Filtyp
With the advent of multimodality therapy, the overall five-year survival rate from childhood cancer has improved considerably now exceeding 80% in developed European countries. This growing cohort of survivors, with many years of life ahead of them, has raised the necessity for knowledge concerning the risks of adverse long-term sequelae of the life-saving treatments in order to provide optimal sc
Background. Primary glomerular disease (PGD) is a major cause of end-stage kidney disease (ESKD) leading to kidney replacement therapy (KRT). We aimed to describe incidence (trends) in individuals starting KRT for ESKD due to PGD and to examine their survival and causes of death. Methods. We used data from the European Renal Association (ERA) Registry on 69 854 patients who started KRT for ESKD du
AIMS: Cellular communication network factor 2 (CCN2) is a matricellular protein implicated in fibrotic diseases, with ongoing clinical trials evaluating anti-CCN2-based therapies. By uncovering CCN2 as abundantly expressed in non-diseased artery tissue, this study aimed to investigate the hypothesis that CCN2 plays a pivotal role in maintaining smooth muscle cell (SMC) phenotype and protection aga
BACKGROUND: Circulating adiponectin and leptin have been associated with risk of pancreatic cancer. However, the relationship between long-term exposure to these adipokines in the prediagnostic period with patient survival has not been investigated.METHODS: Adipokine levels were measured in prospectively collected samples from 472 patients with pancreatic cancer. Because of sex-specific difference
Ferritin heavy chain (FTH1) is a 21-kDa subunit of the ferritin complex, known for its role in iron metabolism, and which has recently been identified as a favorable prognostic protein for triple negative breast cancer (TNBC) patients. Currently, it is not well understood how FTH1 contributes to an anti-tumor response. Here, we explored whether expression and cellular compartmentalization of FTH1
We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells (Fh1βKO mice) appear normal for 6–8 weeks but then develop progressive glucose intolerance and diabetes. Glucose tolerance is rescued by expression of mitochondrial or cytosolic FH but not by deletion of Hif1α or Nrf2. Progressive hyperglycem
Soil organic matter (SOM) supports the Earth's ability to sustain terrestrial ecosystems, provide food and fiber, and retains the largest pool of actively cycling carbon. Over 75% of the soil organic carbon (SOC) in the top meter of soil is directly affected by human land use. Large land areas have lost SOC as a result of land use practices, yet there are compensatory opportunities to enhance prod
Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human pancreatic β cells. β cell lncRNAs are often cell type specific and exhibit dynamic regulation during differentiation or upon changing glucose concentrations. Although these features hint at a role of lncRNAs in β cell gene regulation and diabetes, the function of β cell lncRNAs remains largely unknown. In this stud
We conducted pooled and meta-analyses of the association of the calpain-10 gene (CAPN10) polymorphisms SNP-43, Indel-19 and SNP-63 individually and as haplotypes with type 2 diabetes (T2D) in 3237 patients and 2935 controls of European ancestry. In the pooled analyses, the common SNP-43*G allele was associated with modest but statistically significant increased risk of T2D (odds ratio (OR) = 1.11
Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels by stimulation of hepatic glucose production. This counterregulatory mechanism is impaired in diabetes. Here we show in mice that therapeutic concentrations of insulin inhibit g
Recombinant adeno-associated viruses (AAVs) are popular in vivo gene transfer vehicles. However, vector doses needed to achieve therapeutic effect are high and some target tissues in the central nervous system remain difficult to transduce. Gene therapy trials using AAV for the treatment of neurological disorders have seldom led to demonstrated clinical efficacy. Important contributing factors are
