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miRNA och dess termodynamik I alla männskliga celler (förutom i de röda blodkropparna) finns en cellkärna. Inuti kärnan finns DNA:t. Segment av DNA kan läsas i en process kallad för transkription. I denna process omkodas det cellulära DNA genom transkription till den strukturellt liknande molekylen RNA. Denna molekyl blir vanligtvis avläst av cellen i en process kallad translation där kedjor av aAbstract We have performed a series of experiments in order to elucidate the properties of two breast cancer related microRNAs, here we denote A and B. In one experiment, we tested varying concentrations of biologically relevant cation upon the melting curve of A. We saw that the monovalent conditions favoured a melting curve that had two inflexion points whereas the divalent conditions favoured

Shoreline protection law and the right of commons are unique from a global perspective. The purpose of the shoreline protection law is to promote and maintain a good habitat for plants and animals and to secure the basis for the public's access to the coastline. On the 1st of July 2009 the new and changed shoreline protection law took effect. The main purpose of the change was to promote rura

Klimatförändringar har under de senaste åren blivit alltmer akuta. Runt om i världen förekommer naturkatastrofer på grund av den globala uppvärmningen och den globala medeltemperaturen ligger långt över målsättningen om 1,5°C. För att en förändring ska kunna genomföras krävs det att världen, enskilda länder, företag och individer vidtar åtgärder. Till följd av klimatkrisen har Förenta nationerna oClimate change has become increasingly urgent in recent years. Around the world, natural disasters are occurring due to global warming and the global average temperature is well above the 1.5°C target. In order to achieve chang-es, the world, countries, companies, and individuals need to take action. In response to the climate crisis, the United Nations and the EU have developed international agre

I Sverige lever över 200 000 barn i hem där det förekommer våld. FN:s kon-vention om barnets rättigheter påpekade i ett slutbetänkande att barn som be-vittnar våld kan lida lika mycket skada som de barn som är direkt utsatta för våldet. Forskning visar att det kan vara mer skadligt för ett barn att uppleva våld än att utsättas för det själv. Implementeringen av barnkonventionen var en bidragande fOver 200 000 children in Sweden live in homes where violence is occurring. In a report from the UN convention on the Rights of the Child, it was pointed out that children who witness violence can suffer as much harm as those chil-dren who are directly exposed to it. Research shows that it can be more harm-ful for a child to experience violence than to be exposed to it themselves. The implementatio

Europeiska unionens kommande utmaning av att möta och bekämpa klimatförändringar har resulterat i att frågan om vilka förutsättningar som finns för att beakta hållbarhetsaspekter inom ramen för tillämpningen av unionens konkurrensregler hamnat alltmer i fokus. Den 1 juni 2023 antog Europeiska kommissionen reviderade riktlinjer för tillämpningen av artikel 101 i fördraget om Europeiska unionens funThe European Union’s upcoming challenge in addressing and combating climate change has brought the question of under which conditions sustainability aspects can be considered in the application of the Union’s competition rules increasingly into focus. On June 1, 2023, the European Commission adopted revised Guidelines on the applicability of Article 101 of the Treaty on the Functioning of the Euro

No. 1 2019 M O D E V E T E N S K A P Vid Lunds Universitet H Ä L S N I N G F R Å N S T UD I E R Å D E T Modevetare, mitt i julledigheten vill vi rikta ett stort tack till er för en lyckad julsittning! Vi hade en väldigt trevlig kväll och hoppas att ni hade lika roligt som oss. Under hösten har studierådet drivit ett case som handlar om att integrera modevetenskapen med övriga utbildningar på campu

https://www.kultur.lu.se/fileadmin/user_upload/kultur/Utbildning/Mode_maanadsbrev/Ma__nadsbrev_januari_2019.pdf - 2025-11-20

Pancreatic islets are complex micro-organs consisting of at least three different cell types: glucagon-secreting alpha, insulin-producing beta and somatostatin-releasing delta cells. Somatostatin is a powerful paracrine inhibitor of insulin and glucagon secretion. In diabetes, increased somatostatinergic signalling leads to defective counter-regulatory glucagon secretion. This increases the risk o

Purpose: To compare rates of tau biomarker positivity (T-status) per the 2018 Alzheimer’s Disease (AD) Research Framework derived from [18F]flortaucipir (FTP) PET visual assessment, FTP quantification, and cerebrospinal fluid (CSF) phosphorylated Tau-181 (PTau181). Methods: We included 351 subjects with varying clinical diagnoses from three cohorts with available FTP PET and CSF PTau181 within 18

