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Background and aim: Vitamin K has been proposed to have a preventive effect against arterial calcification through activation of the vitamin K dependent proteins and potentially protect against progression of atherosclerosis. Our aim was to assess the association between vitamin K status and vascular health in a general elderly population. Methods and results: In a cross-sectional study, the vitam
Fluid biomarkers are revolutionizing the diagnosis and management of neurodegenerative diseases by enabling earlier diagnosis and disease monitoring. In particular, blood-based biomarkers have emerged as a minimally invasive and scalable alternative to cerebrospinal fluid analysis. Recent advances in blood-based tau biomarkers have shown high diagnostic accuracy for Alzheimer’s disease (AD). Other
Hypomethylating agents (HMAs) are frontline therapies for Myelodysplastic Neoplasms (MDS) and Acute Myeloid Leukemia (AML). However, acquired resistance and treatment failure are commonplace. To address this, we perform a genome-wide CRISPR-Cas9 screen in a human MDS-derived cell line, MDS-L, and identify TOPORS as a loss-of-function target that synergizes with HMAs, reducing leukemic burden and i
Background Although human leukocyte antigen (HLA) DQ and DR loci appear to confer the strongest genetic risk for type 1 diabetes, more detailed information is required for other loci within the HLA region to understand causality and stratify additional risk factors. The Type 1 Diabetes Genetics Consortium (T1DGC) study design included high-resolution genotyping of HLA-A, B, C, DRB1, DQ, and DP loc
The quantification and characterization of circulating immune cells provide key indicators of human health and disease. To identify the relative effects of environmental and genetic factors on variation in the parameters of innate and adaptive immune cells in homeostatic conditions, we combined standardized flow cytometry of blood leukocytes and genome-wide DNA genotyping of 1,000 healthy, unrelat
The Sardinian dhole (Cynotherium sardous) was an iconic and unique canid species that was endemic to Sardinia and Corsica until it became extinct at the end of the Late Pleistocene. Given its peculiar dental morphology, small body size, and high level of endemism, several extant canids have been proposed as possible relatives of the Sardinian dhole, including the Asian dhole and African hunting doThe Sardinian dhole (Cynotherium sardous)1 was an iconic and unique canid species that was endemic to Sardinia and Corsica until it became extinct at the end of the Late Pleistocene.2-5 Given its peculiar dental morphology, small body size, and high level of endemism, several extant canids have been proposed as possible relatives of the Sardinian dhole, including the Asian dhole and African huntin
PURPOSE: The first interim analysis of the phase III, randomized, placebo-controlled TITAN study showed that apalutamide significantly improved overall survival (OS) and radiographic progression-free survival in patients with metastatic castration-sensitive prostate cancer (mCSPC) receiving ongoing androgen deprivation therapy (ADT). Herein, we report final efficacy and safety results after unblin
The SCHOLAR-2 retrospective study highlighted poor overall survival (OS) with standard of care (SOC) regimens among patients with relapsed/refractory (R/R) mantle cell lymphoma (MCL) who failed a covalent Bruton tyrosine kinase inhibitor (BTKi). In the ZUMA-2 single-arm trial, brexucabtagene autoleucel (brexu-cel; autologous anti-CD19 CAR T-cell therapy) demonstrated high rates of durable response
Maturity-onset diabetes of the young (MODY) is a heterogeneous single gene disorder characterized by non–insulin-dependent diabetes, an early onset and autosomal dominant inheritance. Mutations in six genes have been shown to cause MODY. Approximately 15–20% of families fitting MODY criteria do not have mutations in any of the known genes. These families provide a rich resource for the identificat
The intronic SNP rs7903146 in the T-cell factor 7-like 2 gene (TCF7L2) is the common genetic variant most highly associated with Type 2 diabetes known to date. The risk T-allele is located in an open chromatin region specific to human pancreatic islets of Langerhans, thereby accessible for binding of regulatory proteins. The risk T-allele locus exhibits stronger enhancer activity compared to the n
OBJECTIVE: In a multicenter cohort of probable dementia with Lewy bodies (DLB), we tested the hypothesis that β-amyloid and tau biomarker positivity increases with age, which is modified by APOE genotype and sex, and that there are isolated and synergistic associations with the clinical phenotype. METHODS: We included 417 patients with DLB (age 45-93 years, 31% women). Positivity on β-amyloid (A+)
