheimer's Association-convened workgroup proposes a terminology, treatment-related amyloid clearance (TRAC), to reflect alterations in disease pathophysiology based on biomarker evidence for

Hypomethylating agents (HMAs) are frontline therapies for Myelodysplastic Neoplasms (MDS) and Acute Myeloid Leukemia (AML). However, acquired resistance and treatment failure are commonplace. To address this, we perform a genome-wide CRISPR-Cas9 screen in a human MDS-derived cell line, MDS-L, and identify TOPORS as a loss-of-function target that synergizes with HMAs, reducing leukemic burden and i

Swelling of the brain or spinal cord (CNS edema) affects millions of people every year. All potential pharmacological interventions have failed in clinical trials, meaning that symptom management is the only treatment option. The water channel protein aquaporin-4 (AQP4) is expressed in astrocytes and mediates water flux across the blood-brain and blood-spinal cord barriers. Here we show that AQP4

Allergic immunity is orchestrated by group 2 innate lymphoid cells (ILC2s) and type 2 helper T (Th2) cells prominently arrayed at epithelial- and microbial-rich barriers. However, ILC2s and Th2 cells are also present in fibroblast-rich niches within the adventitial layer of larger vessels and similar boundary structures in sterile deep tissues, and it remains unclear whether they undergo dynamic r

Aims/hypothesis: The aim of this work was to examine the impact of hypoglycaemia on daily functioning among adults with type 1 diabetes or insulin-treated type 2 diabetes, using the novel Hypo-METRICS app. Methods: For 70 consecutive days, 594 adults (type 1 diabetes, n=274; type 2 diabetes, n=320) completed brief morning and evening Hypo-METRICS ‘check-ins’ about their experienced hypoglycaemia a

Introduction: Reporting of hypoglycaemia and its impact in clinical studies is often retrospective and subject to recall bias. We developed the Hypo-METRICS app to measure the daily physical, psychological, and social impact of hypoglycaemia in adults with type 1 and insulin-treated type 2 diabetes in real-time using ecological momentary assessment (EMA). To help assess its utility, we aimed to de

Maturity-onset diabetes of the young (MODY) is a heterogeneous single gene disorder characterized by non–insulin-dependent diabetes, an early onset and autosomal dominant inheritance. Mutations in six genes have been shown to cause MODY. Approximately 15–20% of families fitting MODY criteria do not have mutations in any of the known genes. These families provide a rich resource for the identificat

Background Although human leukocyte antigen (HLA) DQ and DR loci appear to confer the strongest genetic risk for type 1 diabetes, more detailed information is required for other loci within the HLA region to understand causality and stratify additional risk factors. The Type 1 Diabetes Genetics Consortium (T1DGC) study design included high-resolution genotyping of HLA-A, B, C, DRB1, DQ, and DP loc

BACKGROUND Nivolumab was associated with higher rates of objective response than chemotherapy in a phase 3 study involving patients with ipilimumab-refractory metastatic melanoma. The use of nivolumab in previously untreated patients with advanced melanoma has not been tested in a phase 3 controlled study. METHODS We randomly assigned 418 previously untreated patients who had metastatic melanoma w

The intronic SNP rs7903146 in the T-cell factor 7-like 2 gene (TCF7L2) is the common genetic variant most highly associated with Type 2 diabetes known to date. The risk T-allele is located in an open chromatin region specific to human pancreatic islets of Langerhans, thereby accessible for binding of regulatory proteins. The risk T-allele locus exhibits stronger enhancer activity compared to the n

Acute myeloid leukemia with t(6; 9)(p22; q34) is listed as a distinct entity in the 2008 World Health Organization classification, but little is known about the clinical implications of t(6; 9)-positive myeloid leukemia in children. This international multicenter study presents the clinical and genetic characteristics of 62 pediatric patients with t(6; 9)/DEKNUP214-rearranged myeloid leukemia; 54

