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Melatonin is a powerful antioxidant and a synchronizer of many physiological processes. Alteration in melatonin signaling has been reported in a broad range of diseases, but little is known about the genetic variability of this pathway in humans. Here, we sequenced all the genes of the melatonin pathway -AA-NAT, ASMT, MTNR1A, MTNR1B and GPR50 - in 321 individuals from Sweden including 101 patients
The capability of the antibody (Ab) repertoire to mount a response to appropriate epitopes on infectious agents will strongly affect the ability of the immune system to provide protection against disease. Certain epitopes may be poor inducers of immunity but are nevertheless able to promote biologically important protection when recognized by the immune repertoire. We have investigated the recogni
Determination of the glomerular filtration rate (GFR) is generally considered as the most important parameter of quantifying renal function. The GFR is determined as renal or plasma clearance of an ideal filtration marker which is freely filtered by the kidney, does not undergo metabolism, tubular secretion or absorption. Markers that fulfil these demands are inulin, 51Cr-EDTA, 99mTc-DTPA, labelle
Not all people with severe mental illness who attend Individual Placement and Support (IPS) gain and keep their jobs or work full time. Research has indicated a relationship between social disabilities and work performance in this group, and that support provided is often directed towards the social work environment. However, relationships between social skills performed in an authentic work setti
Popular Abstract in Swedish Med snabbare och pålitligare analysresultat finns stora möjligheter till ett ökat utnyttjande av avfallsresurser för produktion av förnybar energi. Resultat från min forskning gör det möjligt att analysera råvaror för biogasproduktion med större säkerhet och med möjligheten att få upp till nio gånger snabbare resultat. Produktion av biogas har under den senaste tiden öA sustainable treatment of organic wastes, generation of renewable energy, reduction of green house gas emissions, limiting the eutrophication and closing the nutrient cycles are several environmental challenges for which anaerobic digestion may be a suitable solution. There is today a large amount of available organic waste materials that could serve as potential feedstock for biogas production.
Sustainable lifestyles and consumption refer to multiple spheres of human activities such as mobility, housing, food and leisure. Increasingly consumers are called upon to assume greater responsibility for changing their lifestyles, primarily through making environmentally sound purchasing choices and changing behavior. To motivate consumers, governments have often focused on improving the provisi
Implementation of open source development practices within commercial settings can bring benefits such as improved source code quality, lower maintenance costs, and increased innovation. However, a widespread in-house implementation of the practices has not been observed. The goal of this research is to understand factors which hinder the implementation. For the purpose, development practices of a
I denna rapport analyseras effekterna av sänkta parkeringsnormer för bostäder för invånarna i det centrumnära, och relativt nybyggda, bostadsområdet Porslinsfabriken i Göteborg. Porslinsfabriken är med en relativt låg parkeringsnorm på 0,57 platser per lägenhet ett bra exempel på en parkeringspolitik som förs i alltfler kommuner. Resultatet visar att 19 procent av hushållen har minskat bilinnehaveThis report analyses the effects of lowered parking requirements for residents in the centrally located, relatively newly built housing area, Porslinsfabriken in Gothenburg. Porslinsfabriken has a relatively low parking requirement of 0.57 places per apartment and is a good example of a parking policy being introduced in many Swedish municipalities. The results show that 19 percent of households h
Popular Abstract in Swedish Fett som tas in i kroppen bryts huvudsakligen ned i tunntarmen med hjälp av ett enzym, lipas och dess regler-protein colipas. Colipas binder sig till lipas och gör att lipas fastnar på fett dropparna som emulgerats av gallsalter. Både lipas och colipas utsöndras av bukspottkörteln. I de gröna växternas blad finns kloroplaster som fångar upp ljus och därvid bildar syre oObesity is a major health problem in the world that increases the occurrence of type-2 diabetes and cardiovascular disease. The reason for obesity is a dysfunction in the regulation of energy balance. It has been shown that dietary fat induces satiety as long as this nutrient stays in the intestine. One important gastrointestinal satiety signal is cholecystokinin (CCK), released from the intestine
In the near future several astronomical observatories in Chile areplanning to use sodium laser guide stars to increase the sky coverageprovided by their adaptive optics facilities. Knowledge of themesospheric sodium layer behavior is crucial to predict the performanceof future laser guide star adaptive optics systems. Whereas the sodiumlayer has been observed quite extensively at several locations
“The laser-induced incandescence (LII) signal is proportional to soot volume fraction” is an often used statement in scientific papers, and it has – within experimental uncertainties – been validated in comparisons with other diagnostic techniques in several investigations. In 1984 it was shown theoretically in a paper by Melton that there is a deviation from this statement in that the presence of
