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Recombinant adeno-associated viruses (AAVs) are popular in vivo gene transfer vehicles. However, vector doses needed to achieve therapeutic effect are high and some target tissues in the central nervous system remain difficult to transduce. Gene therapy trials using AAV for the treatment of neurological disorders have seldom led to demonstrated clinical efficacy. Important contributing factors are
Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human pancreatic β cells. β cell lncRNAs are often cell type specific and exhibit dynamic regulation during differentiation or upon changing glucose concentrations. Although these features hint at a role of lncRNAs in β cell gene regulation and diabetes, the function of β cell lncRNAs remains largely unknown. In this stud
Ferritin heavy chain (FTH1) is a 21-kDa subunit of the ferritin complex, known for its role in iron metabolism, and which has recently been identified as a favorable prognostic protein for triple negative breast cancer (TNBC) patients. Currently, it is not well understood how FTH1 contributes to an anti-tumor response. Here, we explored whether expression and cellular compartmentalization of FTH1
We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells (Fh1βKO mice) appear normal for 6–8 weeks but then develop progressive glucose intolerance and diabetes. Glucose tolerance is rescued by expression of mitochondrial or cytosolic FH but not by deletion of Hif1α or Nrf2. Progressive hyperglycem
Soil organic matter (SOM) supports the Earth's ability to sustain terrestrial ecosystems, provide food and fiber, and retains the largest pool of actively cycling carbon. Over 75% of the soil organic carbon (SOC) in the top meter of soil is directly affected by human land use. Large land areas have lost SOC as a result of land use practices, yet there are compensatory opportunities to enhance prod
We conducted pooled and meta-analyses of the association of the calpain-10 gene (CAPN10) polymorphisms SNP-43, Indel-19 and SNP-63 individually and as haplotypes with type 2 diabetes (T2D) in 3237 patients and 2935 controls of European ancestry. In the pooled analyses, the common SNP-43*G allele was associated with modest but statistically significant increased risk of T2D (odds ratio (OR) = 1.11
BACKGROUND: Circulating adiponectin and leptin have been associated with risk of pancreatic cancer. However, the relationship between long-term exposure to these adipokines in the prediagnostic period with patient survival has not been investigated.METHODS: Adipokine levels were measured in prospectively collected samples from 472 patients with pancreatic cancer. Because of sex-specific difference
Background. Primary glomerular disease (PGD) is a major cause of end-stage kidney disease (ESKD) leading to kidney replacement therapy (KRT). We aimed to describe incidence (trends) in individuals starting KRT for ESKD due to PGD and to examine their survival and causes of death. Methods. We used data from the European Renal Association (ERA) Registry on 69 854 patients who started KRT for ESKD du
AIMS: Cellular communication network factor 2 (CCN2) is a matricellular protein implicated in fibrotic diseases, with ongoing clinical trials evaluating anti-CCN2-based therapies. By uncovering CCN2 as abundantly expressed in non-diseased artery tissue, this study aimed to investigate the hypothesis that CCN2 plays a pivotal role in maintaining smooth muscle cell (SMC) phenotype and protection aga
Three metabolite patterns have previously shown prospective inverse associations with the risk of aggressive prostate cancer within the European Prospective Investigation into Cancer and Nutrition (EPIC). Here, we investigated dietary and lifestyle correlates of these three prostate cancer-related metabolite patterns, which included: 64 phosphatidylcholines and three hydroxysphingomyelins (Pattern
Här hittar du som chef information om förläggning av semester och sparad semester. Innehåll på sidan:Allmänt om semesterFörläggning av semesterÅrscykler för semesterplaneringChecklista för semesteruppföljningOm ni inte är överens om semesterns förläggningSparade semesterdagarSjukdom eller behov av annan ledighet under semesterEnskild överenskommelse om att avstå semestertillägg till förmån för tre
https://www.hr-webben.lu.se/anstallning/semester-och-ledigheter/hantera-semester - 2026-07-21
