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Synucleinopathies and tauopathies are neurodegenerative disorders characterized by the pathological accumulation of α-synuclein (α-syn) and tau proteins, respectively. These disorders are traditionally managed with symptomatic treatments without addressing the underlying pathologies. Recent advancements in passive immunotherapies, notably the FDA approval of the amyloid-beta (Aβ)-targeting antibod
Pancreatic cancer continues to be a major cause of cancer deaths worldwide. Characterizing the tumors of long-term survivors (≥5 years survival) would create opportunities in prognostic and therapeutic strategies. In this study, RNA sequencing data was used to identify differentially expressed genes (DEGs) in tumors of long-term survivors (LTS) vs short-term survivors (STS). Using LASSO-Cox regres
Sulfonate ester hydrolysis has been the subject of recent debate, with experimental evidence interpreted in terms of both stepwise and concerted mechanisms. In particular, a recent study of the alkaline hydrolysis of a series of benzene arylsulfonates (Babtie et al., Org. Biomol. Chem. 10, 2012, 8095) presented a nonlinear Brønsted plot, which was explained in terms of a change from a stepwise mec
Trots att majoriteten av dem som dör av opioidöverdoser haft kontakt med sjukvård, socialtjänst eller kriminalvård, visar en ny analys att en stor grupp – nästan hälften – saknar betydande vårdkontakter kopplade till sina drogproblem. För att stärka det förebyggande arbetet mot överdoser behövs en förändring i vården, där lågtröskelinsatser kompletteras med bredare screening och mindre stigmatiser
Adult neurogenesis is a dynamic and highly regulated process, and different studies suggest that dopamine modulates ventricular-subventricular zone (V-SVZ) neurogenesis. However, the specific role of dopamine and the mechanisms/factors underlying its effects on physiological and pathological conditions such as Parkinson's disease (PD) are not fully understood. Recent studies have described counter
The building and construction sector is responsible for a significant portion of embodied and energy related carbon emissions. Efforts to reduce this are reflected in the need for improved sustainability in the design, construction, and operation of structures such as buildings and bridges. This issue has become more prominent in recent decades due to the ongoing climate crisis. A historical revie
In this paper we develop two models; the without shortages and the completely backlogging shortages with the price dependant demand rate under time value of money and inflation, finite time horizon and exponentially deterioration rate with the objective of maximizing the present worth of the total system profit. Using the dynamic programming method for each model, we are able to obtain different s
The aim of this study was, by analysing recoveries and resightings of Caspian Terns Hydroprogne caspia ringed in Sweden, (1) to identify areas of importance during their migration and wintering, (2) to investigate the annual routines of migration and wintering of different age categories, and (3) to investigate how human activities, especially shooting, have affected survival of Caspian Terns over
Stroke affects a vast amount of people every year. As a result, many survivors have at least partially lost some of their abilities which are necessary to complete everyday activities. Although rehabilitation can be used to improve those abilities, many survivors claim that conventional methods are demotivating and discouraging. The aim of this project is to develop and test interactive objects, w
