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Background: Exendin-4 is a peptide agonist of the glucagon-like peptide-1 (GLP-1) receptor, currently in clinical trials as a potential disease-modifying therapy for Parkinson's disease. In light of this, it is important to understand potential modes of action of exendin-4 in the brain. Exendin-4 is neuroprotective and has been proposed to be directly anti-inflammatory, and that this is one way it

The exposure to isocyanates is more of an occupational problem than a consumer problem. The main route of exposure is assumed to be through inhalation. Isocyanates that have high vapor pressure, such as TDI, can be airborne at room temperature. Other isocyanates such as MDI are volatile only when heated. Industrial processes that can cause exposure to isocyanates are, for example, spraying or heat

Xylosides are a group of compounds that can induce glycosaminoglycan (GAG) chain synthesis independently of a proteoglycan core protein. We have previously shown that the xyloside 2-(6-hydroxynaphthyl)β-D-xylopyranoside has a tumor-selective growth inhibitory effect both in vitro and in vivo, and that the effect in vitro was correlated to a reduction in histone H3 acetylation. In addition, GAG cha

PURPOSE OF REVIEW: Endoscopic diagnosis of biliary disease is challenging due to difficulties in access, visualization, and sampling. Recent advances in endoscopic technology, ancillary diagnostic methods, and our understanding of autoimmune pancreatitis (AIP) and IgG4-related cholangitis (IRC) have led to improvements in the endoscopic diagnosis of pancreaticobiliary disease. RECENT FINDINGS: S

The increasing presence and activities of people in both urban environments and non-urban areas result in the exposure of many wild animal populations to persistent human disturbance. As a response, individuals in disturbed populations often become tolerant towards humans, which can have significant ecological and societal consequences, for example by affecting ecosystem services and human–wildlif

The Journal of Clinical Investigation R E S E A R C H A R T I C L E 1jci.org Introduction Our capacity to perform well-coordinated movements depends on the activity of 2 pathways linking the striatum with deep basal ganglia nuclei. The direct pathway originates from striatal neurons project- ing monosynaptically to the output nuclei of the basal ganglia (i.e., the globus pallidus pars interna and

https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/jci90132.pdf - 2026-05-30

Over four decades, Indigenous Sámi individuals and communities have submitted to United Nations human rights treaty bodies, including the Human Rights Committee, several complaints in respect of the three Nordic countries Finland, Norway, and Sweden. Many of these Sámi rights cases have made important contributions to the understanding and application of Indigenous peoples’ rights globally, in add

Scholars have characterized Cambodia as a weak state, strong party governance system in which administrative institutions are subordinated to the ruling Cambodian People’s Party (CPP). This article argues that since 2013 Cambodian governance has taken a significant technocratic turn, as party rule has become increasingly dependent on a stronger and more capable administrative state. It traces a re

Abstract Author: Ylva Nilsson Title: A study of a psychosis unit within open psychiatric care from a holistic-view perspective. Supervisor: Frans Oddner Assessor: Anna Angelin The purpose of this study is to examine a new method of working with patients with a mental disability according to a holistic-view perspective. The aim is to find out how the employees at one psychosis unit at a Swedish h

The origin of cometary volatiles remains a major open question in planetary science. Comets may have either agglomerated from crystalline ices condensed in the protosolar nebula (PSN) or from amorphous ice originating from the molecular cloud and interstellar medium. Here, based on the recent argon, krypton, and xenon measurements performed by the ROSINA mass spectrometer on board the European Spa