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This paper describes a heterogeneous competitive flow immunoassay with a high sample throughput which can be used for the screening of smaller analytes in various samples. The method is based on off-line incubation of the analyte (Ag), a fluorescent labelled tracer (Ag*) and the corresponding antibody (Ab). The separation of bound (Ab-Ag*) and free tracer (Ag*) is based on a size exclusion and rev
Background: Patients with squamous cell skin cancer (SCC) have an excellent prognosis but second primary cancers (SPCs) weaken survival prospects. Family history is a known risk factor for cancer but whether it is a risk factor for SPC in patients with SCC is not known. Objectives: To quantify the risk of family history on SPCs in patients with SCC and estimate survival probabilities of patients w
Common bird species were screened during May and June 2007 on Barbados for haemosporidian parasites (Haemosporida) of the genera Haemoproteus and Plasmodium to determine whether the low parasite diversity reported in previous studies might have reflected limited sampling. PCR screening and DNA sequencing revealed a single predominant lineage of Haemoproteus identified as H. coatneyi. Sixty-two out
Water molecules play important roles in all biochemical processes. Therefore, it is of key importance to obtain information of the structure, dynamics, and thermodynamics of water molecules around proteins. Numerous computational methods have been suggested with this aim. In this study, we compare the performance of conventional and grand-canonical Monte Carlo (GCMC) molecular dynamics (MD) simula
Background: Plasmodium falciparum parasites cause malaria and co-exist in humans together with B-cells for long periods of time. Immunity is only achieved after repeated exposure. There has been a lack of methods to mimic the in vivo co-occurrence, where cells and parasites can be grown together for many days, and it has been difficult with long time in vitro studies. Methods and results: A new me
We investigated the sequential protein expression in gingival crevicular fluid samples during the induction (I) and resolution (R) of experimental gingivitis. Periodontally and systemically healthy volunteers (n = 20) participated in a three-week experimental gingivitis protocol, followed by debridement and two weeks of regular plaque control. Gingival crevicular fluid (GCF) samples were collected
Cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) are increasingly used in research centers, clinical trials, and clinical settings. However, their broad-scale use is hampered by lack of standardization across analytical platforms and by interference from binding of amyloid-beta(A beta) to matrix proteins as well as self-aggregation. Here, we report on a matrix effect-resistant met
Advances in liquid chromatography–mass spectrometry have significantly improved proteomic analyses of human plasma. However, information at the level of intact proteoforms remains limited due to the high dynamic range of protein abundance and the complexity of post-translational modifications. To address this challenge, we introduce soluble plasma proteoform analysis via acetonitrile precipitation
Artificial intelligence (AI) is increasingly employed in crisis communication to assist with tasks like monitoring, analysis, and message creation. However, its expanding use raises ethical and responsibility concerns, especially when AI-supported communication results in problematic outcomes. This thesis aims to provide new knowledge and enhance the understanding of how Estonian communication pro
The aim of this work is to investigate how a quantised photon cavity modifies the spin dynamics of a two-site spin-electron dimer with Rashba spin-orbit coupling. The cavity couples to inter-site hopping through the Peierls substitution. Dissipation is included via the Lindblad master equation. Three numerical methods were tested to see which would be best suited for the time evolution of the syst
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https://www.iac.lu.se/sites/iac.lu.se/files/2024-10/DeepListening_presskit.pdf - 2026-07-23
Brevmall 6 Research Collaboration Agreement between Lund University (“LU”), registration no. 202100-3211, with address P. O. Box 117, SE-221 00 Lund, Sweden; and [organisation name] (“[abbreviation of organisation name]”), organisation registration no. [organisation registration no.], duly organised under the laws of [country], with address [address]; each also referred to as a “Party” and jointly
Objectives Prothrombin complex concentrates have been used to correct dilutional coagulopathy, but many preparations contain anticoagulants, such as heparin, to counteract their prothrombotic effects. These anticoagulants can interfere with haemostatic assays. The aim of this study was to monitor two different prothrombin complex concentrates for the treatment of albumin dilution in vitro, using r
För att uppnå Parisavtalets klimatmål att begränsa den globala uppvärmningen till under 2 grader, samt sträva efter att begränsa ökningen till under 1,5 grader Celsius, krävs en omställning till klimatmässiga och hållbara finansieringar med låga utsläpp. En finansieringsform som har pekats ut för att så långt som möjligt uppnå Parisavtalet och klara omställningen att förflytta kapital mot mer hållIn order to achieve the Paris Agreement’s climate goals, to limit global warming to well below 2 °C, and to pursue efforts to limit it to 1.5 degrees Celsius, a transition from carbon-intensive to low-emission investments is needed. Green bonds have been identified as an important instrument to achieve the transition since green bonds can provide a long-term debt capital to low-emission projects b
Nuclear magnetic resonance (NMR) spectroscopy was used in order to investigate the relationships between structure, dynamics and calcium binding in the intracellular regulatory protein, calmodulin. Calmodulin consists of two similar domains, each binding two calcium ions with positive cooperativity. The studies described in this thesis focus on the isolated C-terminal domain, TR2C, and two mutants
Murine monoclonal antibodies against the major cysteine proteinase inhibitors of human biological fluids, cystatin C and kininogen, were produced. The cystatin C antibody, HCC3, with a Ka of 2times107 l/mol, increased the inhibition of papain by cystatin C and was suitable for use in immunoblotting, immunohistochemistry and in the construction of a sensitive sandwich enzyme immunoassay for quantif
This thesis presents a complete digital back-end implementation of a PN-dither least-mean-squares (LMS) background calibration scheme for a 12-bit, 500 MS/s pipeline analog-to-digital converter (ADC). The target converter, designed by a parallel analog project, comprises four 3-bit stages and a 4-bit final flash stage; its actual inter-stage gains depart substantially from their nominal values, re
Lund University in brief 2022 Lund University 2022 | EDUCATION, RESEARCH AND COLLABORATION SINCE 1666 A WORLD-CLASS UNIVERSITY To understand, explain and improve Lund University was founded in 1666 and, ever since, has been a centre of culture and learning. One of our strengths is our unique disciplinary range and our ability to generate boundary-crossing collaboration. Student influence, internat
https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2022-05/Presentationbrochure-2022-ENG.pdf - 2026-07-23
BACKGROUND: Fetal cardiovascular MRI complements ultrasound to assess fetal cardiovascular pathophysiology.PURPOSE: To develop a free-breathing method for retrospective fetal cine MRI using Doppler ultrasound (DUS) cardiac gating and tiny golden angle radial sampling (tyGRASP) for accelerated acquisition capable of detecting fetal movements for motion compensation.STUDY TYPE: Feasibility study.SUB
