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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by a progressive loss of motor neurons. Neuroinflammation is apparent in affected tissues, including increased T cell infiltration and activation of microglia, particularly in the spinal cord1,2. Autoimmune responses are thought to have a key role in ALS pathology, and it is hypothesized that T cells contribute to the

Background: Pancreatic cancer continues to retain the highest mortality rate among all major organ cancers. New strategies for early detection are being proposed to increase long-term survival. A plethora of molecular markers are discovered yearly, but so far none have demonstrated screening utility. Summary: Promising discovery technologies include affinity-based proteomics and ddPCR. In the vali

BACKGROUND: People with intellectual disabilities (ID) are known to have a higher risk for a wide range of health conditions compared to the general population. However, there is little research comparing a more comprehensive range of diseases and conditions at different ages. Therefore, the aim of this study was to explore the overall age-specific diagnostic pattern among people with ID compared

Estimating and monitoring migratory bird populations involves significant challenges, even in the most well-studied and easily-counted species, and can be further complicated by long-held but unverified assumptions and by shifting distributions in changing flyway conditions. We illustrate these challenges using Bar-tailed Godwits Limosa lapponica on the East Atlantic Flyway. The subspecies L. l. l

Climate change poses significant challenges, demonstrated by climate threats that are becoming increasingly severe and frequent. This creates a higher need for uncertainty communication that considers risk-based decision-making. Global climate research, synthesised by the Intergovernmental Panel on Climate Change (IPCC), is a starting point for regional climate assessments, for which the Swedish M

Surrogatmoderskap är en metod för att bli förälder som är oreglerad både inom svensk och internationell rätt. I praktiken är det dock omöjligt att ge- nomföra ett surrogatarrangemang inom den svenska sjukvården. Däremot kan man som svensk anlita en surrogatmoder utomlands med hjälp av en surroga- tagentur. Sådana förfaranden har länge varit föremål för debatt och flera fall av exploatering av både

This study investigates binomial consumer brand engagement (vs. advertising avoidance) in the social media context. Grounded in social exchange theory, the relationships between personalized advertising, information control, privacy concerns, advertising avoidance, and consumer brand engagement are analyzed by drawing on a survey comprising n = 429 participants. The findings reveal that personaliz

The identification of top quark decays where the top quark has a large momentum transverse to the beam axis, known as top tagging, is a crucial component in many measurements of Standard Model processes and searches for beyond the Standard Model physics at the Large Hadron Collider. Machine learning techniques have improved the performance of top tagging algorithms, but the size of the systematic

We have used the Cerro Tololo Inter-American Observatory telescopes andspectrographs to record emission lines in eta Carinae from 3093 to8956 Å with a gap between 4432 and 5696 Å. A resolving powerof about 20,000 was used throughout. Accurate wavelengths, peakintensities relative to the local continuum, and line identificationsare presented. The data are briefly discussed with respect to the state