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The complexity of the brain, in which different neuronal cell types are interspersed and complexly interconnected, has posed a major obstacle in identifying pathophysiological mechanisms underlying prevalent neurological disorders. This is largely based in the inability of classical experimental approaches to target defined neural populations at sufficient temporal and spatial resolution. As a con
Coronary heart disease (CHD) is an archetypical multifactorial disorder that is influenced by genetic susceptibility as well as both modifiable and nonmodifiable risk factors, and their interactions. Advances during recent years in the field of multifactorial genetics, in particular genomewide association studies (GWASs) and their meta-analyses, have provided the statistical power to identify and
BK virus associated nephropathy occurs in approximately 5% of renal transplant recipients. Quantitation of BKV DNA in serum/plasma early in the course of disease has been suggested to be an important diagnostic tool for polymavirus-associated nephropathy (PVAN). The aim of this study was to develop a BKV real-time PCR (qPCR), which could be included in a diagnostic qPCR platform. Additionally, the
One subproject within the global Chromosome 19 Consortium is to define chromosome 19 gene and protein expression in glioma-derived cancer stem cells (GSCs). Chromosome 19 is notoriously linked to glioma by 1p/19q codeletions, and clinical tests are established to detect that specific aberration. GSCs are tumor-initiating cells and are hypothesized to provide a repository of cells in tumors that ca
Abstract Background: Many people with a visual impairment have only peripheral vision. However, there is limited knowledge of the peripheral optics of the eye and only some measurements are available in this field. Methods: We simulated the paths of peripheral rays through the eye by means of raytracing. Five programs were compared. The OSLO raytracing software proved to be not only the best one
The Cognitive Interview (CI) is a well-researched interview method and the research results show that CI, compared with more conventional interview styles, enhances witnesses’ memory. However, not much research has been done on the question of how CI affects the realism of eyewitnesses’ judgments of confidence in the veracity of their interview statements. In a previous study (Granhag, Jonsson &am
As Rubenson has argued, "the main problem with life long learning is that it fails to critically assess how conditions for individual development, ethnic and social background, previous schooling and working life conditions create very different preconditions for life long learning" (Rubenson, 1996, p. 43). Using longitudinal data from the Malmö Longitudinal Study, the paper clarifies how differen
Nature contains an endless supply of natural products and has for long been a source of inspiration for the pharmaceutical industry. Many of the drugs currently in clinical use originate from natural products. Paclitaxel, the active substance in the anti cancer medicine Taxol, was first isolated from the Pacific yew tree (Taxus brevifolia) in the early 1960s during a screening program for novel an
In this paper we present one approach to understand palpability from the perspective of eco-systems of palpable devices. We will introduce the notion of Palpable Interaction Ecology that particular focus upon the properties that emerge from the interaction between people, their practices and palpable devices. This approach is derived from research into the use of pervasive healthcare services that
