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The history of TRP channels and bladder started in the 1980-ies with the studies of Maggi and collaborators, who created the basis for using capsaicin and other vanilloids in LUT disorders. This narrative review gives a brief history of bladder TRP channels, from their discovery, distribution, and function in the bladder to the rationale for and current status of the use of agents acting on them i

Control of the material microstructure in terms of the grain size is a key component in tailoring material properties of metals and alloys and in creating functionally graded materials. To exert this control, reliable and efficient modeling and simulation of the recrystallization process whereby the grain size evolves is vital. The present contribution is a review paper, summarizing the current st

The Kuramoto model of coupled phase oscillators is often used to describe synchronization phenomena in nature. Some applications, e.g., quantum synchronization and rigid-body attitude synchronization, involve high-dimensional Kuramoto models where each oscillator lives on the n-sphere or SO(n). These manifolds are special cases of the compact, real Stiefel manifold St(p,n). Using tools from optimi

Here we study the role of negative shifts in public opinion in the economic lives of under-represented racial groups by investigating sudden changes in views towards Asian people following the anti-Chinese rhetoric that emerged with the COVID-19 pandemic, and associated changes in employment status and earnings in the US labour market. Using data from the Current Population Survey, we find that, u

This article discusses the role of affect in the credibility assessment process in queer asylum claims. Through 27 semistructured interviews with caseworkers, it explores how sexual truth, in the Greek asylum apparatus, is affectively produced and analyses how access to asylum is intermediated by affective control of who is considered the “good” sexual citizen. According to the research material,

BACKGROUND: After over a decade of developments in field collection, laboratory methods and advances in high-throughput sequencing, contamination remains a key issue in ancient DNA research. Currently, human and microbial contaminant DNA still impose challenges on cost-effective sequencing and accurate interpretation of ancient DNA data.RESULTS: Here we investigate whether human contaminating DNA

It is shown that the commonly used approximation for the no-loss angle-resolved photocurrent from solids in general violates the optical selection rules if the final-state inverse low-energy electron diffraction orbital is taken to be damped. The violations occur in the velocity formula, which is inconsistent with the corresponding and commonly used acceleration formula in which the matrix element

About 1 in 4 children exposed to a traumatic event will develop symptoms of PTSD, separation anxiety, obsessive-compulsive disorder, specific phobia, generalised avoidance and/or depression that persist more than one month after the trauma, and greatly interfere with individual and family functioning. Trauma-focused cognitive-behavioural therapy (TF-CBT) can reduce these symptoms and greatly impro

In software engineering research, experiments are conducted to evaluate new methods or techniques. The experimentation as such is beginning to mature, but little effort is spent on learning across different studies, except for a few meta-analyses. Meta-analysis can be applied to a set of experiments with the same design. This paper discusses learning across a set of experimental studies on fault d

University start-ups are, in the Organisation for Economic Co-operation and Development (OECD) and European Union (EU) policy setting, viewed as important means to transform scientific advances into innovations, corresponding both to market and societal needs (Mowery & Sampat, 2005; Rider, Hasselberg, & Waluszewski, 2013). The high expectations on the ability to directly transform social a

The European Society of Cardiology (ESC) 2023 guidelines for the management of infective endocarditis (IE) stress that a multidisciplinary approach is needed to manage patients with IE. In our view, the guidelines do not include the relevant perspectives from modern microbiology. The diagnostic criteria for IE were changed in the ESC 2023 guidelines, and many IE-causing pathogens are either not cl