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Autoantibodies are an important marker of human autoimmune diseases and the development of simple, precise and reproducible immunoassays to detect autoantibodies is important to our understanding of human autoimmunity. GAD65 autoantibodies occur frequently in insulin-dependent diabetic patients and is a useful marker for IDDM. A RIA to detect immunoreactive GAD65 has not been described. In the pre

The HLA-DQ β-chain gene shows a close association with susceptibility or resistance to autoimmune insulin-dependent diabetes mellitus (IDDM) and it has been suggested that the amino acid in position 57 may be of pathogenetic importance. To study the expression of the IDDM associated HLA-DQ β-chain alleles, we immunized rabbits with 12 to 13 amino acid long peptides representing HLA-DQw7 and -DQw8

Teachers are both controlling agents and controlled subjects, in any educational system. Educational research has approached this dual role from a variety of practical and theoretical angles, the most notable perhaps being the perspective of teacher autonomy as it is negotiated between, simply speaking, structure and agency. This essay urges to more critically illuminate the relationship between o

Weather influences both the distribution and life-history strategies of birds. Temperature ranks amongst the more important weather parameters in this regard since warming springs in temperate and high latitudes and more frequent heat-waves globally have caused major changes in breeding phenology and negatively affected adult and juvenile survival, respectively. Both long-term and stochastic chang

The 3D printing industry has been recently affected by two events: the fact that open source (OS) business models are getting momentum, and the widespread diffusion of the Maker Movement. We argue that 3D printers can be conceptualised as innovations which embody both technological and symbolic aspects. If innovations of the first type are solely adopted for their technical utility, innovations wh

Boolean satisfiability (SAT) solvers have improved enormously in performance over the last 10-15 years and are today an indispensable tool for solving a wide range of computational problems. However, our understanding of what makes SAT instances hard or easy in practice is still quite limited. A recent line of research in proof complexity has studied theoretical complexity measures such as length,

When treating limited stage classical Hodgkin lymphoma (cHL), balancing treatment efficacy and toxicity is important. Toxicities after extended-field radiotherapy are well documented. Investigators have aimed at reducing toxicity without compromising efficacy, mainly by using combined modality treatment (CMT), i.e. chemotherapy and limited-field radiotherapy. In some clinical trials, radiotherapy

Climate change researchers argue that a residual domain exists beyond the limits of adaptation to prevent deleterious climate change impacts: this has been labeled as “loss and damage.” Over the last 8 years, there has been significant growth in loss and damage scholarship thus making it imperative to take stock of what we know already and directions for future research. We undertook a quantitativ

Research on ontological security in world politics has mushroomed since the early 2000s but seems to have reached an impasse. Ontological security is a conceptual lens for understanding subjectivity that focuses on the management of anxiety in self-constitution. Building especially on Giddens, IR scholars have emphasized how this translates to a need for cognitive consistency and biographical cont

We review the present status of the Standard Model calculation of the anomalous magnetic moment of the muon. This is performed in a perturbative expansion in the fine-structure constant α and is broken down into pure QED, electroweak, and hadronic contributions. The pure QED contribution is by far the largest and has been evaluated up to and including O(α5) with negligible numerical uncertainty. T

A toy-model with SU(2)TC dynamics confined at high scales ΛTC > 100GeV enables to construct Dirac UV completion from the original chiral multiplets predicting a vector-like nature of their weak interactions consistent with electroweak precision tests. In this work, we investigate a potential of the lightest scalar baryon-like (T-baryon) state B0 = UD with mass mB ≥ 1TeV predicted by the simplest t