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Protein tyrosine phosphatases (PTPs) are crucial regulators of cellular signaling. Their activity is regulated by the motion of a conserved loop, the WPD-loop, from a catalytically inactive open to a catalytically active closed conformation. WPD-loop motion optimally positions a catalytically critical residue into the active site, and is directly linked to the turnover number of these enzymes. Cry
Enzymes are dynamic entities, and their dynamic properties are clearly linked to their biological function. It follows that dynamics ought to play an essential role in enzyme evolution. Indeed, a link between conformational diversity and the emergence of new enzyme functionalities has been recognized for many years. However, it is only recently that state-of-the-art computational and experimental
Current genetic research on obsessive-compulsive disorder (OCD) supports contributions to risk specifically from common single nucleotide variants (SNVs), along with rare coding SNVs and small insertion-deletions (indels). The contribution to OCD risk from rare copy number variants (CNVs), however, has not been formally assessed at a similar scale. Here we describe an analysis of rare CNVs called
Working from anywhere, often associated with digital nomadism, is a growing trend that blurs the boundaries between work and leisure, with individuals choosing to work from tourist destinations. The phenomenon has caught the attention of academics, who mainly focus on the lifestyle aspects of digital nomadism. However, destination management organizations, as well as the tourism and hospitality in
AI-enabled technologies are developing rapidly, but the first wave of the Digit Employers’ Digital Practices at Work Survey (2021-22) showed that their use by firms is not yet widespread. This Data Commentary presents findings from the second wave of the Survey, conducted during 2023, based on responses from 1,150 firms.The findings show that adoption of AI-enabled technologies by UK firms remains
Drug-induced cognitive impairment (DICI) is a well-established, yet under-recognised, complication of many types of pharmacological treatment. While there is a large body of scientific literature on DICI, most papers are about drug-induced dementia in the elderly and one specific drug class. However, DICI also comprises subclinical symptoms, domain-specific forms of cognitive impairment as well as
The main goal of SASPENCE is to develop and evaluate an innovative system able to perform the Safe Speed and Safe Distance concept, that means to help the driver in avoiding accident situations related to excessive speed or too small headway. So, the system should co-operate seamlessly with the driver, suggesting the proper velocity for the given condition (road structure, traffic situation, etc.)
Since some years ago greenhouse gases and especially carbon dioxide have become one of the most widely debated issues. To reduce the emission of carbon dioxide and nuclear waste, renewable energy sources as for example wind power plants have become very successful. These generation units are normally small compared to common thermal power plants and they are often placed distributed and connected
Grammatical structure of Indo-European (IE) languages may appear to be diverse, but it is in fact more systematic than one may think. What is significant in explanation is alignment, i.e. differences represent different stages in the alignment change from active one to accusative one. This means that the grammatical structure was earlier organised by aspectual differences between perfective and im
Major threats to biodiversity and ecosystem persistence are fragmentation of habitats and declining population sizes. For conservation biologists to understand the consequences of declining populations for the long term persistence and recovery of species worldwide, it is important to know and understand the underlying causes of potential threats, such as the depletion of genetic diversity, which
The analysis of evaluation in text poses significant methodological challenges, which mainly arise from the fact that: a) evaluative meanings can be expressed through an open-ended range of lexico-grammatical resources; b) they can span multiple words; c) context and co-text play a key role in determining the evaluative meaning of words or phrases; d) the interpretation of evaluation in text depen
Background: Global climate change is already increasing the average temperature and direct heat exposure in many places around the world. Objectives: To assess the potential impact on occupational health and work capacity for people exposed at work to increasing heat due to climate change. Design: A brief review of basic thermal physiology mechanisms, occupational heat exposure guidelines and heat
Through the making of courses in Rehabilitation engineering entirely over the Internet, Certec has pedagogically achieved three things. The most obvious is that our education has become more accessible for disabled students. Not so obvious was the effects that came from making the familiar strange when we were transferring to the net: It was impossible to invent a ‘net-pedagogy’ by doing anything
Popular Abstract in Swedish I denna avhandling studeras ledningsförmågan hos nanometer-stora kvantprickar tillverkade i halvledarmaterial. Halvledare är material vars ledningsförmåga ligger någonstans mellan ledare (metaller) och isolatorer. I halvledare kan ledningsförmågan ändras med elektriska fält, vilket har möjliggjort utvecklandet av halvledartransistorn. Utvecklandet av halvledartransistorThis thesis focuses on electron transport in single and double quantum dots defined in low-dimensional, narrow-band-gap III-V semiconductor materials. Fabrication schemes are presented for defining single and double quantum dots in lateral InGaAs/InP heterostructures, either by a combination of etching and local gating or solely by local top gating. The quantum dots are here electrostatically conf
Summary Sheet and Statement of Purpose – Master’s programme in Logistics and Supply Chain Management 1/7 Summary Sheet and Statement of Purpose – Master’s programme in Logistics and Supply Chain Management Questions? Please check out FAQ on: www.lth.se/english/faq Here you can also find guidelines on how to convert local credits into ECTS. Personal information (same as your universityadmissions.se
https://www.lunduniversity.lu.se/sites/www.lunduniversity.lu.se/files/2024-10/Summary-sheet-logistics_0.pdf - 2026-07-22
Microsoft Word - Biobank report 2019.docx MultiPark Biobank 1. Short description of the platform MULTIPARK'S BIOBANK SAMPLE COLLECTION Steering group: Maria Swanberg (coordinator), Oskar Hansson, Andreas Puschmann, Håkan Widner and Per Odin. Design and access to samples MultiPark's biobank sample collection (MPBC) is a resource that serves three major research areas: Biomarkers, Epidemiology and G
https://www.multipark.lu.se/sites/multipark.lu.se/files/biobank_report_2019.pdf - 2026-07-22
