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In this study, nickel pattern electrodes were electrochemically investigated in a three-electrode setup, operating both with H-2/H2O and CO/CO2 atmospheres. Heating introduced structural differences in the nickel layer among the pattern electrodes, which appear to affect the electrode performance. Both dense and porous nickel pattern electrodes were formed by heating. Holes appeared in the nickel
Early-life inorganic arsenic exposure influences not only child health and development but also health in later life. The adverse effects of arsenic may be mediated by epigenetic mechanisms, as there are indications that arsenic causes altered DNA methylation of cancer-related genes. The objective was to assess effects of arsenic on genome-wide DNA methylation in newborns. We studied 127 mothers a
Objectives To assess HIV knowledge, attitudes, sexual practices and sexual and reproductive health ( SRH) service delivery in border areas of Tanzania, with a view to support the prioritisation of SRH interventions in border areas. Methods The target sample comprised randomly selected people living near the border, aged 15 to 49 years. To gather information, we utilised: (i) a standardised questio
Aqueous dispersions of charged-neutral block copolymers (poly(acrylamide)-b-poly(acrylate)) complexed with an oppositely charged surfactant (dodecyltrimethylammonium) have been prepared by different approaches: the simple mixing of two solutions (MS approach) containing the block copolymer and surfactant, with their respective simple counterions, and dispersion of a freeze-dried complex salt prepa
Prognostic tools are an essential component of the clinical management of patients with renal cell carcinoma (RCC). Although tumour stage and grade can provide important information, they fail to consider patient- and tumour-specific biology. In this study, we set out to find a novel molecular marker of RCC by using hepatocyte nuclear factor 4A (HNF4A), a transcription factor implicated in RCC pro
Migration has a global impact, but it also intersects with local and nationalissues. In 2020, 281 million people lived outside their country of birth or citizenship, according to the United Nations Global Migration Database. The number of persons displaced across international borders is increasing due to conflict, persecution, and violence. Most of the world’s refugees and asylum seekers live i
Objective: To investigate the impact of including fluorine-18 fludeoxyglucose (18F-FDG) positron emission tomography (PET) scanning in the planning of paediatric radiotherapy (RT). Methods: Target volumes were first delineated without and subsequently re-delineated with access to 18F-FDG PET scan information, on duplicate CT sets. RT plans were generated for three-dimensional conformal photon RT (
In winter, a challenge to the immune system could pose a major energetic trade-off for small endotherms, whereby increasing body temperature (Tb; i.e. eliciting fever) may be beneficial to fight off invading pathogens yet incur a cost for vital energy-saving mechanisms. Having previously shown that the availability and acquisition of energy, through manipulation of food predictability, influences
Fluvial floods are commonly studied as an occurrence at the level of a specific basin and are speculated to be closely related to the basin's morphometry. It is possible to identify and rank sub-basins based on how susceptible they are to fluvial flooding events using morphometric criteria. However, one of the key causes that triggers fluvial flooding is the increase in precipitation extremes and
Background: Preoperative inflammation might cause and also be a marker for anastomotic leakage after anterior resection for rectal cancer. Available biomarker indices such as the modified Glasgow Prognostic Score (mGPS) or the C-reactive protein-to-albumin ratio (CAR) may be clinically useful for leakage assessment. Methods: Patients who underwent anterior resection for rectal cancer during 2014–2
Background: Intra-tumour heterogeneity (ITH) causes diagnostic challenges and increases the risk for disease recurrence. Quantification of ITH is challenging and has not been demonstrated in large studies. It has previously been shown that deep learning can enable spatially resolved prediction of molecular phenotypes from digital histopathology whole slide images (WSIs). Here we propose a novel me
Glucagon is the principal glucose-elevating hormone that forms the first-line defence against hypoglycaemia. Along with insulin, glucagon also plays a key role in maintaining systemic glucose homeostasis. The cells that secrete glucagon, pancreatic α-cells, are electrically excitable cells and use electrical activity to couple its hormone secretion to changes in ambient glucose levels. Exactly how
We reconstruct Quantum Mechanics in a way that harmonizes with classical mechanics and electromagnetism, free from mysteries or paradoxes such as the collapse of the wave function or Schrödinger’s cat. The construction is inspired by de Broglie’s and Schrödinger’s wave mechanics, while the unifying principle is Hamilton’s principle of least action, which separates natural laws from particular circ
Background: In addition to peripheral neuropathy of various kinds, diabetes can also cause central neuropathy, which among other things can manifest itself as premature cognitive dysfunction, often linked to vascular dysfunction. Although the link between diabetes and cognitive dysfunction was discovered more than 100 years ago and has important clinical implications, this diabetes complication re
We present new true triaxial compression data obtained in the ductile regime on Bleurswiller sandstone. The deformed samples show a range of failure modes qualitatively similar to what was reported by earlier experimental studies performed in conventional conditions (axisymmetric compression). In particular, visual inspection and X-ray Computed Tomography imaging reveal compaction localization in
Notch wear often determines tool life when machining stainless steel. Chemical Vapour Deposited (CVD) Al2O3/Ti(C,N) coated cemented carbide tools are the first recommendation for turning of stainless steel. The CVD coating plays a vital role in reducing and delaying tool wear progress. Hence, it is essential to understand the interaction between the initiation of notch wear and the coating degrada
Drawing on the quest to improve inclusion and social sustainability in urban planning process, a holistic approach on citizen participation in urban development is becoming increasingly important. One sector of society whose democratic rights remain overlooked in participatory action is children. It is therefore imperative to develop methods for processing the children’s rights to express their op
Given that urban planning has served colonial and imperialist purposes, this commentary explores the existing challenges for early-career researchers conducting research designed in the Global North and carried out in/on the Global South. We offer a series of questions and provocations as an invitation to colleagues facing similar dilemmas to reflect on their own research from a decolonial methodo
The emergence of the modern urban water system in Iran, albeit facilitated access to clean water and accelerated discharge of waste- and stormwater, it left some negative imprints on country’s urban and natural environment. Among which larger stress on natural water cycles and pollution of water resources are of great importance. More importantly, such impacts are occurring when cities are going t
