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Background. Randomised trials suggest that therapy with aromatase inhibitors improves survival in breast cancer compared with tamoxifen therapy in postmenopausal cases with hormone receptor positive breast cancer. Whether these results from randomized studies transform into the general population is unknown. We have therefore compared survival for all breast cancer cases in Sweden diagnosed 2000-2

This study investigated whether more patients with contact allergies were detected by patch testing with mercapto mix with a higher concentration of 2-mercaptobenzothiazolinone (MBT) than the commonly used mercapto mix. A total of 3,143 dermatitis patients in 5 Swedish dermatology departments were patch- tested with 3 mercapto test preparations: MBT 2.0% petrolatum (pet.); mercapto mix 2.0% pet.;

This article historicises the nature of political transition in Myanmar to better appreciate the challenges faced by civil society. After Myanmar’s political reforms in 2011, Western donors rushed into the country in support of what they misunderstood as a remarkable instance of democratisation. In 2019, escalating civil war, ethnic cleansing, and contracting civil liberties urge a rethink. This a

Pure 1′#,2′,3′,4′#,5′,5′'-2H6-ribonucleoside derivatives 10–14, 1′#,2′,″,3′,4′#,5′,5″-2H7-2′-deoxynucleoside blocks 15–18 and their natural-abundance counterparts were used to asemble partially deuterated ribonucleotide-dimers (∗ indicates deuteration at 1′#,2′,3′,4′#,5′,5″(2H6)): ApU∗21, GpC∗22 partially deuterated 2′-deoxyribonucleotide-dimers d(TpA∗) 23, d(ApT∗) 25, d(GpC∗26 (∗ indicates deuter

Biological substances based on proteins, including vaccines, antibodies, and enzymes, typically degrade at room temperature over time due to denaturation, as proteins unfold with loss of secondary and tertiary structure. Their storage and distribution therefore relies on a “cold chain” of continuous refrigeration; this is costly and not always effective, as any break in the chain leads to rapid lo

Drug repurposing is the use of a given therapeutic agent for indications other than that for which it was originally designed or intended. The concept is appealing because of potentially lower development costs and shorter timelines than are needed to produce a new drug. To date, drug repurposing for cardiovascular indications has been opportunistic and driven by knowledge of disease mechanisms or

Research in sustainability transitions increasingly acknowledges that the structural characteristics of socio-technical systems differ. However, little attention has been paid to the specific transition dynamics that can result from this structural variation. In response, this paper develops a framework for studying transition dynamics that takes the structural characteristics of socio-technical s