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Dysfunctional microRNA (miRNA) networks contribute to inappropriate responses following pathological stress and are the underlying cause of several disease conditions. In pancreatic beta cells, miRNAs have been largely unstudied and little is known about how specific miRNAs regulate glucose-stimulated insulin secretion (GSIS) or impact the adaptation of beta cell function to metabolic stress. In t
OBJECTIVE-We report here genotyping data and type 1 diabetes association analyses for HLA class I loci (A, B, and C) on 1,753 multiplex pedigrees from the Type 1 Diabetes Genetics Consortium (T1DGC), a large international collaborative study. RESEARCH DESIGN AND METHODS-Complete eight-locus HLA genotyping data were generated. Expected patient class I (HLA-A, -B, and -C) allele frequencies were cal
Background-Myocardial scarring from infarction or nonischemic fibrosis forms arrhythmogenic substrate. The Selvester QRS score has been extensively validated for estimating myocardial infarction scar size in the absence of ECG confounders. but has not been tested to quantify scar in patients with hypertrophy, bundle branch/fascicular blocks, or nonischemic cardiomyopathy. We assessed the hypothese
The transcription factor Sox4 has been proposed to underlie the increased type 2 diabetes risk linked to an intronic single nucleotide polymorphism in CDKAL1. In a mouse model expressing a mutant form of Sox4, glucose-induced insulin secretion is reduced by 40% despite normal intracellular Ca2+ signaling and depolarization-evoked exocytosis. This paradox is explained by a fourfold increase in kiss
Obesity is a major threat to global health and metabolically associated with glycerol homeostasis. Here we demonstrate that in human adipocytes, the decreased pH observed during lipolysis (fat burning) correlates with increased glycerol release and stimulation of aquaglyceroporin AQP10. The crystal structure of human AQP10 determined at 2.3 Å resolution unveils the molecular basis for pH modulatio
Diabetes is a bihormonal disorder resulting from combined insulin and glucagon secretion defects. Mice lacking fumarase (Fh1) in their β cells (Fh1βKO mice) develop progressive hyperglycemia and dysregulated glucagon secretion similar to that seen in diabetic patients (too much at high glucose and too little at low glucose). The glucagon secretion defects are corrected by low concentrations of tol
Background: Dialectical behavior therapy (DBT) is an evidence-based treatment for self-harm and emotion regulation difficulties. A modified version, DBT-Skills System (DBT-SS), has been developed in the USA for individuals with cognitive difficulties. The present study is a pilot study, testing the DBT-SS in a Swedish context.Methods: Six participants were treated with individual therapy and group
Copper (Cu) is one of the most abundant trace metals in all organisms, involved in a plethora of cellular processes. Yet elevated concentrations of the element are harmful, and interestingly prokaryotes are more sensitive for environmental Cu stress than humans. Various transport systems are present to maintain intracellular Cu homeostasis, including the prokaryotic plasmid-encoded multiprotein pc
Epidemiological studies show that modifiable risk factors account for approximately 40% of the population variability in risk of developing dementia, including sporadic Alzheimer's disease (AD). Recent findings suggest that these factors may also modify disease trajectories of people with autosomal-dominant AD. With positron emission tomography imaging, it is now possible to study the disease many
This systematic literature review investigates the relationship between air pollution exposure and inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC). Despite the growing concern over air pollution's impact on various health outcomes, studies specifically addressing effects on the digestive system, particularly IBD, are relatively rare. This review aims
Informationspraktikanter till Bolivia, Nicaragua och Peru Är du intresserad av mänskliga rättigheter, demokrati och utvecklingsfrågor? Är du intresserad av Latinamerika? Kan du spanska? Tycker du om att skriva, fotografera eller filma? Sök plats som informationspraktikant för Svalorna Latinamerika i Bolivia, Nicaragua eller Peru! Praktiken Som informationspraktikant för Svalorna Latinamerika (LA)
https://www.keg.lu.se/sites/keg.lu.se/files/informationspraktikanter_vt_2016.pdf - 2026-08-01
Utseende av behöriga för mottagande och uppföljning av rapporter om missförhållanden Sida 1 av 4 BESLUT Diarienummer STYR 2022/1157 Datum 2022-06-16 Rektor Postadress Box 117, 221 00 Lund Besöksadress Sandgatan 5, Lund Telefon 046-222 47 86, 046-222 00 00 E-post kristine.widlund@hr.lu.se Webbadress www.lu.se Utseende av behöriga för mottagande och uppföljning av rapporter om missförhållanden m.m.
2022 Esri Young Scholar Award Esri Sverige presenterar stolt årets omgång av Esri Young Scholar Award. Tävlingen är öppen för alla studenter som är inskrivna på något av Sveriges Universitet och högskolor! “Esri constantly works to develop the next generation of GIS leaders. The Young Scholars Award program allows Esri, our international distributors, and the international education team to recogn
https://www.nateko.lu.se/sites/nateko.lu.se/files/2022-02/2022%20Esri%20Young%20Scholar%20Award.pdf - 2026-08-01
Nya managementpraktiker för en ny socio-materialitet av avfall Att frikoppla avfallsproduktion från ekonomisk tillväxt är nödvändigt för att uppnå en hållbar samhällsutveckling. En sådan frikoppling på samhällsnivå förutsätter en frikoppling på företagsnivå. Syftet med projektet Frikopplingstjänster är att förklara hur avfallsbolag kan utvecklar tjänster som hjälper industriella och kommersiella f
https://www.ses.lu.se/frikopplingstjanster - 2026-07-31
In the Swedish legal system there is limited responsibility for failure to hinder other people´s criminal acts. As of July 1st of 2016 there is a new paragraph in the 6th section of the 23rd chapter of the Swedish Penal Code. It was introduced in order to be able to keep leaders of organized crime responsible for the crimes that are, with them knowing, taking place within the organization. During
On July 1st 2018 the Swedish legislation concerning rape was changed. The line between legal sexual intercourse and illegal sexual assault was moved from coercion to voluntariness. The debate prior to the amendment of the law has partly concerned how the legal process in the courts would be affected by this change. It has been pointed out that there will be difficulties regarding evidence and that
Sammanfattning Debatten om påverkan av masskultur är en debatt som vägrar att dö. Samtalet har cirklat kring allt från hur läsandet av dålig litteratur skulle leda till sämre läsförståelse, till 70-80 talets videovålds-debatt. Idag fokuserar detta samtal på tv- och datorspels påverkan på spelarna. Vi har intresserat oss för vad det är som idag sägs bakom de omedelbara argumenten i detta samtal. I
On the 18th of July 2019, the government appointed an inquiry to evaluate whether or not honour crime should be appointed as a classification of a crime in the penal code. The appointed inquiry was named SOU 2020:57 Ett särskilt hedersbrott. The proposed Government Bill would mean that multiple honour crimes under specific circumstances could be assessed collectively. This would result in a strict
