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Cell reprogramming technologies have enabled the generation of various specific cell types including neurons from readily accessible patient cells, such as skin fibroblasts, providing an intriguing novel cell source for autologous cell transplantation. However, cell transplantation faces several difficult hurdles such as cell production and purification, long-term survival, and functional integrat
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The indoor climate in buildings has changed in the last decade due to more efficient climatic systems, floor heating systems and larger open floor areas with more natural light. All this has induced increasing ranges of relative humidity between different seasons. Also with decreasing relative humidity (in the winter 30-50% RH, in the summer 70-90% RH), floor-heating systems increase the temper
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Colorectal cancer is the third most common type of cancer, and the second leading cause of cancer-related deaths in the Western world. Chronic inflammation, such as inflammatory bowel diseases (IBD), increases the risk of cancer. Cysteinyl leukotrienes are pro-inflammatory mediators that are involved in IBD. They are ligands to the G-protein coupled receptors CysLT1R and CysLT2R, of which CysLT1R
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Nocturnal hypoglycemia is a common and potentially very dangerous condition facing persons with insulin-treated diabetes. To reduce the risk of going low while sleeping, many patient wilfully elevate their glucose level before bedtime, thereby also eroding the conditions for a sound glucose control for the next day. Recent advances in sensor technology allow for real-time frequent monitoring of th
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Background: Integument-related toxicities are common during epidermal growth factor receptor (EGFR)-targeted therapy. Panitumumab is a fully human monoclonal antibody targeting the EGFR that significantly improves progression-free survival when added to chemotherapy in patients with metastatic colorectal cancer who have wild-type (WT) KRAS tumours. Primary efficacy and tolerability results from a
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Sex hormones play a key role in the development of breast cancer. Certain polymorphic variants (SNPs and repeat polymorphisms) in hormone-related genes are associated with sex hormone levels. However, the relationship observed between these genetic variants and breast cancer risk has been inconsistent. We conducted a case-control study nested within two prospective cohorts to assess the relationsh