Anemia because of insufficient production of and/or response to erythropoietin (Epo) is a major complication of chronic kidney disease and cancer. The mechanisms modulating the sensitivity of erythroblasts to Epo remain poorly understood. We show that, when cultured with Epo at suboptimal concentrations, the growth and clonogenic potential of erythroblasts was rescued by transferrin receptor 1 (Tf

Research in the Area of Clouds, Aerosols and Climate The research group of Phillips is tackling a range of issues, such as ice initiation in clouds, effects on precipitation from bio-aerosols, and development of new technologies for representing clouds in global climate models. Contact details Email: vaughan [dot] phillips [at] mgeo [dot] lu [dot] seOrganisation Department of Earth and Environment

https://www.nateko.lu.se/vaughan-phillips - 2026-06-04

The essay examines the application of Section 33 of the Contracts Act (SFS 1915:218), with particular focus on the Supreme Court’s (HD) ruling in the case ‘Nätkasinot’ (T 607-24, 1 July 2025). Section 33, which addresses good faith and honour, has rarely been applied by the courts but has recently gained renewed relevance through the ‘Nätkasinot’ judgment. The purpose of the essay is to analyse th

Popular Abstract in Swedish Jag kommer i denna avhandling att resonera kring frågor om skräckfilm som genre och studera hur Hellraiser förhåller sig till dess teman och problem. Hellraiser är en skräckfilm och således, på gott och ont, bunden till en kontroversiell genre. Jag anser det omöjligt att frångå detta i min analys där jag bland annat studerar ondska, sexualitet och genus. Efter en presenIn this dissertation I will discuss horror film as a genre and study how Hellraiser relates to its themes and problems. First I describe the production of the film and after that I present Clive Barker - his background, authorship, film-making and artwork. Next I study the problems of the genre and the different ways in which this genre is defined. I look at narrative characteristics as well as, f

The offence rape is a phenomenon in Swedish criminal law that engages many people and often creates vivid reactions when media reports about verdicts of acquittal in cases involving rape. The rape section has been changed at multiple times over the years. The last change entered into force July 1, 2013 when the new concept ”particularly vulnerable situation” (”särskilt utsatt situation”) replaced

Sustainability reporting has emerged as a common practice of 21st-century business. A sustainability report is a report published by an organization that presents the economic, environmental and social impacts caused by its activities. The Global Reporting Initiative (GRI) is a non-profit organization with the mission to promote the transition to a sustainable global economy by providing a framewo

Penningtvätt utgör ett problem för samhällsekonomin, då det innebär ett hot mot det finansiella systemet om pengar med kriminellt ursprung hamnar i den legala ekonomin. Sveriges skydd för att kriminella tillgångar tvättas i den legala ekonomin har visat sig ineffektivt. Financial Action Task Force on money laundering har påpekat bristerna i svensk rätt och rekommenderat åtgärder då det inte finns If money with illicit origins enters into circulation in the financial system it poses a threat to the mechanisms of the financial system. Financial Action Task Force have concluded that the Swedish legal requirements for combating money laundering is insufficient, and the organisation have advised Swedish authorities to effectuate preventive measures. Therefore, the Swedish legal system is not co

Ger pressar dig bra vibrationer? Idag är allt från kaffemaskiner och gräsklippare till krutpistoler och bilar uppkopplade och kan närsom-helst ge oss en statusrapport genom bara ett par klick i en app. Vi kan med mobilen kolla bilens bräns-lenivå, geografiska position eller om vi glömt att låsa på väg in från par-keringen. Så varför skulle inte statu-sen på utrustningen som används för att tillveIn a world where the concept of just-in-time has been lifted outside of the manu-facturing world and onto the market, the increasing demand of luxury wares like cars is accompanied only by tougher industrial conditions and no room for error. Loss of productivity and decrease in efficiency can be devastating to any manufac-turing company in today’s market climate. One of the largest causes of these