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Coronary heart disease (CHD) is an archetypical multifactorial disorder that is influenced by genetic susceptibility as well as both modifiable and nonmodifiable risk factors, and their interactions. Advances during recent years in the field of multifactorial genetics, in particular genomewide association studies (GWASs) and their meta-analyses, have provided the statistical power to identify and

The Rostanga-1 core from west-central Scania provides the most complete succession of the Sandbian (Upper Ordovician) through lower Telychian (Silurian, Llandovery) strata of southern Scandinavia. The Hirnantian is identified in the Kallholn Formation by the presence of a Metabolograptus persculptus Biozone fauna. The Akidograptus ascensus, Parakidograptus acuminatus, Cystograptus vesiculosus and

One subproject within the global Chromosome 19 Consortium is to define chromosome 19 gene and protein expression in glioma-derived cancer stem cells (GSCs). Chromosome 19 is notoriously linked to glioma by 1p/19q codeletions, and clinical tests are established to detect that specific aberration. GSCs are tumor-initiating cells and are hypothesized to provide a repository of cells in tumors that ca

This article studies the Kyoto Protocol’s CDM as an example of hybrid governance, involving both public and private actors, and uses the concept of agency to explore the influence of public and private actors in the governance of the CDM over time. Even though public actors formally govern the CDM, the delegation of project implementation and supervision to private companies has created ample oppo

Parkinson's disease (PD) is characterized by progressive loss of dopaminergic (DA) neurons in the substantia nigra. However, studies of post-mortem PD brains have shown that not only DA neurons but also the noradrenergic (NA) neurons in the locus coeruleus degenerate, and that the NA neurodegeneration may be as profound, and also precede degeneration of the midbrain DA neurons. Previous studies in

The development of T-cell leukaemia following the otherwise successful treatment of three patients with X-linked severe combined immune deficiency (X-SCID) in gene-therapy trials using haematopoietic stem cells has led to a re-evaluation of this approach. Using a mouse model for gene therapy of X-SCID, we find that the corrective therapeutic gene IL2RG itself can act as a contributor to the genesi

The number of nanoparticle-based products on the market is expected to increase considerably during the coming decades. For this to happen a solid supply of high-quality nanoparticles is needed. For metal nanoparticles no large-scale manufacturing method exists today but production using spark discharge generation is believed to be one of the most suitable candidates. Spark discharge generation of

We describe a new technique for automatic identification of stationary, linear systems with a single output. This class of models includes all linear, time-invariant, stochastic, difference equations driven by arbitrary inputs and having stationary, normal disturbances with rational spectra.The parameters of the model are estimated by the method of maximum likelihood. A numerical algorithm for sol