Introduction: Reporting of hypoglycaemia and its impact in clinical studies is often retrospective and subject to recall bias. We developed the Hypo-METRICS app to measure the daily physical, psychological, and social impact of hypoglycaemia in adults with type 1 and insulin-treated type 2 diabetes in real-time using ecological momentary assessment (EMA). To help assess its utility, we aimed to de

Anemia because of insufficient production of and/or response to erythropoietin (Epo) is a major complication of chronic kidney disease and cancer. The mechanisms modulating the sensitivity of erythroblasts to Epo remain poorly understood. We show that, when cultured with Epo at suboptimal concentrations, the growth and clonogenic potential of erythroblasts was rescued by transferrin receptor 1 (Tf

Maturity-onset diabetes of the young (MODY) is a heterogeneous single gene disorder characterized by non–insulin-dependent diabetes, an early onset and autosomal dominant inheritance. Mutations in six genes have been shown to cause MODY. Approximately 15–20% of families fitting MODY criteria do not have mutations in any of the known genes. These families provide a rich resource for the identificat

Background Although human leukocyte antigen (HLA) DQ and DR loci appear to confer the strongest genetic risk for type 1 diabetes, more detailed information is required for other loci within the HLA region to understand causality and stratify additional risk factors. The Type 1 Diabetes Genetics Consortium (T1DGC) study design included high-resolution genotyping of HLA-A, B, C, DRB1, DQ, and DP loc

Acute myeloid leukemia with t(6; 9)(p22; q34) is listed as a distinct entity in the 2008 World Health Organization classification, but little is known about the clinical implications of t(6; 9)-positive myeloid leukemia in children. This international multicenter study presents the clinical and genetic characteristics of 62 pediatric patients with t(6; 9)/DEKNUP214-rearranged myeloid leukemia; 54

BACKGROUND Nivolumab was associated with higher rates of objective response than chemotherapy in a phase 3 study involving patients with ipilimumab-refractory metastatic melanoma. The use of nivolumab in previously untreated patients with advanced melanoma has not been tested in a phase 3 controlled study. METHODS We randomly assigned 418 previously untreated patients who had metastatic melanoma w

Allergic immunity is orchestrated by group 2 innate lymphoid cells (ILC2s) and type 2 helper T (Th2) cells prominently arrayed at epithelial- and microbial-rich barriers. However, ILC2s and Th2 cells are also present in fibroblast-rich niches within the adventitial layer of larger vessels and similar boundary structures in sterile deep tissues, and it remains unclear whether they undergo dynamic r

Hypomethylating agents (HMAs) are frontline therapies for Myelodysplastic Neoplasms (MDS) and Acute Myeloid Leukemia (AML). However, acquired resistance and treatment failure are commonplace. To address this, we perform a genome-wide CRISPR-Cas9 screen in a human MDS-derived cell line, MDS-L, and identify TOPORS as a loss-of-function target that synergizes with HMAs, reducing leukemic burden and i

Aims/hypothesis: The aim of this work was to examine the impact of hypoglycaemia on daily functioning among adults with type 1 diabetes or insulin-treated type 2 diabetes, using the novel Hypo-METRICS app. Methods: For 70 consecutive days, 594 adults (type 1 diabetes, n=274; type 2 diabetes, n=320) completed brief morning and evening Hypo-METRICS ‘check-ins’ about their experienced hypoglycaemia a

The intronic SNP rs7903146 in the T-cell factor 7-like 2 gene (TCF7L2) is the common genetic variant most highly associated with Type 2 diabetes known to date. The risk T-allele is located in an open chromatin region specific to human pancreatic islets of Langerhans, thereby accessible for binding of regulatory proteins. The risk T-allele locus exhibits stronger enhancer activity compared to the n

Swelling of the brain or spinal cord (CNS edema) affects millions of people every year. All potential pharmacological interventions have failed in clinical trials, meaning that symptom management is the only treatment option. The water channel protein aquaporin-4 (AQP4) is expressed in astrocytes and mediates water flux across the blood-brain and blood-spinal cord barriers. Here we show that AQP4

Background: Neoadjuvant therapy is protective of postoperative pancreatic fistula in pancreatoduodenectomy. However, the effect of neoadjuvant therapy after left pancreatectomy remains unclear. The aim of this international multicenter study was to evaluate the impact of neoadjuvant therapy on short term outcomes after left pancreatectomy for pancreatic ductal adenocarcinoma. Methods: Patients und