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In vitro generation of antibodies often requires variable domain sequence evolution to adapt the protein in terms of affinity, specificity, or developability. Such antibodies, including those that are of interest for clinical development, may have their origins in a diversity of immunoglobulin germline genes. Others and we have previously shown that antibodies of different origins tend to evolve a

The ontogeny of the pelturine olenid trilobite Leptoplastides salteri (Callaway, 1877) from the Shineton Shales, Shropshire, England, was first described in 1925 by Frank Raw. Since that time, scanning electron microscopy and other new technologies have revealed many more details of structure, of early developmental stages in particular, than were available to Raw. Whereas protaspides are not pres

Physiological arousal is considered a key factor of gambling behavior. Hence, to understand gambling behavior it is important to study the arousal responses during gambling. Moreover, crucial mechanisms of action could be uncovered by detailing the situations that produce an arousal response. A gamble, or bet, can be partitioned into three distinct phases: (a) decision phase, during which the info

Efficient unit propagation for clausal constraints is a core building block of conflict-driven clause learning (CDCL) Boolean satisfiability (SAT) and lazy clause generation constraint programming (CP) solvers. Conflict-driven pseudo-Boolean (PB) solvers extend the CDCL paradigm from clausal constraints to integer linear constraints, also known as (linear) PB constraints. For PB solvers, many diff

Background: User involvement of people outside academia in research is argued to increase relevance of research for society and to empower the involved lay persons. Frail older people can be a hard to reach group for research and thus an underrepresented group in research. There is a lack of knowledge how collaboration with frail older people should be best performed. Therefore, the aim of this st

This paper explores the translation and implementation of Smart Specialisation in Wales. It finds that rather than taking a new approach to innovation policy, Welsh policy-makers are following a largely cluster-based rationale, which omits the important entrepreneurial discovery process to identify the real strengths of the region. The fresh idea presented by this paper is that a replication of pa

This new book examines the relationship between culture and respect for human rights. It departs from the oft-made assumption that culture is closely linked to ideas about community. Instead, it reveals culture as a quality possessed by the individual with a serious impact on her ability to enjoy the rights and freedoms as recognised in international human rights law in meaningful and effective wa

Knowing the extent to which the acoustic structure of songs is temporally stable is essential to understanding how cultural evolution affects song dialects in oscines. The acoustic structure of the most prevalent variant of the flight-whistle song recorded from male Brown-headed Cowbirds (Molothrus ater) in the Mammoth dialect (Mammoth Lakes, California) from 2005 to 2009 differed significantly an

Petrographic analysis of eight CM carbonaceous chondrites (EET 96029, LAP 031166, LON 94101, MET 01072, Murchison, Murray, SCO 06043, QUE 93005) by electron imaging and diffraction, and X-ray computed tomography, reveals that six of them have a petrofabric defined by shock flattened chondrules. With the exception of Murchison, those CMs that have a strong petrofabric also contain open or mineraliz

The exposure to isocyanates is more of an occupational problem than a consumer problem. The main route of exposure is assumed to be through inhalation. Isocyanates that have high vapor pressure, such as TDI, can be airborne at room temperature. Other isocyanates such as MDI are volatile only when heated. Industrial processes that can cause exposure to isocyanates are, for example, spraying or heat

The increased urbanization and human population growth of the recent decades have resulted in the loss of urban green spaces. One policy used to prevent the loss of urban green space is ecological compensation. Ecological compensation is the final step in the mitigation hierarchy; compensation measures should thus be a last resort after all opportunities to implement the earlier steps of the hiera

DYNAC [1] is a multi-particle beamline simulation code suitable for modelling of the motion of protons, heavy ions, or electrons, moving through linear accelerators and beam transport lines. In this paper, we document extensions written in Python. It will be shown how these Python extensions add a considerable amount of flexibility to DYNAC, while maintaining the calculation speeds available from