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Inhibition of mitochondrial permeability transition (mPT) has emerged as a promising approach for neuroprotection and development of well-tolerated mPT inhibitors with favorable blood-brain barrier penetration is highly warranted. In a recent study, 28 clinically available drugs with a common heterocyclic structure were identified as mPT inhibitors e.g. trifluoperazine, promethazine and nortriptyl
BACKGROUND: The P-value approach has been employed to prioritizing genome-wide association (GWA) scan signals, with a genome-wide significance defined by a prior P-value threshold, although this is not ideal. A rationale put forward is that the association signals rather should be expected to give less support for single nucleotide polymorphisms (SNPs) that are rare (with associated low-power test
OBJECTIVES: To evaluate diagnostic performance and actual costs in clinical practice of IgG/IgA deamidated gliadin peptide antibodies (DGP) as a complement to IgA antibodies against tissue transglutaminase (tTG) for the diagnosis of pediatric celiac disease (CD). PATIENTS AND METHODS: All consecutive patients <18 years tested for tTG and/or DGP and who underwent duodenal biopsy because of suspec
A deficient retinoic acid signaling has been suggested to be an important cause of the clinical inefficacy of all-trans retinoic acid (ATRA) therapy in non-promyelocytic (non-PML) forms of acute myeloid leukemia (AML). The general aim of the present work was to explore novel ways to take advantage of the anti-leukemic potential of ATRA, and, specifically, to search for a synergism between ATRA and
Drug therapy is often directed to specific organ and tissue compartments where the mode of action of the compound effects specifically targeted biological processes. However, the direct measurement of drug uptake in terms of a time kinetic and concentrations attained at the local sites has not been readily available as a clinical index for most drugs. A proof-of-principle study was conducted to te
Arachidonate 15-lipoxygenase (LO)-1 has been implicated in allergic inflammation and asthma. The overall effect of 15-LO in allergic inflammation in vivo is, however, unclear. This study investigates systemic allergen sensitization and local allergic airway inflammation and remodeling in mice lacking the murine 12/15-LO, the ortholog to human 15-LO-1. Upon systemic sensitization with intraperitone
The Ile148Met (rs738409, G-allele) in the patatin-like phospholipase domain-containing protein 3 gene (PNPLA3) associates with liver fat content and may lead to loss-of-function (hydrolysis) or gain-of-function (CoA-dependent lysophosphatidic acid acyltransferase) defects. PNPLA3 is up-regulated by dietary carbohydrates, and interactions between rs738409 and carbohydrates, and sugar and ω6:ω3-poly
When light is used to study structures, the wavelength limits the size of the details that can be resolved. Visible light can be used to investigate structures as small as a micrometre in size. To study smaller structures a shorter wavelength is required. The wavelength of hard X-ray radiation is much shorter than that of visible light, and is comparable to the distance between atoms in solids and
What is Church archaeology today, and what would we like it to be tomorrow? The occasion of the 90-year birthday of professor emeritus Erik Cinthio has afforded me the opportunity to reflect upon these two questions. Departure is taken in the 19th century, when medieval churches first became a topic of interest for researchers and architects. Church archaeology developed as a sub-discipline of art
Accelerator based lightsources are one of the most powerful tools today for producing high intensity radiation at very short wavelengths. While synchrotron storage rings provide a high average brilliance in a wide wavelength range, the next generation of lightsources aim towards producing ultra-short pulses in the X-ray regime. A very promising technique implemented or proposed at many accelerat
Popular Abstract in Swedish I denna avhandling presenteras olika studier om röstimitation. Det unika i den individuella rösten och om det är möjligt att förändra sin röst så att man blir till förväxling lik någon annan vad gäller rösten och talet diskuteras. Syftet med studierna var i första hand att ta reda på hur och i vilken omfattning en imitatör förändrar sin egen röst och sitt tal för att blThis thesis is about voice imitations, more specifically impersonation. Questions are raised about the uniqueness of a person’s voice and speech behaviour and if it is possible to get close to another speaker’s voice and speech. Four main research questions are investigated in different studies. The studies focus mainly on how close the imitation is to the target speaker, and addresses to a lesser
This article aims to highlight how literary value is constructed today: how it is created and negotiated. It seeks to develop a perspective that considers the manifold and complex valuenegotiation process. In accordance with Barbara Herrnstein Smith, the article argues that literary value is generated by a constant and continuous series of negotiations between production and sale: the institution
