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Popular Abstract in Swedish Gliom är en familj av hjärntumörer som är graderade beroende på hur snabbt och på vilket sätt de växer. Grad IV även kallad glioblastoma multiforme, är den mest elakartade av dessa. Patienter har en medelöverlevnadsprognos på ca 12 månader med behandling, såsom kirurgi, kemo- och strålningsterapi. Tumörerna är heterogena, vilket innebär att celler har flera typer av mutGliomas are neoplasms arising in the central nervous system (CNS), and constitute the most common primary brain tumor. They are classified depending on the grade and morphology, from grade I, pilocytic astrocytoma, to grade IV, glioblastoma multiforme (GBM). Glioblastomas constitute a great challenge in treatment due to their disseminating nature. Classical treatments such as surgery, radiation th

Current understanding of microglial involvement in disease is influenced by the observation that recruited bone marrow (BM)-derived cells contribute to reactive microgliosis in BM-chimeric mice. In contrast, a similar phenomenon has not been reported for BM-chimeric rats. We investigated the recruitment and microglial transformation of BM-derived cells in radiation BM-chimeric mice and rats after

An improved clocking scheme and sharper circuit design and logic selection, which have yielded a five-to-tenfold increased in the speed of standard CMOS ICs, are discussed. The clocking strategy relies on a true single-phase clock, device sizes are varied to optimize their speed, and a precharged logic style reduces capacitive loads. The tradeoff is roughly a doubling of circuit area. The high-spe

Over the past few years, information technology has changed the way we live, work, and communicate with each other. The two outstanding trends of Internet and cellular telephony growth will now enter a new phase when the two technologies converge into 2.5 and 3G networks. The success of cellular telephony is due to the mobility factor, and the success of the Internet is due to its architecture, wh

The main goal of prostate cancer tissue biomarkers is to improve diagnostic and prognostic accuracy. A particularly important question is whether the cancer needs immediate treatment or if treatment can be deferred. It is highly unlikely that a single biomarker that provides comprehensive prognostic information about a newly diagnosed prostate cancer will be forthcoming. Despite extensive research

The aim of this project has been to study timber house manufacturers and provide guidance to those who aim to increase efficiency through the adaption of product modeling and eventually configuration. The findings in this report are based on a series of case studies within the abovementioned industry, which serves as a basis for the analysis and recommendations given. The Swedish timber house man

Recent studies have suggested that regeneration of non-haematopoietic cell lineages can occur through heterotypic cell fusion with haematopoietic cells of the myeloid lineage. Here we show that lymphocytes also form heterotypic-fusion hybrids with cardiomyocytes, skeletal muscle, hepatocytes and Purkinje neurons. However, through lineage fate-mapping we demonstrate that such in vivo fusion of lymp