We assessed the association between 1,414 single nucleotide polymorphisms (SNPs) in genes involved in synthesis and metabolism of steroid hormones and insulin-like growth factor 1, and risk of breast cancer in situ (BCIS), with the aim of determining whether any of these were disease specific. This was carried out using 1,062 BCIS cases and 10,126 controls as well as 6,113 invasive breast cancer c
Three metabolite patterns have previously shown prospective inverse associations with the risk of aggressive prostate cancer within the European Prospective Investigation into Cancer and Nutrition (EPIC). Here, we investigated dietary and lifestyle correlates of these three prostate cancer-related metabolite patterns, which included: 64 phosphatidylcholines and three hydroxysphingomyelins (Pattern
Verksamhetsberättelse 2016 Institutionen för kliniska vetenskaper, Malmö (IKVM) Institutionen för kliniska vetenskaper, Malmö (IKVM) Telefon (vxl): 040-39 10 00 Hemsida: www.med.lu.se/ikvm Postadress: Institutionskansliet för kliniska vetenskaper, Malmö Clinical Research Centre Box 50332 202 13 Malmö Besöksadress: Clinical Research Centre (CRC) Jan Waldenströms gata 35, Malmö Hus 92, plan 11
https://www.medicin.lu.se/sites/medicin.lu.se/files/verksamhetsberattelse_ikvm_2016_170612.pdf - 2026-06-28
BanretiPoster.ppt 1 RESTRICTED DISCRIMINATION BETWEEN LOCAL ECONOMY AND GLOBAL ECONOMY IN AGRAMMATIC APHASIA Zoltán BÁNRÉTI Research Institute for Linguistics of the Hungarian Academy of Sciences, Budapest, Hungary banreti@nytud.hu The problem : binding principles in aphasia 1. The economy constraints of the grammar is somehow restricted in the performance of agrammatic aphasic subjects ( Vasi_-Av
https://konferens.ht.lu.se/fileadmin/user_upload/sol/ovrigt/konferens_BrainTalk/Banreti.pdf - 2026-06-27
Microsoft Word - Abstracts Social Complexes.docx ABSTRACTS Social Complexes: Parts and Wholes. Perspectives from Metaphysics, Ethics and Philosophy of Action. Department of Philosophy, Lund University, 11-‐12 October 2013 http://www.fil.lu.se/institutionen/anknuten-‐verksamhet/konferenser/social-‐complexes-‐parts-‐and-‐wholes-‐perspectives-‐ from-‐metaphysics-
https://www.fil.lu.se/fileadmin/user_upload/fil/dokument/Konferenser/Social_Complexes/Abstracts_Social_Complexes.pdf - 2026-06-27
A widespread and persistent drought plagued much of northern Mexico during the 1950’s Abrupt and Persistent Declines in Regional Precipitation Patterns: Societal Implications and Geographic Patterns Rachel Licker 199 Babbitt Rd. #2B Bedford Hills, NY 10507 USA Rachel.Licker.393@students.lu.se + 001 (608) 852-6374 Lund University Centre for Sustainability Studies in collaboration with Center for Su
https://www.lumes.lu.se/sites/lumes.lu.se/files/rachel_licker.pdf - 2026-06-28
FINAL SIMS26 190826.pdf SIMS26 GRADUATE SCHOOL, FACULTY OF SOCIAL SCIENCES, LUND UNIVERSITY Migration and Development Version 1.0, August 2019 For an always up-to-date online version, please visit the course site (check regularly for updates) Welcome! SIMS26 Welcome to the Autumn term’s course Migration and Development This interdisciplinary course deals with key issues and problems of migration
https://www.graduateschool.sam.lu.se/sites/graduateschool.sam.lu.se/files/final_sims26_190826.pdf - 2026-06-28
Association of Gluten Intake During the First 5 Years of Life With Incidence of Celiac Disease Autoimmunity and Celiac Disease Among Children at Increased Risk Association of Gluten Intake During the First 5 Years of Life With Incidence of Celiac Disease Autoimmunity and Celiac Disease Among Children at Increased Risk Carin Andrén Aronsson, PhD; Hye-Seung Lee, PhD; Elin M. Hård af Segerstad, MSc;
https://www.teddy.lu.se/sites/teddy.lu.se/files/jama_andrn_aronsson_2019.pdf - 2026-06-28
