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Exceptional preservation of reidite in the Rochechouart impact structure, France: New insights into shock deformation and phase transition of zircon

Reidite, the high-pressure zircon (ZrSiO4) polymorph, is a diagnostic indicator of impact events. Natural records of reidite are, however, scarce, occurring mainly as micrometer-sized lamellae, granules, and dendrites. Here, we present a unique sequence of shocked zircon grains found within a clast from the Chassenon suevitic breccia (shock stage III) from the ˜200 Ma, 20–50 km wide Rochechouart i

Volatile Organic Compounds Emitted by Fungal Associates of Conifer Bark Beetles and their Potential in Bark Beetle Control

Conifer bark beetles attack and kill mature spruce and pine trees, especially during hot and dry conditions. These beetles are closely associated with ophiostomatoid fungi of the Ascomycetes, including the genera Ophiostoma, Grosmannia, and Endoconidiophora, which enhance beetle success by improving nutrition and modifying their substrate, but also have negative impacts on beetles by attracting pr

Exposure to Particle Beta Radiation in Greater Massachusetts and Factors Influencing Its Spatial and Temporal Variability

Particle radioactivity is a property of airborne particles caused by the presence of naturally occurring or anthropogenic radionuclides. Recent studies have found associations between particle radioactivity and adverse health outcomes, including changes in blood pressure and lung function. However, the spatiotemporal distribution of particle radioactivity and factors influencing its variability ha

Trends and antecedents of inequalities in maternal healthcare coverage in four African countries

Using data between 2003 and 2016, this paper assesses the degree and evolution of socio-economic inequalities in maternal health outcomes in four African countries. The study measures the trends of socio-economic inequalities in maternal healthcare and assesses the sources of socio-economic inequalities in maternal health through a decomposition approach. We find cross-country differences in the e

Serum Short-Chain Fatty Acids and Associations With Inflammation in Newly Diagnosed Patients With Multiple Sclerosis and Healthy Controls

Multiple sclerosis (MS) is a chronic immune-mediated disease characterized by demyelination and neuroaxonal damage in the central nervous system. The etiology is complex and is still not fully understood. Accumulating evidence suggests that our gut microbiota and its metabolites influence the MS pathogenesis. Short-chain fatty acids (SCFAs), such as acetate, propionate and butyrate, are metabolite

Computational Inference, Validation, and Analysis of 5’UTR-Leader Sequences of Alleles of Immunoglobulin Heavy Chain Variable Genes

Upstream and downstream sequences of immunoglobulin genes may affect the expression of such genes. However, these sequences are rarely studied or characterized in most studies of immunoglobulin repertoires. Inference from large, rearranged immunoglobulin transcriptome data sets offers an opportunity to define the upstream regions (5’-untranslated regions and leader sequences). We have now establis

Selective Galectin-8N Ligands : The Design and Synthesis of Phthalazinone-d-Galactals

Ligand selectivity among the highly conserved galectins has been an ever-challenging objective. For galectin-8, a protein prevalent in both pathology and tissue distribution, we report phthalazinone-galactals that show excellent selectivity for the galectin-8N-terminal domain. A dissection of structure–activity relationships of the phthalazinone and an extensive molecular dynamics meta-analysis ac