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The adapter protein APS has previously been shown to be involved in recruiting the ubiquitin E3 ligase c-Cbl to the insulin receptor, the platelet-derived growth factor b-receptor and the erythropoietin receptor, leading to increased degradation of the receptors and inhibition of mitogenesis. Here we demonstrate, by use of immobilized synthetic phosphopeptides corresponding to various autophosphor

Popular Abstract in Swedish Östeuropeisk industri är ökänd både för sin miljöpåverkan och för sin besvärliga ekonomiska sits. Detta gör att resurserna som finns tillgängliga för miljöarbete är små - om dom finns överhuvudtaget. Den möjlighet som då återstår ligger i den förebyggande miljöskyddsstrategin där förbättringarna uppnås genom att gå in i produktionsprocesserna och effektivisera användnin

The passerine major histocompatibility complex (MHC) class I and IIB genes are different from those of the avian model species the chicken because passerines have (1) a larger number of MHC genes, (2) MHC genes with longer introns, and (3) MHC genes that are pseudo-genes. Most passerine MHC genes are transcribed (coding), extremely variable and subject to balancing selection. The high genetic dive

We provide evidence that centromere-specific 155 bp DNA repeats terminate one pair of telomeres at the telocentric, left end of the short fourth chromosome in Chironomus pallidivittatus. Earlier evidence indicated that all other telomeres are terminated by 340 bp telomere-specific repeats. DNA that borders the 155 bp repeat contains a transcriptionally active 396 codon open reading frame (ORF) a f

Linear-transmitters based on combined analog locked loop universal modulator (CALLUM) architectures are attractive, as they promise both high efficiency and high linearity. To date, it has not been possible to analyze a CALLUM transmitter as a linear feedback network due to the nonlinear nature of the control equations governing it. The main purpose of this paper has been the derivation of a linea

The MAX IV facility presently under construction will include two storage rings for the production of synchrotron radiation. The 3 GeV ring will house insertion devices for the production of x-rays while the 1.5 GeV ring will serve UV and IR users. Both rings will be operated at a constant 500 mA of stored current with top-up shots supplied by the 3.5 GeV MAX IV linac acting as a full-energy injec

This report focuses on the use of egress models to assess the optimal strategy in the case of total evacuation in high-rise buildings. A model case study made of two identical twin towers linked with two sky-bridges at different heights has been simulated. The towers are 50 floor high-rise buildings including both vertical and horizontal egress components, namely stairs, occupant evacuation elevat

Since software development is of a dynamic nature, the impact analysis is an inevitable work task. Traceability is known as one factor that supports this task, and several researchers have proposed traceability recovery tools to propose trace links in an existing system. However, these semi-automatic tools have not yet proven useful in industrial applications. Based on an established automation mo

Popular Abstract in Swedish Amerikanska krigare i Vietnam: Krigarvärderingar och myten om krigserfarenheten under Vietnamkriget, 1965-1973.

X-ray free-electron lasers (XFELs) open a new era of X-ray based research by generating extremely intense X-ray flashes. To further improve the spectrum brightness, a self-seeding FEL scheme has been developed and demonstrated experimentally. As the next step, new-generation FELs with high repetition rates are being designed, built and commissioned around the world. A high repetition rate would si