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Autoimmune thrombocytopenic purpura (AITP) is a bleeding disorder in which autoantibodies are directed against an individual's own platelets, leading to enhanced clearance through Fc receptor (R)-mediated phagocytosis by macrophages residing in the reticuloendothelial system, particularly in the spleen. Although the immunopathogenesis of the disease is autoantibody-mediated, there is now substanti

Decarbonizing society will require a shift toward renewable electricity production. However, the temporal configuration of renewables requires that demand adapt accordingly. Introducing intermittent electricity production will thus require end users to be more flexible in their use of electricity. Flexibility capital has been promoted as a concept for analyzing material preconditions in order to u

We report on precise Doppler measurements of L231-32 (TOI-270), a nearby M dwarf (d = 22 pc, M = 0.39 M, R = 0.38 R), which hosts three transiting planets that were recently discovered using data from the Transiting Exoplanet Survey Satellite (TESS). The three planets are 1.2, 2.4, and 2.1 times the size of Earth and have orbital periods of 3.4, 5.7, and 11.4 d. We obtained 29 high-resolution opti

It has been known for decades that risk factors for diabetes and cardiovascular disease (CVD) tend to cluster. Metabolic syndrome refers to this risk factor clustering for some of the more well-established and dangerous risk factors. This chapter provides a historical overview on the concept of the metabolic syndrome; describes the clinical criteria used in the definition of the metabolic syndrome

About 40 years ago, a subpopulation of small neurons in the cerebellar nuclei was shown to project to the inferior olive, the source of the climbing fiber input to the cerebellum. This nucleo-olivary projection follows the zonal and probably also microzonal arrangement of the cerebellum so that closed loops are formed between the neurons in the olive, the cerebellar cortex, and the nuclei. Althoug

Research into and widespread knowledge about the Assyrian Genocide, called Seyfo by Assyrians, is a recent phenomenon. Assyrians themselves have always known of the tragic events that occurred during the First World War, but it took some time before these were conceptualized as genocide and became an important element in the collective memory of the people that demanded recognition. In this articl

Nature contains an endless supply of natural products and has for long been a source of inspiration for the pharmaceutical industry. Many of the drugs currently in clinical use originate from natural products. Paclitaxel, the active substance in the anti cancer medicine Taxol, was first isolated from the Pacific yew tree (Taxus brevifolia) in the early 1960s during a screening program for novel an

In this paper, some fundamental problems concerning the verification of fire safety engineering designs based on performance-based building regulations are discussed. It can be questioned if the approach taken by many practitioners today is sufficient to fulfil the requirements laid out in the building code, i.e. society’s demand for fire safety. Examples of this deficiency are that interdependenc