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Finite-strain thermo-viscoplasticity for case-hardening steels over a wide temperature range

The aim of this work is the development of a thermodynamically consistent fully coupled thermo-viscoplastic material model for metals undergoing finite deformations. A multiplicative split of the deformation gradient into a thermal, an elastic and a plastic part is introduced, where isotropic thermal expansion and isochoric plastic deformation are assumed. The model is based on a decomposition of

Internal tandem duplication mutations in the tyrosine kinase domain of FLT3 display a higher oncogenic potential than the activation loop D835Y mutation

Acute myeloid leukemia (AML) remains the most common form of acute leukemia among adults and accounts for a large number of leukemia-related deaths. Mutations in FMS-like tyrosine kinase 3 (FLT3) is one of the most prevalent findings in this heterogeneous disease. The major types of mutations in FLT3 can be categorized as internal tandem duplications (ITD) and point mutations. Recent studies sugge

Late-Holocene vegetation dynamics in response to a changing climate and anthropogenic influences – Insights from stratigraphic records and subfossil trees from southeast Lithuania

To increase our understanding of long-term climate dynamics and its effects on different ecosystems, palaeoclimatic and long-term botanical reconstructions need to be improved, in particular in underutilized geographical regions. In this study, vegetation, (hydro)climate, and land-use changes were documented at two southeast Lithuanian peatland complexes – Čepkeliai and Rieznyčia – for the Late-Ho

A Centre for Teaching and Learning ”Moving in from the Margins”

Background: Faculty development roles are changing within organizations (Gibbs 2013). In previous research the expanding role in organizations as “Coming in from the margins” was described (Schroeder 2011). We studied how different levels of participation evolved within a research intense faculty with a complex organization and various educational programs.Summary of Work: The Centre was establish

Poetic Diction and Poetic References in the Preludes of Plato’s Laws

This doctoral dissertation investigates how Plato elaborates and incorporates the works of the poets in the preludes to the laws. It is argued that the poetic style of the preludes represents a key element for the Athenian’s purpose of persuading the citizens of Magnesia to spontaneously abide to the new legislation that is being laid out.The analysis is divided in four chapters. Chapter 1 discuss

Sustainable agricultural intensification in four Tanzanian villages—a view from the ground and the sky

Agricultural intensification based on smallholders is among many economists viewed as a necessary developmental path to ensure food security and poverty reduction in sub-Saharan Africa. Increasingly, a one-sided focus on raising productivity in cereals has been questioned on environmental grounds, with the concept of sustainable agricultural intensification (SAI) emerging from the natural sciences

Update on the pathophysiology of transfusion-related acute lung injury

PURPOSE OF REVIEW: The aim of this study was to discuss recent advances regarding the pathogenesis of transfusion-related acute lung injury (TRALI), which highlight the pathogenic role of macrophages. RECENT FINDINGS: TRALI remains a leading cause of transfusion-related fatalities, despite the success of the mitigation strategy, and therapeutic approaches are unavailable. Neutrophils (PMNs) are re

GARD : An in vitro platform for toxicological assay development

Life in modern society is intricately intertwined with the results of continuous technological advances. Thishas given rise to daily routines where people are frequently exposed to a wide variety of chemicals.Though many of the chemicals do not generally induce adverse health effects upon normal exposure,several of them has the potential to negatively impact health. Indeed, in order to create prod

Distribution of chrome-spinel grains across the 3He anomaly of the Tortonian Stage at the Monte dei Corvi section, Italy

The present-day ocean-climate system configuration took shape during the Miocene Epoch. Toward the end of the epoch, in the late Tortonian at ca. 8.5 Ma, there was an exceptional event: collisional disruption of an >150-km-diameter asteroid, which created the Veritas family of asteroids in the asteroid belt. This event increased the flux of interplanetary dust particles rich in 3He to Earth and pr

Quantification and detection of genetic risk factors in the familial aggregation of cancer : Habilitation thesis

SummaryCancer is a multifactorial inheritance disorder caused by a combination of small variations in genes, often acting together with environmental factors. GWASs provide a potential method to investigate the genetic basis of such complex diseases, but they are limited to two main classes of cancer susceptibility variants with different levels of risk and prevalence in the general population: ra

APOGEE Data and Spectral Analysis from SDSS Data Release 16 : Seven Years of Observations including First Results from APOGEE-South

The spectral analysis and data products in Data Release 16 (DR16; 2019 December) from the high-resolution near-infrared Apache Point Observatory Galactic Evolution Experiment (APOGEE)-2/Sloan Digital Sky Survey (SDSS)-IV survey are described. Compared to the previous APOGEE data release (DR14; 2017 July), APOGEE DR16 includes about 200,000 new stellar spectra, of which 100,000 are from a new south

Ferrochelatase and Magnesiumchelatase: Metal chelation studied with mutants

Popular Abstract in Swedish Tänk dig en solig sommardag. Du går runt med en glass i handen och mår allmänt bra. Runt om dig finns gröna lummiga träd och vackra blommor i alla möjliga färger. Naturen visar verkligen sin vackraste sida. I dagens samhälle tänker man inte så ofta på den mångfald av färger som omger oss. Den blåa himlen, den gula solen, det röda blodet och det gröna gräset. Kanske bero

A Frozen Colophon in Ps 72?

The colophon in Ps 72:20 has long been puzzling psalm scholars. It reads כלו תפלות דוד בן־ישי—the prayers of David, son of Jesse, are ended—and as such it raises a number of questions. The first observation to be made is that the word תפלה is used, not תהלה. That this is a potential problem is clear already in the LXX, where תפלה is corrected to ὕμνοι. Secondly, the claim that the prayers of David

Lost in Translation: Queer Studies in Sweden

The word queer landed in Sweden in a terminological and theoretical vacuum. It was not that nobody had studied issues and theories relating to sexualities and identities before queer theory were introduced, but the approach of the then new queer theory was slightly different. Above all, it concerned a term that had no history in the Swedish language. Queer is not a Swedish word, and therefore it c

Characterization of Surfaces Relevant to Nanotechnology

In this thesis investigations of the structure and dynamics of semiconductor surfaces relevant for the synthesis of nanostructures are presented. The studies were performed using Scanning Tunneling Microscopy (STM), Low Energy Electron Diffraction (LEED), and Spectroscopic PhotoEmission and Low Energy Electron Microcopy (SPELEEM). Nanostructures are defined as objects with one or more dimensions o