Filtyp
Objective: It has been suggested that elevated levels of C-reactive protein (CRP) might interfere with leptin signalling and contribute to leptin resistance. Our aim was to assess whether plasma levels of CRP influence leptin resistance in humans, and our hypothesis was that CRP levels would modify the cross-sectional relationships between leptin and measures of adiposity. Design and methods: We a
Popular Abstract in English A central requirement in the design of bridge, or any structure, is that they are safe and do not fail unexpectedly. To ensure that such occurrences are acceptably rare involves predicting the various ways in which the bridge can fail and ensuring that provisions are made to prevent or control these potential failure. In other words, the risks associated with failure shEngineering design, in concise terms, is what engineers do using what they know. It is the underlying decision making activity that determines what is to be built and how it should be built. An ever present requirement in engineering design is that the structure should be safe. While historical approaches to safety in design relied on experience and engineering judgment, modern approaches have rat
Background: To study the impact of social participation, trust and the miniaturisation of community, i.e. high social participation/low trust, on consumption of homemade liquor and smuggled liquor during the past year. Methods: The Scania 2000 public health survey is a cross-sectional, postal questionnaire study. A total of 13,604 persons aged 18–80 years were included. A logistic regression model
Semantic roles, logical relations such as Agent or Instrument that hold between events and their participants and circumstances, need to be determined automatically by several types of applications in natural language processing. This process is referred to as semantic role labeling. This dissertation describes how to construct statistical models for semantic role labeling of English text, and how
Columnar metaplasia, where columnar epithelium replaces the normal squamous epithelium in esophagus, is considered to be a precancerous condition in which the development of adenocarcinoma can be followed through various grades of dysplasia. The interpretation of these histological changes is subjective and suffers from considerable inter-observer variation among pathologists. In study I, we devis
Hereditary retinal degeneration (RD) relates to a heterogeneous group of blinding human diseases in which the light sensitive neurons of the retina, the photoreceptors, die. RD is currently untreatable and the underlying cellular mechanisms remain poorly understood. However, the activity of the enzyme poly-ADP-ribose polymerase-1 (PARP1) and excessive generation of poly-ADP-ribose (PAR) polymers i
BACKGROUND: The two-gene expression ratio HOXB13:IL17BR has been proposed to predict the outcome of tamoxifen-treated breast cancer patients. We intended to examine whether this ratio can predict the benefit of 5 years vs. 2 years of tamoxifen treatment of postmenopausal patients. A further objective was to investigate any prognostic effects of the ratio in systematically untreated premenopausal p
The purpose of this study was to develop a computer-assisted diagnosis (CAD) system based on image-processing techniques and artificial neural networks for the interpretation of bone scans performed to determine the presence or absence of metastases. METHODS: A training group of 810 consecutive patients who had undergone bone scintigraphy due to suspected metastatic disease were included in the st
Context: Prostate cancer (PCa) is a clinically heterogeneous disease with marked variability in patient outcomes. Molecular characterization has revealed striking mutational heterogeneity that may underlie the variable clinical course of the disease. Objective: In this review, we discuss the common genomic alterations that form the molecular basis of PCa, their functional significance, and the pot
One of the most dynamic interactions between humans and technology of our time is the development of artificial intelligence, materialized in various types of communicative robots. Thrilling questions are raised about how human-like these robots can be and how far this interaction will go. It is no exaggeration to state that speculations about the robots’ role in our lives far exceed what we know
