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Cancer results from a sequence of genetic and epigenetic changes that lead to a variety of abnormal phenotypes including increased proliferation and survival of somatic cells and thus to a selective advantage of precancerous cells. The notion of cancer progression as an evolutionary process has been attracting increasing interest in recent years. A great deal of effort has been made to better unde
Introduction: Ankle fractures are commonly treated by open reduction and internal fixation with plate and screws. Unplanned return to theatre is common, in many cases to extract prominent osteosynthesis material from the lateral malleolus as swelling subsides. We hypothesised that patients operated with a posterolateral plate placement on the lateral malleolus would have fewer reoperations, and fe
Purpose: The development of blood biomarkers that reflect Alzheimer’s disease (AD) pathophysiology (phosphorylated tau and amyloid-β) has offered potential as scalable tests for dementia differential diagnosis and early detection. In 2019, the Geneva AD Biomarker Roadmap Initiative included blood biomarkers in the systematic validation of AD biomarkers. Methods: A panel of experts convened in Nove
Noble metal-based catalysts have numerous industrial uses, and maximum utilization of the precious metals by lowering the metal loading is of significant interest in heterogeneous catalysis research. However, lowering the metal loading could lead to single-atom metal species formation, which may not be active for important reactions like propylene oxidation. We report a way to drastically reduce p
The distinction between primary and secondary iconic signs, which I first made with regard to pictures, has been applied by other scholars to language, gesture, and music. Taking stock of this process, it has become necessary to clarify the distinction, insisting on the fact that secondary iconicity is not conventionality, but a kind of iconicity which is in itself not sufficient to define a meani
COVID-19 has turned our lives upside down. The first lockdown occurred in Italy in the spring of 2020, drastically disrupting people’s daily schedules, work schedules, socialisation, and relationships with co-workers, family and friends. To overcome physical isolation, collect impressions and keep a record of the period, the “How are you?” online questionnaire has been designed as a potential conv
Memristors implemented as resistive random-access memories (RRAMs) owing to their low power consumption, scalability, and speed are promising candidates for in-memory computing and neuromorphic applications. Moreover, a vertical 3D implementation of RRAMs enables high-density crossbar arrays at a minimal footprint. Co-integrated III–V vertical gate-all-around MOSFET selectors in a one-transistor-o
The Swedish electric vehicle fleet is rapidly growing, creating a need to include their charging demand in future grid planning. Charging stations are often placed based on the needs of the transport system, and the grid connection is considered at a later stage with long lead times. This study proposes selecting charging locations based on grid capacity. Doing this by probabilistic load flow requ
Induced polarization (IP) is a common method in ore exploration. IP spectra measured over a wide frequency range can be used to characterize material properties of ores, slags and other residual material from mines and processing facilities. Previous studies have shown that IP parameters are sensitive to type, content or grain size of electronically conductive or semi-conductive minerals. Up to no
National greenhouse gas inventories (GHGIs) are submitted annually to the United Nations Framework Convention on Climate Change (UNFCCC). They are estimated in compliance with Intergovernmental Panel on Climate Change (IPCC) methodological guidance using activity data, emission factors and facility-level measurements. For some sources, the outputs from these calculations are very uncertain. Invers