Anders SjögrenStraffrättsliga förhållningsregler – En rättsvetenskaplig studie av förbuds-, påbuds- och permissivregler som riktar sig till enskildaDatum för disputation: fredagen den 14 oktoberFakultetsopponent: professor em Dan Frände, Helsingfors universitetÄmne: straffrättAbstractThis thesis focuses on conduct rules in criminal law. Such rules prohibit, proscribe and permit different courses o
https://www.jur.lu.se/forskning/disputationer/disputationer-2022 - 2026-07-21
Allmänna presentationer / Presentations to the general publicPatrik Zapata, Panel discussion "What is responsible consumption?" 28/2 2019. Panelists Ulrika Holmberg, senior lecturer in Marketing at the Department of Business administration and Co-director of Centre for Consumer Science at Handelshögskolan vid Göteborgs universitet, Patrik Zapata, Professor at Förvaltningshögskolan vid Göteborgs un
https://www.ses.lu.se/fran-avfallshantering-till-avfallsforebyggande-0/presentationer-presentations - 2026-07-21
Studierektor för grundutbildning Kontaktinformation E-post: martin [dot] magnusson [at] fysik [dot] lu [dot] se Telefon: +46 46 222 14 10 Mobil: +46 73 086 48 53Organisation Fasta tillståndets fysik Besöksadress: Professorsgatan 1, Rumsnummer: B211 Hämtställe: 14 WebbplatsMartin Magnussons profil i Lunds universitets forskningsportalAndra roller Studierektor Nationellt Resurscentrum för Fysik Medl
https://www.fysik.lu.se/martin-magnusson - 2026-07-22
Brevmall Postadress Box 117, 221 00 LUND Telefon växel 046-222 00 00 Telefax 046-222 41 70 E-post info@med.lu.se Internet http://www.med.lu.se Medic inska faku l tetsstyre l sen Allmän studieplan för utbildning på forskarnivå inom det vårdvetenskapliga området - arbetsterapi, omvårdnad, sjukgymnastik http://www.med.lu.se/utbildning/forskarutbildning (Fastställd av Medicinska fakultetsstyrelsen 200
https://www.intramed.lu.se/sites/intramed.lu.se/files/2022-12/allman-studieplan-vardvetenskap-2012-01-01.pdf - 2026-07-23
Rapport vecka 44 (publicerad 2020-11-04) COVID Symptom Study Innehåll Bakgrund 2 Metod 2 Etiskt godkännande 5 Aktuell status 5 10 postnummerområden med lägst andel studiedeltagare med symtom överensstämmande med covid-19 den 2 november . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Störst ökning senaste 7 dagarna . . . . . . . . . . . . . . . . . . . . . . . . . .
https://www.covid19app.lu.se/sites/covid19app.lu.se/files/rapport_vecka44_coss.pdf - 2026-07-23
Rapport vecka 48 (publicerad 2020-12-02) COVID Symptom Study Innehåll Bakgrund 2 Metod 2 Etiskt godkännande 5 Aktuell status 5 10 postnummerområden med högst andel studiedeltagare med symtom överensstämmande med covid-19 den 30 november . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 10 postnummerområden med lägst andel studiedeltagare med symtom överensstämmande med
https://www.covid19app.lu.se/sites/covid19app.lu.se/files/rapport_vecka48_coss.pdf - 2026-07-23
Rapport vecka 4 (publicerad 2021-02-03) COVID Symptom Study Innehåll Bakgrund 2 Metod 2 Etiskt godkännande 4 Aktuell status 4 10 postnummerområden med högst uppskattad förekomst av symtomatisk covid-19 2 februari . . . 6 10 postnummerområden med lägst uppskattad förekomst av symtomatisk covid-19 2 februari . . . 8 Störst ökning senaste 7 dagarna . . . . . . . . . . . . . . . . . . . . . . . . . .
https://www.covid19app.lu.se/sites/covid19app.lu.se/files/rapport_vecka4_coss.pdf - 2026-07-23
Rapport vecka 53 (publicerad 2021-01-07) COVID Symptom Study Innehåll Bakgrund 2 Metod 2 Etiskt godkännande 5 Aktuell status 5 10 postnummerområden med högst andel studiedeltagare med symtom överensstämmande med covid-19 den 5 januari . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 10 postnummerområden med lägst andel studiedeltagare med symtom överensstämmande me
https://www.covid19app.lu.se/sites/covid19app.lu.se/files/rapport_vecka53_coss.pdf - 2026-07-23
Kursbudget Välj kurs HT21 ERROR:#N/A tc={12BF3CFE-92F6-4F3E-A11B-915CDFB72DA4}: [Threaded comment] Your version of Excel allows you to read this threaded comment; however, any edits to it will get removed if the file is opened in a newer version of Excel. Learn more: https://go.microsoft.com/fwlink/?linkid=870924 Comment: Översiktlig koll påå om tilldelning och antal studenter är med. Kursansvarig
https://www.biologyeducation.lu.se/sites/biologyeducation.lu.se/files/2022-03/KursbudgetmallHT21.xlsx - 2026-07-23
