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BACKGROUND: Gastrectomy including D2 lymphadenectomy is regarded as the standard curative treatment for advanced gastric cancer in Asia. This procedure has also been adopted gradually in the West, despite lack of support from RCTs. This study sought to investigate any advantage for long-term survival following D2 lymphadenectomy in routine gastric cancer surgery in a Western nationwide population-

Objective: An artefact-free electrocardiogram (ECG) is essential during cardiac arrest to decide therapy such as defibrillation. Mechanical cardiopulmonary resuscitation (CPR) devices cause movement artefacts that alter the ECG. This study analyzes the effectiveness of mechanical CPR artefact suppression filters to restore clinically relevant ECG information. Approach: In total, 495 10 s ECGs were

Objective: To identify circulating angiogenic and inflammatory biomarkers with potential in screening for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc), and in early diagnosis and determination of treatment response in PAH. Method: Plasma samples were taken at the time of PAH diagnosis and at treatment follow-up after a median (interquartile range) of 4 months (3–9.8 months) in

This thesis proposes a unique quantitative investigation of the long-term development of modern states in Sub-Saharan Africa. This is done by measuring and analysing the dynamic history of tax revenue, as a key measure of the capacity of the state, and development in four countries in francophone West Africa – Benin, Côte d’Ivoire, Niger and Senegal – over the long 20th century. This approach cont

We have recently shown that the human Nuclear pore-associated protein (NPAP1)/C15orf2 gene encodes a nuclear pore-associated protein. This gene is one of several paternally expressed imprinted genes in the genomic region 15q11q13. Because the Prader–Willi syndrome is known to be caused by the loss of function of paternally expressed genes in 15q11q13, a phenotypic contribution of NPAP1 cannot be e

Background: Patients with asthma and elevated blood eosinophils are at increased risk of severe exacerbations. Management of these patients should consider nonadherence to inhaled corticosteroid (ICS) therapy as a factor for increased exacerbation risk. Objective: The objective of this study was to investigate whether poor adherence to ICS therapy explains the occurrence of asthma exacerbations in

A paleomagnetic and chronogical study has been performed on the Turinge gabbro-diabase formation and on a cross cutting basic dyke in central Sweden and on the Joulovaara gabbro intrusion in northern Sweden in the Fennoscandian Shield. U-Pb age of baddeleyite and 40Ar/39Ar ages of hornblende and biotite reveal a cooling history of the deep gabbro-diabase intrusion in Turinge. The cooling is sugges

The tumor microenvironment consists of several interacting cell types. Cancer research focssed mainly on the malignant cell in the past. The importance of the tumor microenvironment is increasingly appreciated, as endothelial cells and immune cells were identified as targets for anti-tumor therapy. Targeted therapy against cancer-associated fibroblasts (CAFs) are not in clinical use for the treatm

Evidence for unbroken continuity of tree taxa over the last c. 13,500 years is presented from a biodiversity ‘hotspot’ nature reserve in south-west Sweden.Forest composition, continuity, fire and disturbance events are reconstructed using palaeoecological methods. A lake record reveals that Pinus sylvestris,Betula spp., Salix spp., Populus tremula and Hippophae rhamnoides were the initial trees sc