Accurate diagnosis of rare inherited anaemias is challenging, requiring a series of complex and expensive laboratory tests. Targeted next-generation-sequencing (NGS) has been used to investigate these disorders, but the selection of genes on individual panels has been narrow and the validation strategies used have fallen short of the standards required for clinical use. Clinical-grade validation o
Föreläsning på UR: Elevens roll i skolan i ett historiskt perspektiv Föreläsning på UR: Elevens roll i skolan i ett historiskt perspektiv Av Caroline Cabot - Publicerad den 15 maj 2024 Mona Holmqvist, professor på institutionen för utbildningsvetenskap vid Lunds universitet. Foto: UR Vilka grupper av elever gynnas eller missgynnas av det rådande skolsystemet? Och hur har elevens roll i skolan förä
https://www.uvet.lu.se/article/foerelaesning-elevens-roll-i-skolan-i-ett-historiskt-perspektiv-1/ - 2026-09-20
Senior lecturer Contact details Email: thomas [dot] pugh [at] mgeo [dot] lu [dot] se Mobile: +46 46 222 86 97Organisation Department of Earth and Environmental Sciences (MGeo) Room number: 363 Service point: 16 WebpageThomas Pughs profile in Lund University research portalOther affiliations Member of Strategic Research Area BECC: Biodiversity and Ecosystem services in a Changing Climate Profile ar
https://www.nateko.lu.se/thomas-pugh - 2026-10-13
Senior lecturer Contact details Email: thomas [dot] pugh [at] mgeo [dot] lu [dot] se Mobile: +46 46 222 86 97Organisation Department of Earth and Environmental Sciences (MGeo) Room number: 363 Service point: 16 WebpageThomas Pughs profile in Lund University research portalOther affiliations Member of Strategic Research Area BECC: Biodiversity and Ecosystem services in a Changing Climate Profile ar
https://www.mgeo.lu.se/en/thomas-pugh - 2026-10-13
Till följd av finanskrisen förlorade konsumenter genom placeringar i riskfyllda finansiella instrument stora delar av sina investeringar. Under åren 2008 och 2009 inkom fler klagomål till Finansinspektionen och Konsumentverket jämfört med tidigare år om att många konsumenter via rådgivning rekommenderats produkter som inte motsvarat den risk de varit beredda att ta eller att information om risken The aftermath of the financial crisis meant that many consumers lost parts of their investments because they had invested their savings in risky financial instruments. Between the years of 2008 and 2009, the Swedish Financial Supervisory Authority, Finansinspektionen, and the Swedish Consumer Agency, Konsumentverket, received more complaints, compared to previous years, regarding financial advisor
Syftet med denna uppsats är att utreda rättsläget för barn som häktas och därefter diskutera hur det förhåller sig till barns särskilda skyddsvärde i straff- och straffprocessrätten. Jag diskuterar och reflekterar även över lagstiftningens eventuella brister, behov av förändring och förbättring samt hur förändringar och förbättringar i sådana fall skulle kunna te sig lämpliga utifrån ett barnrättsThe purpose of this thesis is to investigate the legal position for children being detained and discussing how that relates to children’s particular protective value in penalty- and criminal procedure law. I am also discussing and reflecting on the legislation’s eventual flaws, need of change and improvement and how changes and improvements in those cases could be appropriate from a perspective of
On the July 1, 2020, a new framework of rules regarding reportable arrangements was introduced in Sweden and at the same time a reporting obligation to give information about reportable arrangements to the Swedish Tax Agency (STA) was introduced. For an arrangement to be reportable it must be cross-border and include at least one hallmark. A hallmark is a characteristic in an arrangement which is
Att Söka efter Higgs-Bosonen Den dittills oupptäckta Higgs-bosonen upptäcktes förra året på CERN i Schweiz. Denna partikel har en central roll i partikelfysiken, och var därför oerhört viktig att upptäcka. Då den lever väldigt kort tid går den inte att detektera direkt. Detta arbete söker finna massan hos Higgs-bosonen, och använder sig då av fallet då den sönderfaller till fyra myoner. Higgs-bosoAbstract Within the Standard Model of particle physics, there was only one undiscovered fundamental particle. This was the Higgs boson. In July 2012, the announcement was made that a Higgs like particle had been discovered by the ATLAS Collaboration and the CMS Collaboration at CERN. The aim of this Bachelor’s thesis was to use data collected by the ATLAS detector facility to estimate the mass of
Syftet med den här uppsatsen är att ur ett civilrättsligt perspektiv undersöka hur de svenska civilrättsliga reglerna skyddar någon som riskerar att utsättas för barn- och tvångsäktenskap, samt olika myndigheters agerande och förhållningssätt när de möter någon som befinner sig i riskzonen för påtvingade äktenskap. En stor del av de äktenskap som ingås mot någons vilja berör parter som bor i oli
