Sökresultat

Neuroblastoma is a childhood solid tumour originating from undifferentiated neural progenitor cells of the sympathetic nervous system. Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. In the present study, we aimed to identify novel drugs that can inhibit the growth and survival of chemoresistant neuroblastoma. High-throughput screening identified a small molecule,

Epidermolysis bullosa simplex (EBS) is usually inherited as an autosomal dominant disease due to monoallelic gain-of-function mutations in KRT5 or KRT14. Although autosomal recessive forms of EBS have been associated with mutations in at least 10 genes, recessive EBS due to homozygous biallelic KRT5 mutations has not been reported previously; it has been hypothesized that it would result in prenat

Background: Dialectical behavior therapy (DBT) is an evidence-based treatment for self-harm and emotion regulation difficulties. A modified version, DBT-Skills System (DBT-SS), has been developed in the USA for individuals with cognitive difficulties. The present study is a pilot study, testing the DBT-SS in a Swedish context.Methods: Six participants were treated with individual therapy and group

Spermine oxidase (SMOX) catalyzes the oxidation of spermine to spermidine. Observational studies have reported SMOX as a source of reactive oxygen species associated with cancer, implying that inhibition of SMOX could be a target for chemoprevention. Here we test causality of SMOX levels with cancer risk using a Mendelian randomization analysis. We performed a GWAS of spermidine/spermine ratio to

Copper (Cu) is one of the most abundant trace metals in all organisms, involved in a plethora of cellular processes. Yet elevated concentrations of the element are harmful, and interestingly prokaryotes are more sensitive for environmental Cu stress than humans. Various transport systems are present to maintain intracellular Cu homeostasis, including the prokaryotic plasmid-encoded multiprotein pc

ClC-1 protein channels facilitate rapid passage of chloride ions across cellular membranes, thereby orchestrating skeletal muscle excitability. Malfunction of ClC-1 is associated with myotonia congenita, a disease impairing muscle relaxation. Here, we present the cryo-electron microscopy (cryo-EM) structure of human ClC-1, uncovering an architecture reminiscent of that of bovine ClC-K and CLC tran

Epidemiological studies show that modifiable risk factors account for approximately 40% of the population variability in risk of developing dementia, including sporadic Alzheimer's disease (AD). Recent findings suggest that these factors may also modify disease trajectories of people with autosomal-dominant AD. With positron emission tomography imaging, it is now possible to study the disease many

Antibody radionuclide conjugates are an emerging modality for targeted imaging and potent therapy of disseminated disease. Coupling of radionuclides to monoclonal antibodies (mAbs) is typically achieved by applying non-site-specific labelling techniques. With the ambition of reducing variability, increasing labelling efficacy and stability, several site-specific conjugation strategies have been de

Terminstider läsåret 2023/24 Beslut Sida 1 av 3 Student och utbildning Diarienummer U 2022/287 2022-06-20 Reviderad: 2022-12-01 Terminstider läsåret 2023/24 För läsåret 2023/24 gäller följande terminstider: Höstterminen 2023 pågår från och med måndagen den 28 augusti 2023 till och med söndagen den 14 januari 2024. Vårterminen 2024 pågår från och med måndagen 15 januari 2024 till och med söndagen d

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2022-12/Terminstider-lasaret-2023-24.pdf - 2026-04-22

https://www.sol.lu.se/media/utbildning/dokument/kurser/LIVA04/20222/LIVA04.4_Schema_HT22_1.pdf - 2026-04-20

Title Still on sale? – A study on the theories about the abnormal return of IPO:s Seminar date: 12/1 2017 Course: FEKH89, Corporate Finance Degree Project, Undergraduate level, Business Administration, 15 ECTS Authors: Julia Borrebaeck, Viktor Lloyd, Jesper Vamborg, Advisor/s: Tore Eriksson Key words: IPO:s, Nasdaq OMX Stockholm, underpricing, long term underperformance, comparative research Purpo

Engelsk sammanfattning Due to the entry into force for a decriminalization regarding homosexuality in July 1944, homosexual activities were not considered as something criminal anymore. The struggle towards a more equal society did not end there. It took until 1979 before homosexuality was removed from the National Board of Health and Welfare (Socialstyrelsens) register of illnesses. Today, homos

On July the 20th 2017 the Swedish government announced a proposition about new rules regarding the taxation of companies. The proposition contained a general interest deduction limitation rule. At the same time, the government proposed that the interest deduction limitation rules in force at the time of writing should be kept with some changes. The purpose of this study is to examine which possibi

Letting a child witness certain criminal acts being committed between relatives to the child has been criminalized since July 1, 2021. The witnessing requirement constitutes a necessary prerequisite for criminal liability and implies that the child must have seen or heard the criminal act being committed. During the legislative process, it was noted that the requirement could give rise to certain

Den svenska straffrätten har under det senaste århundradet genomgått en mängd förändringar. Allt som oftast har påföljdssystemet varit utformad efter de för tillfället förhärskande bestraffningsteorierna. Det finns en lång tradition av särbehandling av unga lagöverträdare i Sverige och till viss del så tas hänsyn till andra intressen när det gäller ungdomar. Denna framställning ska besvara frågornSwedish penal law has undergone many changes over the last centuries. The sanction system has most often been modelled on penalization theories dominant at the time. Sweden has a long tradition of special treatment of young offenders, and other interest are to some extent taken into consideration when it comes to juvenile offenders compared to adults. This essay will answer the questions of which

Många groddjur har minskande populationstrender både lokalt och globalt. Inventeringar av groddjur är en viktig del av arbetet för att få mer information om deras utbredning för att kunna skydda groddjuren och deras miljöer. Detta kan ha positiva effekter även på andra djur och växter eftersom groddjur är bra indikatorer på rika miljöer. Genom sitt vattenupptag via huden är groddjuren extremt käns

The purpose of this thesis is to examine negligent rape in chapter 6 section 1 of the Swedish Criminal Code (brottsbalken, SFS 1962:700) from a legal security perspective. First by examining how the legislator described the requirement in the legislative history and in the text of the law, thereafter by examine how the law has been applied in practice. The new crime of negligent rape was institut

Den 7 oktober 2020 presenterades utredningen Ett särskilt hedersbrott, SOU 2020:57, med förslaget att låta brott med hedersmotiv utgöra en egen brottsrubricering. För att utreda om det vore befogat att införa lagförslaget i brottsbalken analyseras det utifrån några utvalda principer och teorier för kriminalisering. Trots att heder är ett problematiskt och svårdefinierat begrepp kan några karaktäOn October 7, 2020 the investigation Ett särskilt hedersbrott, SOU 2020:57, was presented, with a proposal to let crimes with honor motives constitute a specific criminal provision. In order to investigate if it would be justified to introduce in the Penal Code, the proposal will be analyzed on the basis of some selected principles and theories for criminalization. Although honor is a problemati