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The most common pediatric malignancy is acute lymphoblastic leukemia (ALL), of which T-cell ALL (T-ALL) comprises 10–15% of cases. T-ALL arises in the thymus from an immature thymocyte as a consequence of a stepwise accumulation of genetic and epigenetic aberrations. Crucial biological processes, such as differentiation, self-renewal capacity, proliferation, and apoptosis, are targeted and derange
Objectives: This study aimed to investigate the effects of adding adjunct mechanical imaging to mammography breast screening. We hypothesized that mechanical imaging could detect increased local pressure caused by both malignant and benign breast lesions and that a pressure threshold for malignancy could be established. The impact of this on breast screening was investigated with regard to reducti
Muscular dystrophy is a group of genetic disorders that lead to muscle wasting and loss of muscle function. Identifying genetic modifiers that alleviate symptoms or enhance the severity of a primary disease helps to understand mechanisms behind disease pathology and facilitates discovery of molecular targets for therapy. Several muscular dystrophies are caused by genetic defects in the components
A recent rise in climate-related risks, encompassing floods, landslides, storms, and heat waves, has been noted across Sweden, resulting in significant property damage amounting to millions of Euros. While contemporary homes are being developed with climate-resilient designs, the existing housing stock remains exposed to the dynamic challenges of climate hazards. The primary research objective is
Studies within second language learning indicate that higher-order thinking skills (HOTS) are important for the process of learning a new language. At the same time, previous literature indicates that assessment tasks in online courses often focus on lower-order thinking skills. Little is still known about if and how thinking skills are assessed in online EFL courses. Hence, the purpose of this st
Lösningen av de pågående klimat- och energikriserna kräver en radikal omvandling av energisystemet, där hållbarhet, inga koldioxidutsläpp och energieffektivitet bör spela en avgörande roll.Denna revolution bör sträcka sig till alla delar av energisystemet, inklusive sektorn för uppvärmning och kylning av byggnader, som står för en tredjedel av Europas slutliga energibehov och på den europeiska konThe solution of the undergoing climate and energy crises requires a radical transformation of the energy system, in which sustainability, no carbon emissions and energy efficiency ought to play a paramount role. This revolution should extend to all areas of the energy system, including the space heating and cooling sector, which accounts for a third of the European final energy demand and, in the
The book constitutes a basic, concise, yet rigorous first course in complex analysis, for undergraduate students who have studied multivariable calculus and linear algebra. The textbook should be particularly useful for students of joint programmes with mathematics, as well as engineering students seeking rigour. The aim of the book is to cover the bare bones of the subject with minimal prerequisi
The movement of plants, animals, and microorganisms by humans, consciously or unconsciously, has changed both ecosystems and societies throughout history. This article focuses on one such transformative species, lodgepole pine, and its relocation from northwestern America to northern Sweden in the mid-twentieth century. A cultural biography of the lodgepole pine’s existence in Sweden examines how
