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Background Excess weight gain throughout adulthood can lead to adverse clinical outcomes and are influenced by complex factors that are difficult to measure in free-living individuals. Metabolite profiling offers an opportunity to systematically discover new predictors for weight gain that are relatively easy to measure compared to traditional approaches. Methods and results Using baseline metabol

Hox genes orchestrate development by patterning the embryonic axis. Vertebrate Hox genes are arranged in four compact clusters, and the spacing between genes is assumed to be crucial for their function. The genomes of squamate reptiles are unusually rich and variable in transposable elements (TEs), and it has been suggested that TE invasion is responsible for the Hox cluster expansion seen in snak

Stroke outcome is determined by a complex interplay, where age and stroke severity are predominant predictors. Studies on hemorrhagic stroke indicate that APOE genotype is a predictor of poststroke outcomes,1,2 but results from studies on ischemic stroke are more conflicting.1,3 There is 1 study suggesting an influence of APOE genotype on age at ischemic stroke onset,4 and sex-specific effects on

‘You do not know what it means to me, to be at this kind of party, to talk to these kinds of people’, my research assistant Rodrigo told me after a soirée in the elite South Zone of Rio. ‘É uma viagem’, it’s a journey. Rodrigo, who had already worked with three anthropologists by the time I came to be his employer, thrived with the affordances of friendship, in the face of the volatility of his fa

The decoupling of energy use from economic growth is an essential element in the transition to a sustainable future. However, little is known about the long-term drivers of decoupling, especially considering the possibility that it is at least partially due to increased trade. This study uses structural decomposition analysis to examine the main factors that contribute to changes in the energy foo

This article analyses sibling farms in Sweden during the 20th century. The term sibling farm refers to a farm that two or more adult siblings have taken over from their parents. Although varied research themes have focused on a rangeof topics, this form of extended family constellation is traditionally associated with the past, whereas the smaller, nuclear family is characterized as modern. When r

Bone is a complex hierarchical structure mainly comprising of a matrix of collagen and hydroxyapatite. The main physiological functions of bone include regulating skeletal remodeling, calcium homeostasis and providing a congenial environment to the bone marrow cells to reside and these physiological processes are intricately regulated by various cell types and biomolecules. During trauma to the sk

Objectives: Experimental and small human studies have indicated that high total adiponectin levels have beneficial cardiometabolic effects. In contrast, however, high total adiponectin levels are also associated with higher all-cause and cardiovascular mortality in thoroughly adjusted epidemiological studies. To gain further insight into these seemingly contradictory results, we report results on