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Core assessment program for surgical interventional therapies in Parkinson's disease (CAPSIT-PD)

In 1992 the Core Assessment Program for Intracerebral Transplantations (CAPIT) was published providing the minimal requirements for a common patient evaluation protocol. Despite the intent, the program was thought to be too laborious to carry out in large scale trials, and it also lacked evaluations of cognitive functions and quality of life. Moreover, the CAPIT was designed for neural transplanta

Lock-in of mature innovation systems : The transformation toward clean concrete in the Netherlands

Energy-intensive processing industries like the concrete industry form the base of the economy and account for a large part of global greenhouse gas emissions. Sectoral transformation to cleaner basic materials is therefore crucial, and institutional pressure to do so is increasing. However, socio-technical studies have not sufficiently addressed these sectors. This paper therefore sets out to ana

A Puzzle About Proportionality

The paper addresses a puzzle about the proportionality requirement on self-defense due to L. Alexander. Indirectly the puzzle is also relevant to the proportionality requirement on punishment, insofar as the right to punish is derived from the right to self-defense. Alexander argues that there is no proportionality requirement on either self-defense or punishment, as long as the aggressor/offender

Industrial Intensification and Energy Embodied in Trade : Long-Run Energy Perspective of the Planned Economy of Czechoslovakia

This paper examines the role of foreign trade in the consumption of energy in Czechoslovakia through a bottom-up approach in accounting for energy embodied in trade with manufactured goods. It provides a unique analysis of annual changes in energy embodied in trade in a country characterized by changing political regimes. On the whole, Czechoslovakia has been a net exporter of energy throughout th

The mirror in-between picture and mind : A phenomenologically inspired approach to cognitive semiotics

The claim of cognitive semiotics to offer something new to semiotics rests on the ambition to bring together the research traditions of semiotics and cognitive science. Our focus has been on using the empirical approach of cognitive science in investigating semiotic issues. At the same time, however, phenomenological description plays a major part in preparing the studies and integrating their res

Islet Function in the Pathogenesis of Cystic Fibrosis-Related Diabetes Mellitus

Cystic fibrosis-related diabetes mellitus (CFRD) is the most common non-pulmonary co-morbidity in cystic fibrosis (CF). CF is caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR), which leads to aberrant luminal fluid secretions in organs such as the lungs and pancreas. How dysfunctional CFTR leads to CFRD is still under debate. Both intrinsic effects of dysfu

Grand unified origin of gauge interactions and families replication in the standard model

The tremendous phenomenological success of the Standard Model (SM) suggests that its flavor structure and gauge interactions may not be arbitrary but should have a fundamental first-principle explanation. In this work, we explore how the basic distinctive properties of the SM dynamically emerge from a unified New Physics framework tying together both flavor physics and Grand Unified Theory (GUT) c

Local Routing in Sparse and Lightweight Geometric Graphs

Online routing in a planar embedded graph is central to a number of fields and has been studied extensively in the literature. For most planar graphs no O(1)-competitive online routing algorithm exists. A notable exception is the Delaunay triangulation for which Bose and Morin (SIAM J Comput 33(4):937–951, 2004) showed that there exists an online routing algorithm that is O(1)-competitive. However

Spatially resolved spectroscopy across stellar surfaces : IV. F, G, and K-stars: Synthetic 3D spectra at hyper-high resolution

Context. High-precision stellar analyses require hydrodynamic 3D modeling. Such models predict changes across stellar disks of spectral line shapes, asymmetries, and wavelength shifts. For testing models in stars other than the Sun, spatially resolved observations are feasible from differential spectroscopy during exoplanet transits, retrieving spectra of those stellar surface segments that succes

Optical investigations and characterization of soot of different morphology and maturity

The formation path from small poorly absorbing incipient soot to larger fractal-like strongly absorbing black soot is extensive, and along this path the optical and physicochemical properties of the soot evolve. Soot emitted into the atmosphere may originate from some stage of this process, which will result in a wide spectrum of carbonaceous aerosols in the atmosphere which may interact with the

Uniaxial hydroxyapatite growth on a self‐assembled protein scaffold

Biomineralization is a crucial process whereby organisms produce mineralized tissues such as teeth for mastication, bones for support, and shells for protection. Mineralized tissues are composed of hierarchically organized hydroxyapatite crystals, with a limited capacity to regenerate when demineralized or damaged past a critical size. Thus, the development of protein‐based materials that act as a

Reconciling Flux Experiments for Quantitative Modeling of Normal and Malignant Hematopoietic Stem/Progenitor Dynamics

Hematopoiesis serves as a paradigm for how homeostasis is maintained within hierarchically organized cell populations. However, important questions remain as to the contribution of hematopoietic stem cells (HSCs) toward maintaining steady state hematopoiesis. A number of in vivo lineage labeling and propagation studies have given rise to contradictory interpretations, leaving key properties of ste

Towards sustainable water use in industry: a case study of the oil refinery industry in Kazakhstan

The concept of “Sustainable water use” (SWU) aims to assure three pillars of sustainability related to the water sector: the social, environmental, and economical. Industrial development, especially in developing countries, requires an adequate response, as industrial activities are recognized as one of the major sources of water pollution, what leads to deterioration of environmental safety and w

Gender gap in journal submissions and peer review during the first wave of the COVID-19 pandemic : A study on 2329 Elsevier journals

During the early months of the COVID-19 pandemic, there was an unusually high submission rate of scholarly articles. Given that most academics were forced to work from home, the competing demands for familial duties may have penalized the scientific productivity of women. To test this hypothesis, we looked at submitted manuscripts and peer review activities for all Elsevier journals between Februa

A Network Analysis to Identify Associations between PTSD and Dissociation among Teenagers

We conducted a network analysis of measures of dissociation and posttraumatic symptoms (PTS) with a varied sample of adolescents (N = 312), some of them previously exposed to war scenarios. The global measure of dissociation (A-DES) was uniquely linked to the arousal PTS symptom cluster (CRIES-13), in particular sleep problems, but not to the reexperiencing and avoidance clusters. Three of four (i