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Alzheimer's disease (AD) is characterized by pathological aggregation of β-amyloid peptides and MAP-Tau protein. β-Amyloid (Aβ) is a peptide responsible for extracellular Alzheimer's plaque formation. Intracellular MAP-Tau aggregates appear as a result of hyperphosphorylation of this cytoskeletal protein. Small, oligomeric forms of Aβ are intermediate products that appear before the amyloid plaque

Time cannot be directly perceived; instead, its flow is inferred from the influx of sensory information. To prevent sensory overload, attentional mechanisms split up information into processable units. This portioning remains imperceptible to the individual. However, the length of these units still influences the speed of perception and the speed at which behaviors are performed. Previous studies

Purpose – In the last decade, greater attention has been paid to the role of management accounting and control (MAC) in making professional organizations more horizontal. The authors argue that earlier research has not shown how the interrelatedness between professional identities and MAC influences attempts to make organizations more horizontal. In this paper the authors respond to the call for m

On the day of the 2016 summer solstice, June 21, MAX IV, the new synchrotron radiation facility in Lund, Sweden, will be inaugurated. MAX IV is setting a new standard in terms of emittance, thereby providing beamlines with the best possible brilliance and coherence. At the same time, MAX IV continues a more than three-decades-long successful history of Swedish synchrotron-radiation-based research.

The emergent nature of the innovation process has always rendered it an elusive subject of study. Nonetheless, academics remained undeterred in their attempts to articulate the innovation process in academics terms as attested by the growing amount of research on the topic. Existing theories for explaining innovation (or the lack of innovation) center on empirical samples from large firms in the h

Many modern software applications have performance requirements, like mobile and embedded systems that must keep up with sensor data, or web services that must return results to users within an acceptable latency bound. For such applications, the goal is not to run as fast as possible, but to meet their performance requirements with minimal resource usage, the key resource in most systems being en

Today, commercially used brasses commonly contain 2 to 4 wt.% lead. As the availability of low-lead and lead-freebrass increase, there are environmental incentives for investigating the consequences of replacing thelead-containing brasses with lead-free equivalents. Generally, lead-free brass is expected to have a lowermachinability than its lead-alloyed counterpart, implying a higher manufacturin

Population-based metaheuristic algorithms are powerful tools in the design of neutron scattering instruments and the use of these types of algorithms for this purpose is becoming more and more commonplace. Today there exists a wide range of algorithms to choose from when designing an instrument and it is not always initially clear which may provide the best performance. Furthermore, due to the nat

Huntington's disease (HD) is an incurable, inherited, progressive neurodegenerative disorder that is defined by a combination of motor, cognitive and psychiatric features. Pre-clinical and clinical studies have demonstrated an important role for the dopamine (DA) system in HD with dopaminergic dysfunction at the level of both DA release and DA receptors. It is, therefore, not surprising that the d

Liabilities of newness and smallness as well as other issues (e.g., “imprinting”) that affect nascent firms represent foundational entrepreneurship issues. The articles in this Special Issue examine if and how these critical issues have changed over time, especially given recent innovations (e.g., crowdfunding) and other trends in society. We believe that a special issue devoted to these topics is