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Bisphenol A (BPA) is an endocrine-disrupting chemical restricted by EU legislation. Consequently, the industry has transitioned to structurally similar substitutes, primarily bisphenol S (BPS) and bisphenol F (BPF). This study aimed to investigate temporal trends in population exposure to BPA, BPS and BPF among adolescents in Skåne, Sweden, between 2000 and 2022 through measured urinary concentrat
The last two decades have seen considerable advancements in biometric technology, and consequently its use as a surveillance measure during occupation. The increasingly invasive and omniscient nature of biometric surveillance technologies means they constitute a considerable infringement on the private sphere of occupied populations, and consequently an interference with their right to privacy. Th
This master’s thesis focused on the crystallisation of E. coli ribonucleotide reductase repressor (NrdR) in the scope of fragment-based drug design. Antibiotic resistance is a growing problem and NrdR is thought to be a potential drug target for a new group of antibiotics. NrdR proteins are only found in bacteria and regulate the transcription of ribonucleotide reductase genes by binding to two Nr
Microplastics are becoming an increasingly bigger problem, and there are currently around 150 million tons of plastic in the ocean. Most plastic in the ocean was released on land and then transported to the ocean. There are, however, microplastics released directly into the ocean, for example from boat paint. This study will investigate paint microplastic released from the storage area in a Swedis
Acidification-threatened marine ecosystems and competition for land use along the coasts are merely some of the consequences of the climate crisis. A technology with growing interest that can contribute to solutions for these consequences is Biorock. As a nature-inspired approach based on electrolysis of seawater, Biorock offers two solutions in one technology; eco-friendly materials grown directl
Here, we use carbon dioxide (CO2), methane (CH4), carbon monoxide (CO), nitrous oxide (N2O) and radon (222Rn) data from the Saclay ICOS tall tower in France to estimate CO2, CH4 and CO fluxes within the station footprint from January 2017 to October 2024 and N2O fluxes from February 2019 to October 2024 using the Radon Tracer Method (RTM). We first performed a sensitivity study of this method appl
Key message: A candidate gene exhibiting pleiotropic effect on twelve different seed size and weight traits was identified through a combination of evidence from population genetic selection, GWAS, earlier QTL studies, transcriptome analysis, and transgenic analyses. Abstract: Peanut is an important oilseed crop. Seed weight and size significantly impact yield, leading to the identification of num
Structural optimization aims to find the geometry of the best performing design in a predefined setting, using mathematical techniques. The motivation for this study can be categorized into three main benefits: efficient material usage, enhancing existing designs and enabling new technologies. All of these benefits are crucial for solving contemporary technological and environmental challenges. An
BACKGROUND: So far, the ImmuKnow Immune Cell Function Assay (Cylex, Inc., Columbia, MD, USA) has been used to assess risks of infection and rejection in transplant patients. We hypothesized that the ImmuKnow assay might be used for mortality screening in transplant patients overall.METHODS: In the period of February 2007 to December 2009, at the Uppsala University Hospital, 362 patients who receiv
Atmospheric inverse modelling and ecosystem data assimilation are two complementary approaches to estimate CH4 emissions. The inverse approach infers emission estimates from observed atmospheric CH4 mixing ratio, which provide robust large scale constraints on total methane emissions, but with poor spatial and process resolution. On the other hand, in the ecosystem data assimilation approach, the
Context. The chemical abundances of alpha elements in Galactic Centre (GC) supergiants provide key insights into the chemical enrichment and star formation history of the Milky Way’s nuclear star cluster. Previous studies have reported enhanced alpha-element abundances, which raises questions about the chemical evolution of this unique region. Aims. We aim to reassess the alpha-element abundances
Sacituzumab govitecan (SG) is an antibody-drug conjugate (ADC) targeting TROP2, which has recently been approved for treatment-refractory metastatic urothelial cancer (UC). However, the variability of TROP2 expression across different bladder cancer (BC) subtypes, as well as after enfortumab vedotin (EV) exposure, remains unknown. Using gene expression data from four clinical cohorts with >1400 pa
