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MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of miRNAs are expressed and there is a growing body of evidence demonstrating that miRNAs are essential for brain development and neuronal function. Conditional knockout studies of the core components in the miRNA biogenesis pathway, such as Dicer a

Despite improvements in surgical techniques and adjuvant chemotherapy, the overall mortality rates in pancreatic cancer have generally remained relatively unchanged and the 5-year survival rate is actually below 2%. This paper will address the importance of achieving an early diagnosis and identifying markers for prognosis and response to therapy such as genes, proteins, microRNAs or epigenetic mo

We have established long-term cultures of postnatal retinal cells on arrays of gallium phosphide nanowires of different geometries. Rod and cone photoreceptors, ganglion cells and bipolar cells survived on the substrates for at least 18 days in vitro. Glial cells were also observed, but these did not overgrow the neuronal population. On nanowires, neurons extended numerous long and branched neurit

We have investigated the detuning of the antennas and the ear-to-ear link loss for the in-the-ear (ITE) binaural hearing aids considering the different heterogeneous human phantoms through FDTD simulations. It was found that the resonance frequency shifts differently for different phantoms and between the ears within the same phantom. The ear-to-ear link loss between the antennas for the homogeneo

One way to bring order into the often muddled picture we have of interdisciplinarity is to sort interdisciplinary projects or aims by the kinds of element that interact in encounters between researchers of the two or more disciplines involved. This is not the usual approach. Since the early seventies and the publication of Erich Jantsch (1972), at least, the level of integration of the disciplines

The article surveys the Medieval and Early Modern reception of two ancient Greek myths: the stories about the Phoenician princess Europe and her brother Kadmos. During the 12th - 17th century the interpretation of pagan myths flourished in Europe, justified by allegorical exegesis. The myths of Europe and Kadmos were viewed as disguised teachings containing historical, moral or religious truth. Fo

We have measured critical supersaturations of dried single component particles of sodium caprylate (CH3(CH2)6COONa), sodium caprate (CH3(CH2)8COONa), sodium laurate (CH3(CH2)10COONa) and sodium myristate (CH3(CH2)12COONa), respectively, in the diameter range 33-140 nm at 296 K using a static thermal gradient diffusion cloud condensation nucleus counter. These fatty acid sodium salts are surface ac

The use of public space is an important part of women’s and men’s daily lives in cities and an important arena to promote social inclusion in cities. Public space consists of places for social encounter and exchange, places for political action and participation in public life and plays an important role as places for economic activities. This paper presents a case study of a neighbourhood in San

Results from experiments on laboratory scale fedbatch processes are presented as well as analysis and design of the control system. The main reason for control is to track the drastic growth in feed demand during a cultivation. Variations in the amount and quality of the inocculum makes precalculated dosage schemes of limited value to obtain reproducible cultivation conditions. Two processes have

Chlorophyll biosynthesis is initiated by magnesium chelatase, an enzyme composed of three proteins, which catalyzes the insertion of Mg2+ into protoporphyrin IX to produce Mg-protoporphyrin IX. In barley (Hordeum vulgare L.) the three proteins are encoded by Xantha-f, Xantha-g and Xantha-h. Two of the gene products, XanH and XanG, belong to the structurally conserved family of AAA+ proteins (ATPas